Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049204549> ?p ?o ?g. }
- W2049204549 endingPage "677" @default.
- W2049204549 startingPage "669" @default.
- W2049204549 abstract "Clonal selection theory proposed that individual T cells are specific for a single peptide-MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast array of potential foreign peptide-MHC complexes, and a comprehensive system requires each T cell to recognize numerous peptides and thus be cross-reactive. This compromise on specificity has profound implications because the chance of any natural peptide-MHC ligand being an optimal fit for its cognate TCR is small, as there will almost always be more-potent agonists. Furthermore, any TCR raised against a specific peptide-MHC complex in vivo can only be the best available solution from the naive T cell pool and is unlikely to be the best possible solution from the substantially greater number of TCRs that could theoretically be produced. This 'systems view' of TCR recognition provides a plausible cause for autoimmune disease and substantial scope for multiple therapeutic interventions." @default.
- W2049204549 created "2016-06-24" @default.
- W2049204549 creator A5008376558 @default.
- W2049204549 date "2012-08-24" @default.
- W2049204549 modified "2023-10-15" @default.
- W2049204549 title "Why must T cells be cross-reactive?" @default.
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