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- W204926867 abstract "To examine the RB gene function in vivo, we established an RB-positive cell line, H-CL2, by transfecting the RB-negative human bladder carcinoma cell line, HTB9, with an RB expression vector. RB-positive H-CL2 cells grow in a serum-dependent manner and lack tumorigenicity in nude mice. At confluency, H-CL2 cells showed contact inhibition, whereas HTB9 cells continued to undergo cell division and detached from the plate within several hours. These detached cells were dye exclusive and fragmentation of nuclei was observed. In addition, DNA extracted from those cells showed ladder formation characteristic of apoptotic cells. In contrast, none of these phenomena was observed with H-CL2 following confluency. However, both H-CL2 and HTB9 cells expressed equally high levels of Fas antigen and had negative sensitivity to TNF. Serum stimulation of HTB9 resulted in increased c-myc expression followed by DNA synthesis, whereas no such increase in c-myc and DNA levels was observed in H-CL2 cells. These results suggest that RB protein expression prevents apoptosis of HTB9 cells through down-regulation of c-myc and suppression of DNA synthesis." @default.
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- W204926867 date "1994-09-01" @default.
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- W204926867 title "RB gene expression prevents apoptosis in an RB-negative cancer cell line" @default.
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