Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049212044> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2049212044 endingPage "S19" @default.
- W2049212044 startingPage "S12" @default.
- W2049212044 abstract "Hypertension is a risk factor for the development of atherosclerosis and its complications, which are among the major causes of morbidity and mortality. Although recent clinical trials indicate that antihypertensive treatment reduces morbidity and mortality associated with stroke, congestive heart failure, and renal insufficiency, questions remain as to whether such treatment also prevents coronary heart disease (CHD) mortality. The observed reduction in CHD mortality from pooled clinical trial data was 10–14% and was much less than the expected 20–25%, reduction for a 5–6 mm Hg reduction in diastolic pressure. One explanation may he that subtle adverse metabolic effects of treatment may have blunted the beneficial effects. Isradipine, a dihydropyridine calcium antagonist, is a potent antihypertensive drug with antiatherogenic properties in animal models. Therefore, we hypothesized that isradipine may he appropriate for testing the efficacy of antihypertensive treatment in retarding the progression of atherosclerosis in humans. The Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS) is a clinical trial designed to compare the efficacy of isradipine (2.5 or 5 mg b.i.d.) with hydrochlorothiazide (12.5 or 25 mg b.i.d.) in retarding the progression of early carotid atherosclerosis as monitored by high-resolution B-mode ultrasonography." @default.
- W2049212044 created "2016-06-24" @default.
- W2049212044 creator A5001968810 @default.
- W2049212044 creator A5016386227 @default.
- W2049212044 creator A5024082467 @default.
- W2049212044 creator A5059656780 @default.
- W2049212044 creator A5063990946 @default.
- W2049212044 creator A5065880867 @default.
- W2049212044 creator A5080584791 @default.
- W2049212044 date "1991-01-01" @default.
- W2049212044 modified "2023-09-25" @default.
- W2049212044 title "The Multicenter Isradipine/Diuretic Atherosclerosis Study" @default.
- W2049212044 doi "https://doi.org/10.1097/00005344-199100183-00007" @default.
- W2049212044 hasPublicationYear "1991" @default.
- W2049212044 type Work @default.
- W2049212044 sameAs 2049212044 @default.
- W2049212044 citedByCount "4" @default.
- W2049212044 crossrefType "journal-article" @default.
- W2049212044 hasAuthorship W2049212044A5001968810 @default.
- W2049212044 hasAuthorship W2049212044A5016386227 @default.
- W2049212044 hasAuthorship W2049212044A5024082467 @default.
- W2049212044 hasAuthorship W2049212044A5059656780 @default.
- W2049212044 hasAuthorship W2049212044A5063990946 @default.
- W2049212044 hasAuthorship W2049212044A5065880867 @default.
- W2049212044 hasAuthorship W2049212044A5080584791 @default.
- W2049212044 hasBestOaLocation W20492120441 @default.
- W2049212044 hasConcept C126322002 @default.
- W2049212044 hasConcept C164705383 @default.
- W2049212044 hasConcept C2776066529 @default.
- W2049212044 hasConcept C2778198053 @default.
- W2049212044 hasConcept C2779918671 @default.
- W2049212044 hasConcept C2780361556 @default.
- W2049212044 hasConcept C2781212610 @default.
- W2049212044 hasConcept C519063684 @default.
- W2049212044 hasConcept C535046627 @default.
- W2049212044 hasConcept C71924100 @default.
- W2049212044 hasConcept C84393581 @default.
- W2049212044 hasConcept C98274493 @default.
- W2049212044 hasConceptScore W2049212044C126322002 @default.
- W2049212044 hasConceptScore W2049212044C164705383 @default.
- W2049212044 hasConceptScore W2049212044C2776066529 @default.
- W2049212044 hasConceptScore W2049212044C2778198053 @default.
- W2049212044 hasConceptScore W2049212044C2779918671 @default.
- W2049212044 hasConceptScore W2049212044C2780361556 @default.
- W2049212044 hasConceptScore W2049212044C2781212610 @default.
- W2049212044 hasConceptScore W2049212044C519063684 @default.
- W2049212044 hasConceptScore W2049212044C535046627 @default.
- W2049212044 hasConceptScore W2049212044C71924100 @default.
- W2049212044 hasConceptScore W2049212044C84393581 @default.
- W2049212044 hasConceptScore W2049212044C98274493 @default.
- W2049212044 hasLocation W20492120441 @default.
- W2049212044 hasLocation W20492120442 @default.
- W2049212044 hasOpenAccess W2049212044 @default.
- W2049212044 hasPrimaryLocation W20492120441 @default.
- W2049212044 hasRelatedWork W2009438838 @default.
- W2049212044 hasRelatedWork W2081121948 @default.
- W2049212044 hasRelatedWork W2083409742 @default.
- W2049212044 hasRelatedWork W2129455235 @default.
- W2049212044 hasRelatedWork W2398250315 @default.
- W2049212044 hasRelatedWork W2410347839 @default.
- W2049212044 hasRelatedWork W2414121678 @default.
- W2049212044 hasRelatedWork W2432715276 @default.
- W2049212044 hasRelatedWork W611683248 @default.
- W2049212044 hasRelatedWork W4290178206 @default.
- W2049212044 hasVolume "18" @default.
- W2049212044 isParatext "false" @default.
- W2049212044 isRetracted "false" @default.
- W2049212044 magId "2049212044" @default.
- W2049212044 workType "article" @default.