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- W2049275964 abstract "The Notch signalling pathway plays a highly-conserved role in regulating the cellular differentiation and proliferation events that characterise pattern formation in the embryo. As cells in the embryo respond to environmental signals, similarly T-cells in the peripheral immune system must monitor their environment for antigens and respond accordingly by entering one of several potential differentiation pathways. Recent studies have identified a role for the Notch pathway in regulating the responses of T-cells in the periphery. In this review, we discuss these findings in the context of the Notch signalling pathway's role as an orchestrator of cellular differentiation, and propose a central role for Notch as a regulator of immune system function." @default.
- W2049275964 created "2016-06-24" @default.
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- W2049275964 date "2003-04-01" @default.
- W2049275964 modified "2023-10-16" @default.
- W2049275964 title "Notch signalling in the regulation of peripheral T-cell function" @default.
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- W2049275964 doi "https://doi.org/10.1016/s1084-9521(02)00181-7" @default.
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