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• W2049277771 endingPage "13" @default.
• W2049277771 startingPage "1" @default.
• W2049277771 abstract "Signal transduction pathways use protein kinases for the modification of protein function by phosphorylation. A major question in the field is how protein kinases achieve the specificity required to regulate multiple cellular functions. Here we review recent studies that illuminate the mechanisms used by three families of Ser/Thr protein kinases to achieve substrate specificity. These kinases rely on direct docking interactions with substrates, using sites distinct from the phospho-acceptor sequences. Docking interactions also contribute to the specificity and regulation of protein kinase activities. Mitogen-activated protein kinase (MAPK) family members can associate with and phosphorylate specific substrates by virtue of minor variations in their docking sequences. Interestingly, the same MAPK docking pocket that binds substrates also binds docking sequences of positive and negative MAPK regulators. In the case of glycogen synthase kinase 3 (GSK3), the presence of a phosphate-binding site allows docking of previously phosphorylated (primed) substrates; this docking site is also required for the mechanism of GSK3 inhibition by phosphorylation. In contrast, non-primed substrates interact with a different region of GSK3. Phosphoinositide-dependent protein kinase-1 (PDK1) contains a hydrophobic pocket that interacts with a hydrophobic motif present in all known substrates, enabling their efficient phosphorylation. Binding of the substrate hydrophobic motifs to the pocket in the kinase domain activates PDK1 and other members of the AGC family of protein kinases. Finally, the analysis of protein kinase structures indicates that the sites used for docking substrates can also bind N- and C-terminal extensions to the kinase catalytic core and participate in the regulation of its activity." @default.
• W2049277771 created "2016-06-24" @default.
• W2049277771 creator A5007413056 @default.
• W2049277771 creator A5064241770 @default.
• W2049277771 date "2003-05-15" @default.
• W2049277771 modified "2023-10-17" @default.
• W2049277771 title "Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions" @default.
• W2049277771 cites W1011007954 @default.
• W2049277771 cites W1489736060 @default.
• W2049277771 cites W1495346616 @default.
• W2049277771 cites W1507401672 @default.
• W2049277771 cites W1531537331 @default.
• W2049277771 cites W1544046482 @default.
• W2049277771 cites W1591640849 @default.
• W2049277771 cites W1600771042 @default.
• W2049277771 cites W1833591189 @default.
• W2049277771 cites W1857109061 @default.
• W2049277771 cites W1905797098 @default.
• W2049277771 cites W1964631519 @default.
• W2049277771 cites W1964887620 @default.
• W2049277771 cites W1967550038 @default.
• W2049277771 cites W1968189883 @default.
• W2049277771 cites W1968534178 @default.
• W2049277771 cites W1969939692 @default.
• W2049277771 cites W1972145919 @default.
• W2049277771 cites W1973473002 @default.
• W2049277771 cites W1973837499 @default.
• W2049277771 cites W1974241409 @default.
• W2049277771 cites W1979111516 @default.
• W2049277771 cites W1980028299 @default.
• W2049277771 cites W1980514336 @default.
• W2049277771 cites W1982958012 @default.
• W2049277771 cites W1985065252 @default.
• W2049277771 cites W1990164081 @default.
• W2049277771 cites W1992023215 @default.
• W2049277771 cites W1992945955 @default.
• W2049277771 cites W1994268275 @default.
• W2049277771 cites W1994351845 @default.
• W2049277771 cites W1994762541 @default.
• W2049277771 cites W1994954884 @default.
• W2049277771 cites W1996086031 @default.
• W2049277771 cites W1998261085 @default.
• W2049277771 cites W1998275863 @default.
• W2049277771 cites W1999377902 @default.
• W2049277771 cites W2001959826 @default.
• W2049277771 cites W2004926623 @default.
• W2049277771 cites W2005063238 @default.
• W2049277771 cites W2007444505 @default.
• W2049277771 cites W2008669399 @default.
• W2049277771 cites W2010422684 @default.
• W2049277771 cites W2012868552 @default.
• W2049277771 cites W2014792240 @default.
• W2049277771 cites W2017012572 @default.
• W2049277771 cites W2017394099 @default.
• W2049277771 cites W2017592134 @default.
• W2049277771 cites W2018221682 @default.
• W2049277771 cites W2018380860 @default.
• W2049277771 cites W2022309233 @default.
• W2049277771 cites W2023934239 @default.
• W2049277771 cites W2027649846 @default.
• W2049277771 cites W2028970288 @default.
• W2049277771 cites W2030205108 @default.
• W2049277771 cites W2030349770 @default.
• W2049277771 cites W2030720692 @default.
• W2049277771 cites W2031889181 @default.
• W2049277771 cites W2032666422 @default.
• W2049277771 cites W2038982119 @default.
• W2049277771 cites W2039193709 @default.
• W2049277771 cites W2041798139 @default.
• W2049277771 cites W2047604907 @default.
• W2049277771 cites W2047623534 @default.
• W2049277771 cites W2052071148 @default.
• W2049277771 cites W2052316866 @default.
• W2049277771 cites W2057069307 @default.
• W2049277771 cites W2058012673 @default.
• W2049277771 cites W2058138221 @default.
• W2049277771 cites W2059034341 @default.
• W2049277771 cites W2059986458 @default.
• W2049277771 cites W2061170173 @default.
• W2049277771 cites W2061699263 @default.
• W2049277771 cites W2065477683 @default.
• W2049277771 cites W2066469176 @default.
• W2049277771 cites W2067371805 @default.
• W2049277771 cites W2067405360 @default.
• W2049277771 cites W2067832283 @default.
• W2049277771 cites W2069602875 @default.
• W2049277771 cites W2070580124 @default.
• W2049277771 cites W2073158293 @default.
• W2049277771 cites W2075319861 @default.
• W2049277771 cites W2078747147 @default.
• W2049277771 cites W2079162518 @default.
• W2049277771 cites W2079557731 @default.
• W2049277771 cites W2082770517 @default.
• W2049277771 cites W2082820955 @default.
• W2049277771 cites W2083076387 @default.
• W2049277771 cites W2083117403 @default.
• W2049277771 cites W2084258581 @default.
• W2049277771 cites W2084766033 @default.

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