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• W2049205984 abstract "Charles Sawyers and colleagues report that mice expressing a TMPRSS2-ERG fusion develop prostatic intraepithelial neoplasia, but only in the context of PI3-kinase pathway activation mediated by either Pten loss or Akt activation. They also find that human TMPRSS2-ERG–positive tumors are enriched for PTEN loss, suggesting that these two events cooperate in human prostate tumorigenesis. The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG–positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis." @default.
• W2049205984 created "2016-06-24" @default.
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• W2049205984 date "2009-04-26" @default.
• W2049205984 modified "2023-10-07" @default.
• W2049205984 title "Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis" @default.
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• W2049205984 doi "https://doi.org/10.1038/ng.371" @default.
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