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• W2049276474 abstract "The first aim is to study the neuroprotective effects of Naoyikang (traditional Chinese medicine) on memory deficits in senescent mice induced by consecutive injection of D-galactose and NaNO2 for 60 days. The second aim is to study the neuroprotective effects of Naoyikang on injury in primary cultured hippocampus neurons induced by D-galactose. Part1:Oral administration of Naoyikang(2.4,7.2,24g·kg–1·d–1) started from 1st day of the experiment. Electrical maze test and water maze test were used to evaluate the learning and memory function of mice. The activity of MAO-B and SOD and GSH-px and Na+-K+-ATP enzyme and Ca2+– ATP enzyme and the contents of MDA and NO in the cerebral cortex and hippocampus were assayed by different biochemical methods. The expression of Bax, Bcl-2 and Bcl-xl mRNA was detected by RT-PCR. Part 2: In primary rat neuron culture, D- galactose and Naoyikang-containing sera were added into the medium. The neural survival rate was calculated with MTT. The biochemical markers mentioned above were assayed by biochemical methods. The expression of Bax and Bcl-2 and Bcl-xl mRNA was detected with RT-PCR. Part1:The results indicated that combined injection of D-galactose and NaNO2 induced memory impairment of mice. In addition, SOD and GSH-px and ATP enzyme activities decreased while MDA level and MAO-B activity increased in mouse brain. Administration of Naoyikang significantly improved the cognitive deficits and the biochemical markers mentioned above and regulated the expression of Bax and Bcl-2 and Bcl-xl mRNA in mouse brain. Part 2: The results indicated that the neural survival rate in injured neurons was lowered. Administration of Naoyikang significantly improved the neural survival rate and the biochemical markers mentioned above and decreased the expression of Bax-mRNA and increased the expression of Bcl-2 and Bcl-xl mRNA in injured neurons. These results suggest that Naoyikang is worth testing for further preclinical study aimed for senescence and dementia." @default.
• W2049276474 created "2016-06-24" @default.
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• W2049276474 date "2008-07-01" @default.
• W2049276474 modified "2023-09-27" @default.
• W2049276474 title "P2-476: Effects and mechanisms of naoyikang on the model of Alzheimer's disease" @default.
• W2049276474 doi "https://doi.org/10.1016/j.jalz.2008.05.1554" @default.
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