Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049206765> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2049206765 endingPage "175" @default.
- W2049206765 startingPage "167" @default.
- W2049206765 abstract "This study has investigated the relative importance of central nervous and peripheral nitroxidergic mechanisms in the control of pyloric motility. In 10 urethane‐anaesthetized ferrets, drugs were administered directly to the CNS via a 0.5‐mm‐diameter cannula inserted into the 4th ventricle, approximately at the obex. Drugs were also given directly to the upper GI tract by close intra‐arterial (i.a.) injection at the coeliac axis. Antropyloroduodenal pressures were recorded with a five‐channel sleeve/sidehole micromanometric assembly (1.35 × 1.75 mm o.d.), which was introduced via the duodenum. Pyloric motility was stimulated throughout the main part of each study with a continuous i.v. infusion of CCK‐8 (30 pmol min −1 ). This infusion produced an immediate and sustained increase in tonic and phasic pyloric activity, and sustained abolition of antral pressure waves. CCK‐8 also induced a duodenal motor response, but this was short‐lived (11.4 ± 7.9 min). Coeliac axis injection of the NO donor S‐nitroso‐N‐acetyl‐penicillamine (SNAP) decreased phasic pyloric activity (from 330 ± 35 to 148 ± 21 mmHg min −1 after SNAP 5 μg, P < 0.01). By comparison, central SNAP administration over the same dose range had no effect on CCK‐stimulated pyloric motility. Inhibition of endogenous NO synthase with L‐Nitro Arginine Methyl Ester (L‐NAME, 100 mg kg −1 close i.a.) caused a marked increase of phasic pyloric motor activity from 349 ± 59 to 1044 ± 140 mmHg min −1 (P < 0.01). In addition, SNAP caused marked stimulation of pyloric tone from 2.6 ± 0.5 to 13.1 ± 2.8 mmHg (P < 0.01). Central nervous administration of L‐NAME caused modest enhancement of phasic pyloric activity (248 ± 31 to 283 ± 32 mmHg min −1 P < 0.05) and pyloric tone (2.6 ± 0.5 to 3.7 ± 0.7 mmHg, P < 0.05). Our data indicate that motor activity of the ferret pylorus is potently modulated by NO released within the upper gut. Additionally, there is potential for modulation of pyloric motility by central nervous system production of NO." @default.
- W2049206765 created "2016-06-24" @default.
- W2049206765 creator A5003000416 @default.
- W2049206765 creator A5019126848 @default.
- W2049206765 creator A5021376332 @default.
- W2049206765 date "1997-09-01" @default.
- W2049206765 modified "2023-10-17" @default.
- W2049206765 title "Pyloric motor response to central and peripheral nitric oxide in the ferret" @default.
- W2049206765 cites W1626510770 @default.
- W2049206765 cites W1924396214 @default.
- W2049206765 cites W1945050693 @default.
- W2049206765 cites W1966322594 @default.
- W2049206765 cites W1995418515 @default.
- W2049206765 cites W2016873507 @default.
- W2049206765 cites W2038978204 @default.
- W2049206765 cites W2050225094 @default.
- W2049206765 cites W2053271180 @default.
- W2049206765 cites W2062785215 @default.
- W2049206765 cites W2071864274 @default.
- W2049206765 cites W2079088549 @default.
- W2049206765 cites W2079608193 @default.
- W2049206765 cites W2084398452 @default.
- W2049206765 cites W2087217218 @default.
- W2049206765 cites W2136348956 @default.
- W2049206765 cites W2149995120 @default.
- W2049206765 cites W2157434392 @default.
- W2049206765 cites W2179381386 @default.
- W2049206765 cites W2210811561 @default.
- W2049206765 cites W2271192767 @default.
- W2049206765 cites W2338448492 @default.
- W2049206765 cites W2427994793 @default.
- W2049206765 doi "https://doi.org/10.1046/j.1365-2982.1997.d01-39.x" @default.
