FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049231617> ?p ?o ?g. }

• W2049231617 endingPage "658" @default.
• W2049231617 startingPage "652" @default.
• W2049231617 abstract "Rationale: Sinoaortic denervated (SAD) and chemically sympathectomized (SNX) rats are characterized by a decrease in arterial distensibility without hypertension and would, thus, be relevant for analyzing arterial wall stiffening independently of blood pressure level. The fibronectin network, which plays a pivotal role in cell–matrix interactions, is a major determinant of arterial stiffness. We hypothesized that in SAD and SNX rats, arterial stiffness is increased, due to alterations of cell–matrix anchoring leading to spatial reorganization of the extracellular matrix. Methods: The intrinsic elastic properties of the arterial wall were evaluated in vivo by the relationship between incremental elastic modulus determined by echotracking and circumferential wall stress. The changes of cell-extracellular matrix links in the abdominal aorta were evaluated by studying fibronectin, vascular integrin receptors, and ultrastructural features of the aorta by immunochemistry. Results: In both experimental conditions, wall stiffness increased, associated with different modifications of cell-extracellular matrix adhesion. In SAD rats, increased media cross-sectional area was coupled with an increase of muscle cell attachments to its extracellular matrix via fibronectin and its α5-β1 integrin. In SNX rats, reduced media cross-sectional area was associated with upregulation of αv-β3 integrin and more extensive connections between dense bands and elastic fibers despite the disruption of the elastic lamellae. Conclusion: In aorta of SNX and SAD rats, a similar arterial stiffness is associated to different structural alterations. An increase in αvβ3 or α5β1 integrins together with the already reported increase in the proportion of less distensible (collagen) to more distensible (elastin) components in both models contributes to remodeling and stiffening of the abdominal aorta." @default.
• W2049231617 created "2016-06-24" @default.
• W2049231617 creator A5000947324 @default.
• W2049231617 creator A5022899189 @default.
• W2049231617 creator A5041120531 @default.
• W2049231617 creator A5041508066 @default.
• W2049231617 creator A5058101804 @default.
• W2049231617 creator A5059528190 @default.
• W2049231617 creator A5060757272 @default.
• W2049231617 creator A5087655089 @default.
• W2049231617 date "2014-03-01" @default.
• W2049231617 modified "2023-10-01" @default.
• W2049231617 title "Increased stiffness and cell–matrix interactions of abdominal aorta in two experimental nonhypertensive models" @default.
• W2049231617 cites W1978736086 @default.
• W2049231617 cites W1979049477 @default.
• W2049231617 cites W1994589849 @default.
• W2049231617 cites W2009280614 @default.
• W2049231617 cites W2017023029 @default.
• W2049231617 cites W2025120360 @default.
• W2049231617 cites W2052664911 @default.
• W2049231617 cites W2057192607 @default.
• W2049231617 cites W2069673715 @default.
• W2049231617 cites W2078014401 @default.
• W2049231617 cites W2080422776 @default.
• W2049231617 cites W2088953408 @default.
• W2049231617 cites W2100168858 @default.
• W2049231617 cites W2101100623 @default.
• W2049231617 cites W2104082168 @default.
• W2049231617 cites W2108397204 @default.
• W2049231617 cites W2108524239 @default.
• W2049231617 cites W2110849186 @default.
• W2049231617 cites W2116409362 @default.
• W2049231617 cites W2120402403 @default.
• W2049231617 cites W2122171574 @default.
• W2049231617 cites W2123832217 @default.
• W2049231617 cites W2125914602 @default.
• W2049231617 cites W2127606189 @default.
• W2049231617 cites W2141846029 @default.
• W2049231617 cites W2147138972 @default.
• W2049231617 cites W2148279786 @default.
• W2049231617 cites W2150215679 @default.
• W2049231617 doi "https://doi.org/10.1097/hjh.0000000000000073" @default.
• W2049231617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5097123" @default.
• W2049231617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24356541" @default.
• W2049231617 hasPublicationYear "2014" @default.
• W2049231617 type Work @default.
• W2049231617 sameAs 2049231617 @default.
• W2049231617 citedByCount "17" @default.
• W2049231617 countsByYear W20492316172014 @default.
• W2049231617 countsByYear W20492316172015 @default.
• W2049231617 countsByYear W20492316172016 @default.
• W2049231617 countsByYear W20492316172017 @default.
• W2049231617 countsByYear W20492316172019 @default.
• W2049231617 countsByYear W20492316172020 @default.
• W2049231617 countsByYear W20492316172021 @default.
• W2049231617 countsByYear W20492316172023 @default.
• W2049231617 crossrefType "journal-article" @default.
• W2049231617 hasAuthorship W2049231617A5000947324 @default.
• W2049231617 hasAuthorship W2049231617A5022899189 @default.
• W2049231617 hasAuthorship W2049231617A5041120531 @default.
• W2049231617 hasAuthorship W2049231617A5041508066 @default.
• W2049231617 hasAuthorship W2049231617A5058101804 @default.
• W2049231617 hasAuthorship W2049231617A5059528190 @default.
• W2049231617 hasAuthorship W2049231617A5060757272 @default.
• W2049231617 hasAuthorship W2049231617A5087655089 @default.
• W2049231617 hasBestOaLocation W20492316172 @default.
• W2049231617 hasConcept C105702510 @default.
• W2049231617 hasConcept C12554922 @default.
• W2049231617 hasConcept C126322002 @default.
• W2049231617 hasConcept C142724271 @default.
• W2049231617 hasConcept C1491633281 @default.
• W2049231617 hasConcept C170493617 @default.
• W2049231617 hasConcept C189165786 @default.
• W2049231617 hasConcept C195687474 @default.
• W2049231617 hasConcept C2775850156 @default.
• W2049231617 hasConcept C2779869378 @default.
• W2049231617 hasConcept C2779980429 @default.
• W2049231617 hasConcept C2780520971 @default.
• W2049231617 hasConcept C28406088 @default.
• W2049231617 hasConcept C55493867 @default.
• W2049231617 hasConcept C71924100 @default.
• W2049231617 hasConcept C84393581 @default.
• W2049231617 hasConcept C85789140 @default.
• W2049231617 hasConcept C86492073 @default.
• W2049231617 hasConcept C86803240 @default.
• W2049231617 hasConcept C95444343 @default.
• W2049231617 hasConceptScore W2049231617C105702510 @default.
• W2049231617 hasConceptScore W2049231617C12554922 @default.
• W2049231617 hasConceptScore W2049231617C126322002 @default.
• W2049231617 hasConceptScore W2049231617C142724271 @default.
• W2049231617 hasConceptScore W2049231617C1491633281 @default.
• W2049231617 hasConceptScore W2049231617C170493617 @default.
• W2049231617 hasConceptScore W2049231617C189165786 @default.
• W2049231617 hasConceptScore W2049231617C195687474 @default.
• W2049231617 hasConceptScore W2049231617C2775850156 @default.
• W2049231617 hasConceptScore W2049231617C2779869378 @default.
• W2049231617 hasConceptScore W2049231617C2779980429 @default.
• W2049231617 hasConceptScore W2049231617C2780520971 @default.

• next