FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049236625> ?p ?o ?g. }

• W2049236625 endingPage "174" @default.
• W2049236625 startingPage "167" @default.
• W2049236625 abstract "Cytosolic determinations of cathepsin-D (cath-D), urokinase plasminogen activator (uPA) and its specific inhibitor PAI-1 have shown an association with adverse prognosis in breast cancer. Our aim was to study the distribution of these markers in small axillary node-negative breast carcinomas using immunohistochemistry and relate the semiquantitative results to known prognostic factors, the expression of tenascin-C (Tn-C) in invasion border of the tumour and prognosis. All the 158 women (159 tumours) were treated with breast conserving surgery and postoperative radiotherapy. Cytoplasmic immunoreactivity for cath-D was seen in carcinoma cells in 47% and in stromal cells in 44%. Nearly all tumours expressed uPA and PAI-1, which were categorized to cytoplasmic expression in carcinoma cells and diffuse stromal expression and quantified – / + / ++ / +++ and further dichotomized for purposes of analysis. Expression of uPA and PAI-1 in stromal fibroblasts was recorded as – / +. Cytoplasmic and stromal cell cath-D contents were associated with grade, proliferation, Tn-C expression in the tumour invasion border and the development of distant metastasis. In multivariate analysis stromal cath-D proved to be an independent prognostic factor for metastasis. Stromal expression of uPA was associated with an increased risk of local recurrence; otherwise high levels of uPA did not associate with other prognostic factors nor with prognosis. Fibroblastic expression of PAI-1 showed an association with both local and distant disease recurrence. However, no consistent association between the immunohistochemically quantified uPA and PAI-1 and prognosis was found. In conclusion, immunohistochemical determination of cath-D seems to be a viable method to predict a higher risk of metastasis but not local recurrence in small axillary node-negative breast carcinomas." @default.
• W2049236625 created "2016-06-24" @default.
• W2049236625 creator A5006944340 @default.
• W2049236625 creator A5022218689 @default.
• W2049236625 creator A5057747602 @default.
• W2049236625 creator A5062149739 @default.
• W2049236625 creator A5067129653 @default.
• W2049236625 creator A5074435029 @default.
• W2049236625 date "1999-03-26" @default.
• W2049236625 modified "2023-10-08" @default.
• W2049236625 title "Cathepsin-D, urokinase plasminogen activator and type-1 plasminogen activator inhibitor in early breast cancer: an immunohistochemical study of prognostic value and relations to tenascin-C and other factors" @default.
• W2049236625 cites W1558913702 @default.
• W2049236625 cites W1689476148 @default.
• W2049236625 cites W1817657028 @default.
• W2049236625 cites W1890162005 @default.
• W2049236625 cites W1963579325 @default.
• W2049236625 cites W1965116477 @default.
• W2049236625 cites W1966719969 @default.
• W2049236625 cites W1967940704 @default.
• W2049236625 cites W1975717886 @default.
• W2049236625 cites W1977164339 @default.
• W2049236625 cites W1979498831 @default.
• W2049236625 cites W1986261554 @default.
• W2049236625 cites W1987829945 @default.
• W2049236625 cites W1990225759 @default.
• W2049236625 cites W1991711281 @default.
• W2049236625 cites W1991962266 @default.
• W2049236625 cites W1993367478 @default.
• W2049236625 cites W1995406904 @default.
• W2049236625 cites W2005617198 @default.
• W2049236625 cites W2008042551 @default.
• W2049236625 cites W2010500685 @default.
• W2049236625 cites W2014043577 @default.
• W2049236625 cites W2017129089 @default.
• W2049236625 cites W2020413441 @default.
• W2049236625 cites W2024058845 @default.
• W2049236625 cites W2024875639 @default.
• W2049236625 cites W2027833512 @default.
• W2049236625 cites W2029837224 @default.
• W2049236625 cites W2032827188 @default.
• W2049236625 cites W2036633666 @default.
• W2049236625 cites W2040544941 @default.
• W2049236625 cites W2043396483 @default.
• W2049236625 cites W2051300009 @default.
• W2049236625 cites W2051922225 @default.
• W2049236625 cites W2056474958 @default.
• W2049236625 cites W2078074277 @default.
• W2049236625 cites W2092018283 @default.
• W2049236625 cites W2110407293 @default.
• W2049236625 cites W2111924468 @default.
• W2049236625 cites W2120661962 @default.
• W2049236625 cites W2122177826 @default.
• W2049236625 cites W2135019338 @default.
• W2049236625 cites W2144775586 @default.
• W2049236625 cites W2150493842 @default.
• W2049236625 cites W2152541560 @default.
• W2049236625 cites W2157803226 @default.
• W2049236625 cites W2158095199 @default.
• W2049236625 cites W2158229538 @default.
• W2049236625 cites W2160895353 @default.
• W2049236625 cites W2200649958 @default.
• W2049236625 cites W23122061 @default.
• W2049236625 cites W2320016188 @default.
• W2049236625 cites W2326165980 @default.
• W2049236625 cites W2417390695 @default.
• W2049236625 cites W2922237950 @default.
• W2049236625 doi "https://doi.org/10.1038/sj.bjc.6690336" @default.
• W2049236625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2363020" @default.
• W2049236625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10389993" @default.
• W2049236625 hasPublicationYear "1999" @default.
• W2049236625 type Work @default.
• W2049236625 sameAs 2049236625 @default.
• W2049236625 citedByCount "33" @default.
• W2049236625 countsByYear W20492366252012 @default.
• W2049236625 countsByYear W20492366252013 @default.
• W2049236625 countsByYear W20492366252016 @default.
• W2049236625 countsByYear W20492366252017 @default.
• W2049236625 countsByYear W20492366252020 @default.
• W2049236625 crossrefType "journal-article" @default.
• W2049236625 hasAuthorship W2049236625A5006944340 @default.
• W2049236625 hasAuthorship W2049236625A5022218689 @default.
• W2049236625 hasAuthorship W2049236625A5057747602 @default.
• W2049236625 hasAuthorship W2049236625A5062149739 @default.
• W2049236625 hasAuthorship W2049236625A5067129653 @default.
• W2049236625 hasAuthorship W2049236625A5074435029 @default.
• W2049236625 hasBestOaLocation W20492366251 @default.
• W2049236625 hasConcept C121608353 @default.
• W2049236625 hasConcept C126322002 @default.
• W2049236625 hasConcept C142724271 @default.
• W2049236625 hasConcept C1491633281 @default.
• W2049236625 hasConcept C16930146 @default.
• W2049236625 hasConcept C173633252 @default.
• W2049236625 hasConcept C181199279 @default.
• W2049236625 hasConcept C204232928 @default.
• W2049236625 hasConcept C2777738151 @default.
• W2049236625 hasConcept C2779013556 @default.
• W2049236625 hasConcept C2779679481 @default.
• W2049236625 hasConcept C2780675426 @default.

• next