FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049206904> ?p ?o ?g. }

• W2049206904 endingPage "2142" @default.
• W2049206904 startingPage "2134" @default.
• W2049206904 abstract "This study investigates the relation between myocardial oxygen consumption (MVO2), function, and high energy phosphates during severe hypoxia and reoxygenation in sheep in vivo. Graded hypoxia was performed in open-chested sheep to adjust PO2 to values where rapid depletion of energy stores occurred. Highly time-resolved 31P nuclear magnetic resonance spectroscopy enabled monitoring of myocardial phosphates throughout hypoxia and recovery with simultaneous MVO2 measurement. Sheep undergoing graded hypoxia (n = 5) with an arterial PO2 nadir of 13.4 +/- 0.5 mmHg, demonstrated maintained rates of oxygen consumption with large changes in coronary flow as phosphocreatine (PCr) decreased within 4 min to 40 +/- 7% of baseline. ATP utilization rate increased simultaneously 59 +/- 20%. Recovery was accompanied by marked increases in MVO2 from 2.0 +/- 0.5 to 7.2 +/- 1.9 mumol/g per min, while PCr recovery rate was 4.3 +/- 0.6 mumol/g per min. ATP decreased to 75 +/- 6% of baseline during severe hypoxia and did not recover. Sheep (n = 5) which underwent moderate hypoxia (PO2 maintained 25-35 mmHg for 10 min) did not demonstrate change in PCr or ATP. Functional and work assessment (n = 4) revealed that cardiac power increased during the graded hypoxia and was maintained through early reoxygenation. These studies show that (a) MVO2 does not decrease during oxygen deprivation in vivo despite marked and rapid decreases in high energy phosphates; (b) contractile function during hypoxia in vivo does not decrease during periods of PCr depletion and intracellular phosphate accumulation, and this may be related to marked increases in circulating catecholamines during global hypoxia. The measured creatine rephosphorylation rate is 34 +/- 11% of predicted (P < 0.01) calculated from reoxygenation parameters, which indicates that some mitochondrial respiratory uncoupling also occurs during the rephosphorylation period." @default.
• W2049206904 created "2016-06-24" @default.
• W2049206904 creator A5021626585 @default.
• W2049206904 creator A5059620757 @default.
• W2049206904 creator A5072572343 @default.
• W2049206904 date "1995-05-01" @default.
• W2049206904 modified "2023-09-26" @default.
• W2049206904 title "Relation of myocardial oxygen consumption and function to high energy phosphate utilization during graded hypoxia and reoxygenation in sheep in vivo." @default.
• W2049206904 cites W10629607 @default.
• W2049206904 cites W1504836130 @default.
• W2049206904 cites W1512854463 @default.
• W2049206904 cites W1595986566 @default.
• W2049206904 cites W1603109630 @default.
• W2049206904 cites W1865875566 @default.
• W2049206904 cites W1912054520 @default.
• W2049206904 cites W1975365428 @default.
• W2049206904 cites W1976830811 @default.
• W2049206904 cites W1989751364 @default.
• W2049206904 cites W1990220729 @default.
• W2049206904 cites W1992408134 @default.
• W2049206904 cites W2002620791 @default.
• W2049206904 cites W2003598390 @default.
• W2049206904 cites W2010303116 @default.
• W2049206904 cites W2015988658 @default.
• W2049206904 cites W2022043476 @default.
• W2049206904 cites W2025975686 @default.
• W2049206904 cites W2028919376 @default.
• W2049206904 cites W2031001028 @default.
• W2049206904 cites W2031704363 @default.
• W2049206904 cites W2032192346 @default.
• W2049206904 cites W2034293407 @default.
• W2049206904 cites W2054989425 @default.
• W2049206904 cites W2057969898 @default.
• W2049206904 cites W2059674506 @default.
• W2049206904 cites W2060376037 @default.
• W2049206904 cites W2077163172 @default.
• W2049206904 cites W2077768674 @default.
• W2049206904 cites W2081651316 @default.
• W2049206904 cites W2089013259 @default.
• W2049206904 cites W2093893651 @default.
• W2049206904 cites W2117631539 @default.
• W2049206904 cites W2133446201 @default.
• W2049206904 cites W2144002329 @default.
• W2049206904 cites W2156682207 @default.
• W2049206904 cites W2197304610 @default.
• W2049206904 cites W2210401360 @default.
• W2049206904 cites W2310697543 @default.
• W2049206904 cites W2342164168 @default.
• W2049206904 cites W2404483770 @default.
• W2049206904 cites W2411854062 @default.
• W2049206904 cites W2415331643 @default.
• W2049206904 cites W2418732909 @default.
• W2049206904 cites W2468748379 @default.
• W2049206904 doi "https://doi.org/10.1172/jci117902" @default.
• W2049206904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/295813" @default.
• W2049206904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7738181" @default.
• W2049206904 hasPublicationYear "1995" @default.
• W2049206904 type Work @default.
• W2049206904 sameAs 2049206904 @default.
• W2049206904 citedByCount "25" @default.
• W2049206904 countsByYear W20492069042012 @default.
• W2049206904 countsByYear W20492069042013 @default.
• W2049206904 countsByYear W20492069042014 @default.
• W2049206904 countsByYear W20492069042015 @default.
• W2049206904 countsByYear W20492069042021 @default.
• W2049206904 countsByYear W20492069042022 @default.
• W2049206904 crossrefType "journal-article" @default.
• W2049206904 hasAuthorship W2049206904A5021626585 @default.
• W2049206904 hasAuthorship W2049206904A5059620757 @default.
• W2049206904 hasAuthorship W2049206904A5072572343 @default.
• W2049206904 hasBestOaLocation W20492069041 @default.
• W2049206904 hasConcept C126322002 @default.
• W2049206904 hasConcept C134018914 @default.
• W2049206904 hasConcept C150903083 @default.
• W2049206904 hasConcept C178790620 @default.
• W2049206904 hasConcept C185592680 @default.
• W2049206904 hasConcept C207001950 @default.
• W2049206904 hasConcept C2777132085 @default.
• W2049206904 hasConcept C2778273184 @default.
• W2049206904 hasConcept C2778626300 @default.
• W2049206904 hasConcept C2986317502 @default.
• W2049206904 hasConcept C540031477 @default.
• W2049206904 hasConcept C55493867 @default.
• W2049206904 hasConcept C71924100 @default.
• W2049206904 hasConcept C7836513 @default.
• W2049206904 hasConcept C86803240 @default.
• W2049206904 hasConceptScore W2049206904C126322002 @default.
• W2049206904 hasConceptScore W2049206904C134018914 @default.
• W2049206904 hasConceptScore W2049206904C150903083 @default.
• W2049206904 hasConceptScore W2049206904C178790620 @default.
• W2049206904 hasConceptScore W2049206904C185592680 @default.
• W2049206904 hasConceptScore W2049206904C207001950 @default.
• W2049206904 hasConceptScore W2049206904C2777132085 @default.
• W2049206904 hasConceptScore W2049206904C2778273184 @default.
• W2049206904 hasConceptScore W2049206904C2778626300 @default.
• W2049206904 hasConceptScore W2049206904C2986317502 @default.
• W2049206904 hasConceptScore W2049206904C540031477 @default.
• W2049206904 hasConceptScore W2049206904C55493867 @default.

• next