- W2049206765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9347472" @default.
- W2049206765 hasPublicationYear "1997" @default.
- W2049206765 type Work @default.
- W2049206765 sameAs 2049206765 @default.
- W2049206765 citedByCount "15" @default.
- W2049206765 countsByYear W20492067652014 @default.
- W2049206765 countsByYear W20492067652015 @default.
- W2049206765 countsByYear W20492067652023 @default.
- W2049206765 crossrefType "journal-article" @default.
- W2049206765 hasAuthorship W2049206765A5003000416 @default.
- W2049206765 hasAuthorship W2049206765A5019126848 @default.
- W2049206765 hasAuthorship W2049206765A5021376332 @default.
- W2049206765 hasConcept C126322002 @default.
- W2049206765 hasConcept C131253125 @default.
- W2049206765 hasConcept C134018914 @default.
- W2049206765 hasConcept C141071460 @default.
- W2049206765 hasConcept C185592680 @default.
- W2049206765 hasConcept C2776809568 @default.
- W2049206765 hasConcept C2778012502 @default.
- W2049206765 hasConcept C2778074680 @default.
- W2049206765 hasConcept C2778921608 @default.
- W2049206765 hasConcept C2779422922 @default.
- W2049206765 hasConcept C35147842 @default.
- W2049206765 hasConcept C42219234 @default.
- W2049206765 hasConcept C54355233 @default.
- W2049206765 hasConcept C58207958 @default.
- W2049206765 hasConcept C71924100 @default.
- W2049206765 hasConcept C86803240 @default.
- W2049206765 hasConceptScore W2049206765C126322002 @default.
- W2049206765 hasConceptScore W2049206765C131253125 @default.
- W2049206765 hasConceptScore W2049206765C134018914 @default.
- W2049206765 hasConceptScore W2049206765C141071460 @default.
- W2049206765 hasConceptScore W2049206765C185592680 @default.
- W2049206765 hasConceptScore W2049206765C2776809568 @default.
- W2049206765 hasConceptScore W2049206765C2778012502 @default.
- W2049206765 hasConceptScore W2049206765C2778074680 @default.
- W2049206765 hasConceptScore W2049206765C2778921608 @default.
- W2049206765 hasConceptScore W2049206765C2779422922 @default.
- W2049206765 hasConceptScore W2049206765C35147842 @default.
- W2049206765 hasConceptScore W2049206765C42219234 @default.
- W2049206765 hasConceptScore W2049206765C54355233 @default.
- W2049206765 hasConceptScore W2049206765C58207958 @default.
- W2049206765 hasConceptScore W2049206765C71924100 @default.
- W2049206765 hasConceptScore W2049206765C86803240 @default.
- W2049206765 hasIssue "3" @default.
- W2049206765 hasLocation W20492067651 @default.
- W2049206765 hasLocation W20492067652 @default.
- W2049206765 hasOpenAccess W2049206765 @default.
- W2049206765 hasPrimaryLocation W20492067651 @default.
- W2049206765 hasRelatedWork W1943478620 @default.
- W2049206765 hasRelatedWork W1996398102 @default.
- W2049206765 hasRelatedWork W2087160035 @default.
- W2049206765 hasRelatedWork W2091083775 @default.
- W2049206765 hasRelatedWork W2112768639 @default.
- W2049206765 hasRelatedWork W2148179192 @default.
- W2049206765 hasRelatedWork W2149214551 @default.
- W2049206765 hasRelatedWork W2212254821 @default.
- W2049206765 hasRelatedWork W2399780429 @default.
- W2049206765 hasRelatedWork W2803260963 @default.
- W2049206765 hasVolume "9" @default.
- W2049206765 isParatext "false" @default.
- W2049206765 isRetracted "false" @default.
- W2049206765 magId "2049206765" @default.
- W2049206765 workType "article" @default.