Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049227315> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2049227315 endingPage "985" @default.
- W2049227315 startingPage "979" @default.
- W2049227315 abstract "We have studied the roles of nicotinic and muscarinic receptors in the acetylcholine-evoked secretion of catecholamine from guinea-pig chromaffin cells. Isolated guinea-pig chromaffin cells secrete catecholamine in response to acetylcholine, nicotine, and a variety of muscarinic agonists. Optimal concentrations of acetylcholine (50–200 μM) induce the release of 10–25% of the catecholamine content of the cells in 10 min. Maximal secretion evoked by nicotine or by muscarinic agonists is 5–12% of the catecholamine content of the cells. Secretion evoked by optimal concentrations of nicotine (50 μM) and muscarine (200 μM) are additive, and together these agonists cause catecholamine release equivalent to that produced by optimal concentrations of acetylcholine. Atropine causes a biphasic inhibition of acetylcholine-induced catecholamine secretion; low concentrations of atropine (0.02–0.1 μM) inhibit by 35–45% the catecholamine secretion evoked by 100 μM acetylcholine. Increasing the atropine concentration from 0.1 to 5 μM causes no further decrease in acetylcholine-evoked release, but at concentrations above 5 μM, a second distinct phase of inhibition appears. At 100 μM, atropine reduces acetylcholine-evoked secretion by 85%. At 0.1 μM, atropine significantly inhibits secretion induced by muscarinic, but not nicotinic, agonists. Tubocurarine (50 μM) does not block muscarinic stimulation of release, but inhibits acetylcholine- and nicotine-evoked release by 70 and 80%, respectively. Our experiments indicate that nicotinic and muscarinic stimulation represent distinct mechanisms for the activation of catecholamine release from guinea-pig chromaffin cells. Acetylcholine causes secretion by both of these pathways. Nicotinic stimulation accounts for approximately 60–70% of the release caused by 100 μM acetylcholine; the remaining 30–40% of the acetylcholine-evoked release is mediated by muscarinic receptors." @default.
- W2049227315 created "2016-06-24" @default.
- W2049227315 creator A5035655126 @default.
- W2049227315 creator A5053382593 @default.
- W2049227315 date "1983-10-01" @default.
- W2049227315 modified "2023-09-25" @default.
- W2049227315 title "Both nicotinic and muscarinic receptors mediate catecholamine secretion by isolated guinea-pig chromaffin cells" @default.
- W2049227315 cites W156443540 @default.
- W2049227315 cites W1985214365 @default.
- W2049227315 cites W1989688933 @default.
- W2049227315 cites W2009276840 @default.
- W2049227315 cites W2022641758 @default.
- W2049227315 cites W2032673696 @default.
- W2049227315 cites W2038389631 @default.
- W2049227315 cites W2041126251 @default.
- W2049227315 cites W2062982378 @default.
- W2049227315 cites W2065580243 @default.
- W2049227315 cites W2069667813 @default.
- W2049227315 cites W2069998663 @default.
- W2049227315 cites W2090486706 @default.
- W2049227315 cites W2092134407 @default.
- W2049227315 cites W2092991823 @default.
- W2049227315 cites W2106995929 @default.
- W2049227315 doi "https://doi.org/10.1016/0306-4522(83)90236-1" @default.
- W2049227315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6646440" @default.
- W2049227315 hasPublicationYear "1983" @default.
- W2049227315 type Work @default.
- W2049227315 sameAs 2049227315 @default.
- W2049227315 citedByCount "57" @default.
- W2049227315 countsByYear W20492273152017 @default.
- W2049227315 countsByYear W20492273152019 @default.
- W2049227315 countsByYear W20492273152020 @default.
- W2049227315 crossrefType "journal-article" @default.
- W2049227315 hasAuthorship W2049227315A5035655126 @default.
- W2049227315 hasAuthorship W2049227315A5053382593 @default.
- W2049227315 hasConcept C116289061 @default.
- W2049227315 hasConcept C126322002 @default.
- W2049227315 hasConcept C134018914 @default.
- W2049227315 hasConcept C170493617 @default.
- W2049227315 hasConcept C185592680 @default.
- W2049227315 hasConcept C188987157 @default.
- W2049227315 hasConcept C22885893 @default.
- W2049227315 hasConcept C2775859210 @default.
- W2049227315 hasConcept C2775894120 @default.
- W2049227315 hasConcept C2775910092 @default.
- W2049227315 hasConcept C2777597313 @default.
- W2049227315 hasConcept C2779547902 @default.
- W2049227315 hasConcept C2780841807 @default.
- W2049227315 hasConcept C2780910648 @default.
- W2049227315 hasConcept C33789571 @default.
- W2049227315 hasConcept C64123433 @default.
- W2049227315 hasConcept C71924100 @default.
- W2049227315 hasConcept C86803240 @default.
- W2049227315 hasConceptScore W2049227315C116289061 @default.
- W2049227315 hasConceptScore W2049227315C126322002 @default.
- W2049227315 hasConceptScore W2049227315C134018914 @default.
- W2049227315 hasConceptScore W2049227315C170493617 @default.
- W2049227315 hasConceptScore W2049227315C185592680 @default.
- W2049227315 hasConceptScore W2049227315C188987157 @default.
- W2049227315 hasConceptScore W2049227315C22885893 @default.
- W2049227315 hasConceptScore W2049227315C2775859210 @default.
- W2049227315 hasConceptScore W2049227315C2775894120 @default.
- W2049227315 hasConceptScore W2049227315C2775910092 @default.
- W2049227315 hasConceptScore W2049227315C2777597313 @default.
- W2049227315 hasConceptScore W2049227315C2779547902 @default.
- W2049227315 hasConceptScore W2049227315C2780841807 @default.
- W2049227315 hasConceptScore W2049227315C2780910648 @default.
- W2049227315 hasConceptScore W2049227315C33789571 @default.
- W2049227315 hasConceptScore W2049227315C64123433 @default.
- W2049227315 hasConceptScore W2049227315C71924100 @default.
- W2049227315 hasConceptScore W2049227315C86803240 @default.
- W2049227315 hasIssue "3" @default.
- W2049227315 hasLocation W20492273151 @default.
- W2049227315 hasLocation W20492273152 @default.
- W2049227315 hasOpenAccess W2049227315 @default.
- W2049227315 hasPrimaryLocation W20492273151 @default.
- W2049227315 hasRelatedWork W1964860377 @default.
- W2049227315 hasRelatedWork W1979055604 @default.
- W2049227315 hasRelatedWork W2049227315 @default.
- W2049227315 hasRelatedWork W2051669115 @default.
- W2049227315 hasRelatedWork W2052918917 @default.
- W2049227315 hasRelatedWork W2089432906 @default.
- W2049227315 hasRelatedWork W224905747 @default.
- W2049227315 hasRelatedWork W2329805498 @default.
- W2049227315 hasRelatedWork W2413376362 @default.
- W2049227315 hasRelatedWork W4250866 @default.
- W2049227315 hasVolume "10" @default.
- W2049227315 isParatext "false" @default.
- W2049227315 isRetracted "false" @default.
- W2049227315 magId "2049227315" @default.
- W2049227315 workType "article" @default.