Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049205577> ?p ?o ?g. }
- W2049205577 endingPage "126" @default.
- W2049205577 startingPage "109" @default.
- W2049205577 abstract "Reactive oxygen-derived species such as free radicals are formed in living cells by normal metabolism and exogenous sources, and cause a variety of types of DNA damage such as base and sugar damage, strand breaks and DNA-protein cross-links. Living organisms possess repair systems that repair DNA damage. Oxidative DNA damage caused by free radicals and other oxidizing agents is mainly repaired by base-excision repair (BER), which involves DNA glycosylases in the first step of the repair process. These enzymes remove modified bases from DNA by hydrolyzing the glycosidic bond between the modified base and the sugar moiety, generating an apurinic/apyrimidinic (AP) site. Some also possess AP lyase activity that subsequently cleaves DNA at AP sites. Many DNA glycosylases have been discovered and isolated, and their reaction mechanisms and substrate specificities have been elucidated. Most of the known products of oxidative damage to DNA are substrates of DNA glycosylases with broad or narrow substrate specificities. Some possess cross-activity and remove both pyrimidine- and purine-derived lesions. Overlapping activities between enzymes also exist. Studies of substrate specificities have been performed using either oligodeoxynucleotides with a single modified base embedded at a specific position or damaged DNA substrates containing a multiplicity of pyrimidine- and purine-derived lesions. This paper reviews the substrate specificities and excision kinetics of DNA glycosylases that have been investigated with the use of gas chromatography/mass spectrometry and DNA substrates with multiple lesions." @default.
- W2049205577 created "2016-06-24" @default.
- W2049205577 creator A5012088953 @default.
- W2049205577 date "2003-10-29" @default.
- W2049205577 modified "2023-10-15" @default.
- W2049205577 title "Substrate specificities and excision kinetics of DNA glycosylases involved in base-excision repair of oxidative DNA damage" @default.
- W2049205577 cites W108379432 @default.
- W2049205577 cites W134870157 @default.
- W2049205577 cites W1489408430 @default.
- W2049205577 cites W1494022099 @default.
- W2049205577 cites W1499918639 @default.
- W2049205577 cites W1510358641 @default.
- W2049205577 cites W1520315220 @default.
- W2049205577 cites W1526430915 @default.
- W2049205577 cites W1528920733 @default.
- W2049205577 cites W1593685083 @default.
- W2049205577 cites W159888840 @default.
- W2049205577 cites W1599053981 @default.
- W2049205577 cites W1602232100 @default.
- W2049205577 cites W1605551606 @default.
- W2049205577 cites W1682559547 @default.
- W2049205577 cites W1778709156 @default.
- W2049205577 cites W1833739857 @default.
- W2049205577 cites W1845321470 @default.
- W2049205577 cites W1890612916 @default.
- W2049205577 cites W1953968639 @default.
- W2049205577 cites W1965158726 @default.
- W2049205577 cites W1965749713 @default.
- W2049205577 cites W1965790988 @default.
- W2049205577 cites W1966064937 @default.
- W2049205577 cites W1966318682 @default.
- W2049205577 cites W1969190950 @default.
- W2049205577 cites W1972310311 @default.
- W2049205577 cites W1975589890 @default.
- W2049205577 cites W1979336226 @default.
- W2049205577 cites W1981912201 @default.
- W2049205577 cites W1987882604 @default.
- W2049205577 cites W1988230291 @default.
- W2049205577 cites W1991903547 @default.
- W2049205577 cites W1992584287 @default.
- W2049205577 cites W1993514197 @default.
- W2049205577 cites W1994445850 @default.
- W2049205577 cites W1995907499 @default.
- W2049205577 cites W1996258759 @default.
- W2049205577 cites W1997476198 @default.
- W2049205577 cites W1997778801 @default.
- W2049205577 cites W1998426722 @default.
- W2049205577 cites W1998506335 @default.
- W2049205577 cites W2006377201 @default.
- W2049205577 cites W2009032093 @default.
- W2049205577 cites W2010094123 @default.
- W2049205577 cites W2011208405 @default.
- W2049205577 cites W2012291005 @default.
- W2049205577 cites W2012719479 @default.
- W2049205577 cites W2015685676 @default.
- W2049205577 cites W2016803847 @default.
- W2049205577 cites W2017626786 @default.
- W2049205577 cites W2018183276 @default.
- W2049205577 cites W2023256344 @default.
- W2049205577 cites W2025346491 @default.
- W2049205577 cites W2025373592 @default.
- W2049205577 cites W2026960893 @default.
- W2049205577 cites W2029687074 @default.
- W2049205577 cites W2030327204 @default.
- W2049205577 cites W2030666445 @default.
- W2049205577 cites W2031005040 @default.
- W2049205577 cites W2034129646 @default.
- W2049205577 cites W2036103078 @default.
- W2049205577 cites W2037320922 @default.
- W2049205577 cites W2038315213 @default.
- W2049205577 cites W2040911570 @default.
- W2049205577 cites W2041683774 @default.
- W2049205577 cites W2042907868 @default.
- W2049205577 cites W2042937673 @default.
- W2049205577 cites W2043004390 @default.
- W2049205577 cites W2043225353 @default.
- W2049205577 cites W2043299563 @default.
- W2049205577 cites W2044199817 @default.
- W2049205577 cites W2045253685 @default.
- W2049205577 cites W2052724683 @default.
- W2049205577 cites W2061270600 @default.
- W2049205577 cites W2062646486 @default.
- W2049205577 cites W2063703639 @default.
- W2049205577 cites W2064477710 @default.
- W2049205577 cites W2064573253 @default.
- W2049205577 cites W2068407072 @default.
- W2049205577 cites W2073393451 @default.
- W2049205577 cites W2074057782 @default.
- W2049205577 cites W2080392363 @default.
- W2049205577 cites W2080733065 @default.
- W2049205577 cites W2082314990 @default.
- W2049205577 cites W2082520637 @default.
- W2049205577 cites W2083358358 @default.
- W2049205577 cites W2083856509 @default.
- W2049205577 cites W2084505555 @default.
- W2049205577 cites W2089486427 @default.
- W2049205577 cites W2092770418 @default.
- W2049205577 cites W2096136751 @default.