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- W2049204034 abstract "Alpha-fetoprotein (AFP) is a well-known tumor marker related to hepatocellular carcinoma (HCC). The purpose of this study was to develop a high-sensitivity and low-cost AFP immunosensor for the early diagnosis of cancers by using quartz crystal microbalance (QCM) and self-assembly monolayer (SAM) technologies. The results indicated a high mass-sensitivity (0.299 Hz ml ng−1) and sensing linearity (99.23%) in a range of 10–40 ng/ml AFP concentration measured by the QCM-based AFP immunosensor. No interference effects were observed in bovine serum albumin (BSA) which demonstrated the high binding specificity of the sensor. The result also showed a high degree of correlation (R2 = 0.996) compared with ELISA method. It shows the proposed QCM-based immunosensor is promising for clinical application of AFP determination." @default.
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- W2049204034 date "2013-05-01" @default.
- W2049204034 modified "2023-09-23" @default.
- W2049204034 title "DEVELOPMENT OF QUARTZ CRYSTAL MICROBALANCE-BASED IMMUNOSENSOR FOR DETECTING ALPHA-FETOPROTEIN" @default.
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- W2049204034 doi "https://doi.org/10.1080/10739149.2012.729243" @default.
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