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- W2049270952 abstract "The thyroid was selected to test stability of morphological and physiological characters in vitro. Glands of 16-day chick embryos were dissociated with trypsin and Versene to destroy tissue organization. Immediate reaggregation and culture at the air-medium interface gave evidence on the ability of the cells to form these characters: follicles, colloid, and hormones plus precursors. Further disorganization was accomplished by culturing the suspensions as sheets in glass bottles, and differentiation was again tested by reaggregation and culturing at the air-medium interface. Colloid was stained for glycoprotein with the periodic acid-Schiff reaction, and iodinated compounds were separated chromatographically and visualized with the ceric sulfate-arsenious acid reagent. Aggregates of freshly dissociated cells formed new follicles, colloid, and hormone. Spreading cells lost only follicular organization and thyroxine but not intracellular glycoprotein and hormone precursors. These characters did not return upon reaggregation, nor when TSH was added to the aggregate nutrient medium. TSH did, however, increase the rate of glycoprotein formation in both types of aggregates. On the other hand, the combination of spreading thyroid fibroblasts and epithelial cells into the same aggregate resulted in the formation of some follicles and large amounts of extracellular colloid, but still no thyroxine. The significance of the results for the concept of cell stability is discussed." @default.
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- W2049270952 date "1962-02-01" @default.
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- W2049270952 title "The stability of embryonic chick thyroid cells in vitro as judged by morphological and physiological criteria" @default.
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- W2049270952 doi "https://doi.org/10.1016/0012-1606(62)90030-1" @default.
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