FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049206096> ?p ?o ?g. }

• W2049206096 endingPage "e50923" @default.
• W2049206096 startingPage "e50923" @default.
• W2049206096 abstract "T-cells play an important role controlling immunity against pathogens and therefore influence the outcome of human diseases. Although most T-lymphocytes co-express either CD4 or CD8, a smaller T-cell subset found the in the human peripheral blood that expresses the αβ or γδ T-cell-receptor (TCR) lacks the CD4 and CD8 co-receptors. These double negative (DN) T-cells have been shown to display important immunological functions in human diseases. To better understand the role of DN T-cells in human Mycobacterium tuberculosis, we have characterized their frequency, activation and cytokine profile in a well-defined group of tuberculosis patients, categorized as severe and non-severe based on their clinical status. Our data showed that whereas high frequency of αβ DN T-cells observed in M. tuberculosis-infected patients are associated with disease severity, decreased proportion of γδ DN T-cells are found in patients with severe tuberculosis. Together with activation of CD4(+) and CD8(+) T-cells, higher frequencies of both αβ and γδ DN T-cells from tuberculosis patients also express the chronic activation marker HLA-DR. However, the expression of CD69, an early activation marker, is selectively observed in DN T-cells. Interestingly, while αβ and γδ DN T-cells from patients with non-severe tuberculosis display a pro-inflammatory cytokine profile, characterized by enhanced IFN-γ, the γδ DN T-cells from patients with severe disease express a modulatory profile exemplified by enhanced interleukin-10 production. Overall, our findings suggest that αβ and γδ DN T-cell present disparate immunoregulatory potentials and seems to contribute to the development/maintenance of distinct clinical aspects of TB, as part of the complex immunological network triggered by the TB infection." @default.
• W2049206096 created "2016-06-24" @default.
• W2049206096 creator A5017523406 @default.
• W2049206096 creator A5020614059 @default.
• W2049206096 creator A5022976564 @default.
• W2049206096 creator A5054733762 @default.
• W2049206096 creator A5061904118 @default.
• W2049206096 creator A5077737837 @default.
• W2049206096 creator A5079356496 @default.
• W2049206096 creator A5089614667 @default.
• W2049206096 creator A5091361431 @default.
• W2049206096 date "2012-12-11" @default.
• W2049206096 modified "2023-10-14" @default.
• W2049206096 title "CD4-CD8-αβ and γδ T Cells Display Inflammatory and Regulatory Potentials during Human Tuberculosis" @default.
• W2049206096 cites W1572276219 @default.
• W2049206096 cites W1984429004 @default.
• W2049206096 cites W1984766105 @default.
• W2049206096 cites W1985695716 @default.
• W2049206096 cites W1985784674 @default.
• W2049206096 cites W1992318576 @default.
• W2049206096 cites W1992551577 @default.
• W2049206096 cites W2006201065 @default.
• W2049206096 cites W2013829686 @default.
• W2049206096 cites W2020365793 @default.
• W2049206096 cites W2025227171 @default.
• W2049206096 cites W2026270989 @default.
• W2049206096 cites W2038535814 @default.
• W2049206096 cites W2057505085 @default.
• W2049206096 cites W2058910688 @default.
• W2049206096 cites W2062811890 @default.
• W2049206096 cites W2065791817 @default.
• W2049206096 cites W2074895894 @default.
• W2049206096 cites W2082734149 @default.
• W2049206096 cites W2091328187 @default.
• W2049206096 cites W2097410798 @default.
• W2049206096 cites W2098700395 @default.
• W2049206096 cites W2104941073 @default.
• W2049206096 cites W2105031128 @default.
• W2049206096 cites W2110301209 @default.
• W2049206096 cites W2110807603 @default.
• W2049206096 cites W2113225407 @default.
• W2049206096 cites W2114723202 @default.
• W2049206096 cites W2116723397 @default.
• W2049206096 cites W2120326154 @default.
• W2049206096 cites W2129996072 @default.
• W2049206096 cites W2142535120 @default.
• W2049206096 cites W2144926920 @default.
• W2049206096 cites W2145036226 @default.
• W2049206096 cites W2146520262 @default.
• W2049206096 cites W2156964805 @default.
• W2049206096 cites W2159031134 @default.
• W2049206096 cites W2170450192 @default.
• W2049206096 cites W2335678767 @default.
• W2049206096 cites W2342912071 @default.
• W2049206096 doi "https://doi.org/10.1371/journal.pone.0050923" @default.
• W2049206096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3519797" @default.
• W2049206096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23239994" @default.
• W2049206096 hasPublicationYear "2012" @default.
• W2049206096 type Work @default.
• W2049206096 sameAs 2049206096 @default.
• W2049206096 citedByCount "44" @default.
• W2049206096 countsByYear W20492060962013 @default.
• W2049206096 countsByYear W20492060962014 @default.
• W2049206096 countsByYear W20492060962015 @default.
• W2049206096 countsByYear W20492060962016 @default.
• W2049206096 countsByYear W20492060962017 @default.
• W2049206096 countsByYear W20492060962018 @default.
• W2049206096 countsByYear W20492060962019 @default.
• W2049206096 countsByYear W20492060962020 @default.
• W2049206096 countsByYear W20492060962021 @default.
• W2049206096 countsByYear W20492060962022 @default.
• W2049206096 countsByYear W20492060962023 @default.
• W2049206096 crossrefType "journal-article" @default.
• W2049206096 hasAuthorship W2049206096A5017523406 @default.
• W2049206096 hasAuthorship W2049206096A5020614059 @default.
• W2049206096 hasAuthorship W2049206096A5022976564 @default.
• W2049206096 hasAuthorship W2049206096A5054733762 @default.
• W2049206096 hasAuthorship W2049206096A5061904118 @default.
• W2049206096 hasAuthorship W2049206096A5077737837 @default.
• W2049206096 hasAuthorship W2049206096A5079356496 @default.
• W2049206096 hasAuthorship W2049206096A5089614667 @default.
• W2049206096 hasAuthorship W2049206096A5091361431 @default.
• W2049206096 hasBestOaLocation W20492060961 @default.
• W2049206096 hasConcept C142724271 @default.
• W2049206096 hasConcept C154317977 @default.
• W2049206096 hasConcept C167672396 @default.
• W2049206096 hasConcept C19317047 @default.
• W2049206096 hasConcept C202751555 @default.
• W2049206096 hasConcept C203014093 @default.
• W2049206096 hasConcept C2776090121 @default.
• W2049206096 hasConcept C2777975735 @default.
• W2049206096 hasConcept C2778690821 @default.
• W2049206096 hasConcept C2781069245 @default.
• W2049206096 hasConcept C54355233 @default.
• W2049206096 hasConcept C71924100 @default.
• W2049206096 hasConcept C86803240 @default.
• W2049206096 hasConcept C8891405 @default.
• W2049206096 hasConceptScore W2049206096C142724271 @default.

• next