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- W2049247072 abstract "In prepulse inhibition (PPI), startle responses to sudden, unexpected stimuli are markedly attenuated if immediately preceded by a weak stimulus of almost any modality. This experimental paradigm exposes a potent inhibitory process, present in nervous systems from invertebrates to humans, that is widely considered to play an important role in reducing distraction during the processing of sensory input. The neural mechanisms mediating PPI are of considerable interest given evidence linking PPI deficits with some of the cognitive disorders of schizophrenia. Here, in the marine mollusk Tritonia diomedea, we describe a detailed cellular mechanism for PPI—a combination of presynaptic inhibition of startle afferent neurons together with distributed postsynaptic inhibition of several downstream interneuronal sites in the startle circuit." @default.
- W2049247072 created "2016-06-24" @default.
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- W2049247072 date "2003-12-01" @default.
- W2049247072 modified "2023-09-28" @default.
- W2049247072 title "A Cellular Mechanism for Prepulse Inhibition" @default.
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- W2049247072 doi "https://doi.org/10.1016/s0896-6273(03)00731-1" @default.
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