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- W2049263276 abstract "Nifedipine has been reported to cause impairment of insulin sensitivity. But recently a controlled-released formulation of nifedipine (nifedipine-GITS) has been reported that it could improve insulin sensitivity.We evaluated insulin sensitivity in two groups of essential hypertensive subjects before and after treatment with either long-acting nifedipine (nifedipine-CR, Adalat CR tablets; Bayer Yakuhin, Osaka, Japan) (n = 10) or metoprolol (n = 9). Insulin sensitivity was evaluated from the steady-state plasma glucose (SSPG) level measured at the steady-state insulin level (20 to 30 microU/mL) using a modification of the SSPG method previously reported.The SSPG was initially high, but was significantly reduced by nifedipine-CR treatment (from 133 +/- 14 mg/dL to 95 +/- 8 mg/dL). However, SSPG was not significantly altered by treatment in the metoprolol group (from 103 +/- 15 mg/dL to 119 +/- 12 mg/dL).Our results indicate that the long-acting nifedipine (nifedipine-CR) is associated with improved insulin sensitivity." @default.
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- W2049263276 date "2002-11-01" @default.
- W2049263276 modified "2023-10-17" @default.
- W2049263276 title "Improvement of insulin sensitivity by a long-acting nifedipine preparation (nifedipine-CR) in patients with essential hypertension" @default.
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- W2049263276 doi "https://doi.org/10.1016/s0895-7061(02)03019-4" @default.
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