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• W2049256375 abstract "Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown.A senescence index (SI) was developed and used to retrospectively correlate the treatment outcome of 30 UICC stage IV colorectal cancer (CRC) patients with their SI at diagnosis.5-Fluorouracil/leucovorin-treated CRC patients achieved a significantly longer progression-free survival when presenting with SI-positive tumours before therapy (median 12.0 vs 6.0 months; P=0.044).Cancer cell senescence predicts treatment outcome in metastasised CRC. Prospective analyses of larger patient cohorts are needed." @default.
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• W2049256375 date "2010-07-13" @default.
• W2049256375 modified "2023-10-17" @default.
• W2049256375 title "Cellular senescence predicts treatment outcome in metastasised colorectal cancer" @default.
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• W2049256375 doi "https://doi.org/10.1038/sj.bjc.6605784" @default.
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