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• W2049208989 abstract "Stochastic epigenetic changes drive biological processes, such as development, aging and disease. Yet, epigenetic information is typically collected from millions of cells, thereby precluding a more precise understanding of cell-to-cell variability and the pathogenic history of epimutations. Here we present a novel procedure for directly detecting epimutations in DNA methylation patterns using single-cell, locus-specific bisulfite sequencing (SLBS). We show that within gene promoter regions of mouse hepatocytes the epimutation rate is two orders of magnitude higher than the mutation rate." @default.
• W2049208989 created "2016-06-24" @default.
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• W2049208989 date "2015-04-19" @default.
• W2049208989 modified "2023-10-18" @default.
• W2049208989 title "Single-cell, locus-specific bisulfite sequencing (SLBS) for direct detection of epimutations in DNA methylation patterns" @default.
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• W2049208989 doi "https://doi.org/10.1093/nar/gkv366" @default.
• W2049208989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4538804" @default.
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