Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049271808> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2049271808 endingPage "281" @default.
- W2049271808 startingPage "273" @default.
- W2049271808 abstract "The nucleoside reverse transcriptase inhibitors (NRTIs) were the first class of agents used for the treatment of HIV and remain an important component of combination antiretroviral therapy. Resistance to the NRTIs occurs by the acquisition of mutations in the reverse transcriptase gene that result in a structural change that either decreases the NRTI incorporation into the extending nucleotide chain or enhances removal of the NRTI from the terminated chain, also known as primer unblocking or pyrophosphorylysis. There are several major genetic mutational patterns of resistance and cross-resistance that evolve with the NRTIs including the thymidine analog mutations M41L, D67N, K70R, L210W, T215Y, and K219Q/E/W, the non-thymidine mutations M184V, L74V, and K65R, and the multidrug resistant Q151M complex, as well as others. Increasing knowledge of resistance and cross-resistance patterns that evolve on the NRTIs as well as the other antiretroviral classes will help optimize antiretroviral treatment strategies. Advancing knowledge of the biochemical and structural basis of resistance will aid in the design of newer compounds that are active against HIV resistant to the currently available drugs, ultimately prolonging virologic suppression and life in the millions of people who are infected with HIV." @default.
- W2049271808 created "2016-06-24" @default.
- W2049271808 creator A5014907503 @default.
- W2049271808 creator A5018915738 @default.
- W2049271808 date "2003-12-01" @default.
- W2049271808 modified "2023-09-27" @default.
- W2049271808 title "A Review of HIV-1 Resistance to the Nucleoside and Nucleotide Inhibitors" @default.
- W2049271808 doi "https://doi.org/10.2174/1568005033481024" @default.
- W2049271808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14754429" @default.
- W2049271808 hasPublicationYear "2003" @default.
- W2049271808 type Work @default.
- W2049271808 sameAs 2049271808 @default.
- W2049271808 citedByCount "28" @default.
- W2049271808 countsByYear W20492718082013 @default.
- W2049271808 countsByYear W20492718082014 @default.
- W2049271808 countsByYear W20492718082015 @default.
- W2049271808 countsByYear W20492718082022 @default.
- W2049271808 countsByYear W20492718082023 @default.
- W2049271808 crossrefType "journal-article" @default.
- W2049271808 hasAuthorship W2049271808A5014907503 @default.
- W2049271808 hasAuthorship W2049271808A5018915738 @default.
- W2049271808 hasConcept C104317684 @default.
- W2049271808 hasConcept C114851261 @default.
- W2049271808 hasConcept C142462285 @default.
- W2049271808 hasConcept C156719811 @default.
- W2049271808 hasConcept C159047783 @default.
- W2049271808 hasConcept C178790620 @default.
- W2049271808 hasConcept C182707283 @default.
- W2049271808 hasConcept C185592680 @default.
- W2049271808 hasConcept C2776543447 @default.
- W2049271808 hasConcept C2777333352 @default.
- W2049271808 hasConcept C2777447569 @default.
- W2049271808 hasConcept C2777563447 @default.
- W2049271808 hasConcept C2909970146 @default.
- W2049271808 hasConcept C2993143319 @default.
- W2049271808 hasConcept C3013748606 @default.
- W2049271808 hasConcept C49105822 @default.
- W2049271808 hasConcept C54355233 @default.
- W2049271808 hasConcept C86803240 @default.
- W2049271808 hasConceptScore W2049271808C104317684 @default.
- W2049271808 hasConceptScore W2049271808C114851261 @default.
- W2049271808 hasConceptScore W2049271808C142462285 @default.
- W2049271808 hasConceptScore W2049271808C156719811 @default.
- W2049271808 hasConceptScore W2049271808C159047783 @default.
- W2049271808 hasConceptScore W2049271808C178790620 @default.
- W2049271808 hasConceptScore W2049271808C182707283 @default.
- W2049271808 hasConceptScore W2049271808C185592680 @default.
- W2049271808 hasConceptScore W2049271808C2776543447 @default.
- W2049271808 hasConceptScore W2049271808C2777333352 @default.
- W2049271808 hasConceptScore W2049271808C2777447569 @default.
- W2049271808 hasConceptScore W2049271808C2777563447 @default.
- W2049271808 hasConceptScore W2049271808C2909970146 @default.
- W2049271808 hasConceptScore W2049271808C2993143319 @default.
- W2049271808 hasConceptScore W2049271808C3013748606 @default.
- W2049271808 hasConceptScore W2049271808C49105822 @default.
- W2049271808 hasConceptScore W2049271808C54355233 @default.
- W2049271808 hasConceptScore W2049271808C86803240 @default.
- W2049271808 hasIssue "4" @default.
- W2049271808 hasLocation W20492718081 @default.
- W2049271808 hasLocation W20492718082 @default.
- W2049271808 hasOpenAccess W2049271808 @default.
- W2049271808 hasPrimaryLocation W20492718081 @default.
- W2049271808 hasRelatedWork W1985504131 @default.
- W2049271808 hasRelatedWork W1988256589 @default.
- W2049271808 hasRelatedWork W2001179265 @default.
- W2049271808 hasRelatedWork W2027692137 @default.
- W2049271808 hasRelatedWork W2029713308 @default.
- W2049271808 hasRelatedWork W2087983409 @default.
- W2049271808 hasRelatedWork W2104475498 @default.
- W2049271808 hasRelatedWork W2153425923 @default.
- W2049271808 hasRelatedWork W2417216812 @default.
- W2049271808 hasRelatedWork W2922132368 @default.
- W2049271808 hasVolume "3" @default.
- W2049271808 isParatext "false" @default.
- W2049271808 isRetracted "false" @default.
- W2049271808 magId "2049271808" @default.
- W2049271808 workType "article" @default.