Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049203756> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2049203756 endingPage "51" @default.
- W2049203756 startingPage "45" @default.
- W2049203756 abstract "The purpose of the present study was to determine the possible role of cholinergic mechanisms in the anticonflict effects of the anxiolytic diazepam. Male Sprague-Dawley rats were tested with a modified Geller-Seifter procedure using a multiple reinforcement schedule in which unpunished responding in one component was reinforced according to a fixed-interval 60-sec schedule, and punished responding in the other component resulted in both food and a brief electric shock presentation according to a fixed-ratio 1 schedule. In Experiment 1 (−)-nicotine antagonized the increase in punished responding that was produced by diazepam. In Experiment 2 diazepam produced selective increases in punished responding that again was antagonized by (−)-nicotine, a nicotinic cholinergic agonist, whereas arecoline, a muscarinic cholinergic agonist, did not antagonize diazepam's increase in punished responding. Neither drug produced any significant changes in unpunished responding. In Experiment 3 it was shown that the centrally acting nicotinic antagonist, mecamylamine, was able to block nicotine's antagonism of diazepam. These results suggest that there is an interaction between central nicotinic cholinergic mechanisms and diazepam's anticonflict effects in this animal model for anxiolytics, and support clinical observations that smoking can reduce some effects of benzodiazepines. © 1994 Wiley-Liss, Inc." @default.
- W2049203756 created "2016-06-24" @default.
- W2049203756 creator A5012488000 @default.
- W2049203756 creator A5067058663 @default.
- W2049203756 creator A5073492320 @default.
- W2049203756 date "1994-01-01" @default.
- W2049203756 modified "2023-09-23" @default.
- W2049203756 title "Antagonism of diazepam's anticonflict effects in rats by nicotine, but not by arecoline" @default.
- W2049203756 cites W1976983559 @default.
- W2049203756 cites W1983805202 @default.
- W2049203756 cites W1984930956 @default.
- W2049203756 cites W1989314580 @default.
- W2049203756 cites W1990822844 @default.
- W2049203756 cites W1992592001 @default.
- W2049203756 cites W2021751500 @default.
- W2049203756 cites W2023278723 @default.
- W2049203756 cites W2024886220 @default.
- W2049203756 cites W2028802103 @default.
- W2049203756 cites W2030804523 @default.
- W2049203756 cites W2048763714 @default.
- W2049203756 cites W2070971788 @default.
- W2049203756 cites W2084436311 @default.
- W2049203756 cites W2094815197 @default.
- W2049203756 cites W3024199366 @default.
- W2049203756 cites W6815835 @default.
- W2049203756 doi "https://doi.org/10.1002/ddr.430310108" @default.
- W2049203756 hasPublicationYear "1994" @default.
- W2049203756 type Work @default.
- W2049203756 sameAs 2049203756 @default.
- W2049203756 citedByCount "1" @default.
- W2049203756 countsByYear W20492037562014 @default.
- W2049203756 crossrefType "journal-article" @default.
- W2049203756 hasAuthorship W2049203756A5012488000 @default.
- W2049203756 hasAuthorship W2049203756A5067058663 @default.
- W2049203756 hasAuthorship W2049203756A5073492320 @default.
- W2049203756 hasConcept C126322002 @default.
- W2049203756 hasConcept C134018914 @default.
- W2049203756 hasConcept C15744967 @default.
- W2049203756 hasConcept C170493617 @default.
- W2049203756 hasConcept C185592680 @default.
- W2049203756 hasConcept C188987157 @default.
- W2049203756 hasConcept C22885893 @default.
- W2049203756 hasConcept C2776175493 @default.
- W2049203756 hasConcept C2776880047 @default.
- W2049203756 hasConcept C2777383412 @default.
- W2049203756 hasConcept C2778938600 @default.
- W2049203756 hasConcept C2779547902 @default.
- W2049203756 hasConcept C2781277053 @default.
- W2049203756 hasConcept C33789571 @default.
- W2049203756 hasConcept C71924100 @default.
- W2049203756 hasConcept C98274493 @default.
- W2049203756 hasConceptScore W2049203756C126322002 @default.
- W2049203756 hasConceptScore W2049203756C134018914 @default.
- W2049203756 hasConceptScore W2049203756C15744967 @default.
- W2049203756 hasConceptScore W2049203756C170493617 @default.
- W2049203756 hasConceptScore W2049203756C185592680 @default.
- W2049203756 hasConceptScore W2049203756C188987157 @default.
- W2049203756 hasConceptScore W2049203756C22885893 @default.
- W2049203756 hasConceptScore W2049203756C2776175493 @default.
- W2049203756 hasConceptScore W2049203756C2776880047 @default.
- W2049203756 hasConceptScore W2049203756C2777383412 @default.
- W2049203756 hasConceptScore W2049203756C2778938600 @default.
- W2049203756 hasConceptScore W2049203756C2779547902 @default.
- W2049203756 hasConceptScore W2049203756C2781277053 @default.
- W2049203756 hasConceptScore W2049203756C33789571 @default.
- W2049203756 hasConceptScore W2049203756C71924100 @default.
- W2049203756 hasConceptScore W2049203756C98274493 @default.
- W2049203756 hasIssue "1" @default.
- W2049203756 hasLocation W20492037561 @default.
- W2049203756 hasOpenAccess W2049203756 @default.
- W2049203756 hasPrimaryLocation W20492037561 @default.
- W2049203756 hasRelatedWork W1914592228 @default.
- W2049203756 hasRelatedWork W1968601021 @default.
- W2049203756 hasRelatedWork W1972889490 @default.
- W2049203756 hasRelatedWork W2052463605 @default.
- W2049203756 hasRelatedWork W2092804864 @default.
- W2049203756 hasRelatedWork W2101590601 @default.
- W2049203756 hasRelatedWork W2160817800 @default.
- W2049203756 hasRelatedWork W2257097432 @default.
- W2049203756 hasRelatedWork W2377877839 @default.
- W2049203756 hasRelatedWork W2793006458 @default.
- W2049203756 hasVolume "31" @default.
- W2049203756 isParatext "false" @default.
- W2049203756 isRetracted "false" @default.
- W2049203756 magId "2049203756" @default.
- W2049203756 workType "article" @default.