FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049278083> ?p ?o ?g. }

• W2049278083 endingPage "5" @default.
• W2049278083 startingPage "1" @default.
• W2049278083 abstract "Members of the Hedgehog (Hh) family of proteins are conserved morphogens that modulate cell fates in target tissues in different developmental systems. Dysregulation of Hh signaling results in a wide range of human diseases. The mature Hh is modified by lipids in two places, with palmitate at the N-terminus and cholesterol at the C-terminus. The lipid modifications are essential to the proper secretion and spreading of the morphogen throughout the extracellular matrix, interacting with heparan sulfate proteoglycans. However, the role of lipid modifications in regulating the range and activity of Hh proteins remains controversial. Here, we aim to resolve this issue by providing a model that is consistent with current and past reports. We propose that the cholesterol moiety functions to restrict the dilution and deregulated spread of the morphogen in the extracellular space. Members of the Hedgehog (Hh) family of proteins are conserved morphogens that modulate cell fates in target tissues in different developmental systems. Dysregulation of Hh signaling results in a wide range of human diseases. The mature Hh is modified by lipids in two places, with palmitate at the N-terminus and cholesterol at the C-terminus. The lipid modifications are essential to the proper secretion and spreading of the morphogen throughout the extracellular matrix, interacting with heparan sulfate proteoglycans. However, the role of lipid modifications in regulating the range and activity of Hh proteins remains controversial. Here, we aim to resolve this issue by providing a model that is consistent with current and past reports. We propose that the cholesterol moiety functions to restrict the dilution and deregulated spread of the morphogen in the extracellular space." @default.
• W2049278083 created "2016-06-24" @default.
• W2049278083 creator A5001080424 @default.
• W2049278083 creator A5007175039 @default.
• W2049278083 date "2007-01-01" @default.
• W2049278083 modified "2023-10-01" @default.
• W2049278083 title "A conserved mechanism of Hedgehog gradient formation by lipid modifications" @default.
• W2049278083 cites W1616421194 @default.
• W2049278083 cites W1866855833 @default.
• W2049278083 cites W1900580575 @default.
• W2049278083 cites W1974518572 @default.
• W2049278083 cites W1982824007 @default.
• W2049278083 cites W1983921526 @default.
• W2049278083 cites W1988597220 @default.
• W2049278083 cites W1996218285 @default.
• W2049278083 cites W2001553948 @default.
• W2049278083 cites W2003609112 @default.
• W2049278083 cites W2017485209 @default.
• W2049278083 cites W2017848407 @default.
• W2049278083 cites W2018886211 @default.
• W2049278083 cites W2022285707 @default.
• W2049278083 cites W2029042594 @default.
• W2049278083 cites W2030943228 @default.
• W2049278083 cites W2031065774 @default.
• W2049278083 cites W2033940805 @default.
• W2049278083 cites W2037079073 @default.
• W2049278083 cites W2047659079 @default.
• W2049278083 cites W2049425193 @default.
• W2049278083 cites W2057723597 @default.
• W2049278083 cites W2059790042 @default.
• W2049278083 cites W2066479550 @default.
• W2049278083 cites W2075639475 @default.
• W2049278083 cites W2081235375 @default.
• W2049278083 cites W2082074319 @default.
• W2049278083 cites W2085144002 @default.
• W2049278083 cites W2086751240 @default.
• W2049278083 cites W2089749296 @default.
• W2049278083 cites W2101902403 @default.
• W2049278083 cites W2108707301 @default.
• W2049278083 cites W2110643873 @default.
• W2049278083 cites W2118726922 @default.
• W2049278083 cites W2124711584 @default.
• W2049278083 cites W2125611937 @default.
• W2049278083 cites W2142112187 @default.
• W2049278083 cites W2152401277 @default.
• W2049278083 cites W2153188090 @default.
• W2049278083 cites W2156416422 @default.
• W2049278083 cites W2158483162 @default.
• W2049278083 cites W2162892059 @default.
• W2049278083 doi "https://doi.org/10.1016/j.tcb.2006.11.002" @default.
• W2049278083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17126548" @default.
• W2049278083 hasPublicationYear "2007" @default.
• W2049278083 type Work @default.
• W2049278083 sameAs 2049278083 @default.
• W2049278083 citedByCount "73" @default.
• W2049278083 countsByYear W20492780832012 @default.
• W2049278083 countsByYear W20492780832013 @default.
• W2049278083 countsByYear W20492780832014 @default.
• W2049278083 countsByYear W20492780832015 @default.
• W2049278083 countsByYear W20492780832016 @default.
• W2049278083 countsByYear W20492780832017 @default.
• W2049278083 countsByYear W20492780832018 @default.
• W2049278083 countsByYear W20492780832019 @default.
• W2049278083 countsByYear W20492780832020 @default.
• W2049278083 countsByYear W20492780832021 @default.
• W2049278083 countsByYear W20492780832022 @default.
• W2049278083 countsByYear W20492780832023 @default.
• W2049278083 crossrefType "journal-article" @default.
• W2049278083 hasAuthorship W2049278083A5001080424 @default.
• W2049278083 hasAuthorship W2049278083A5007175039 @default.
• W2049278083 hasBestOaLocation W20492780832 @default.
• W2049278083 hasConcept C104317684 @default.
• W2049278083 hasConcept C189165786 @default.
• W2049278083 hasConcept C2778386714 @default.
• W2049278083 hasConcept C2778539099 @default.
• W2049278083 hasConcept C49039625 @default.
• W2049278083 hasConcept C55493867 @default.
• W2049278083 hasConcept C62478195 @default.
• W2049278083 hasConcept C86803240 @default.
• W2049278083 hasConcept C88498014 @default.
• W2049278083 hasConcept C95444343 @default.
• W2049278083 hasConceptScore W2049278083C104317684 @default.
• W2049278083 hasConceptScore W2049278083C189165786 @default.
• W2049278083 hasConceptScore W2049278083C2778386714 @default.
• W2049278083 hasConceptScore W2049278083C2778539099 @default.
• W2049278083 hasConceptScore W2049278083C49039625 @default.
• W2049278083 hasConceptScore W2049278083C55493867 @default.
• W2049278083 hasConceptScore W2049278083C62478195 @default.
• W2049278083 hasConceptScore W2049278083C86803240 @default.
• W2049278083 hasConceptScore W2049278083C88498014 @default.
• W2049278083 hasConceptScore W2049278083C95444343 @default.
• W2049278083 hasIssue "1" @default.
• W2049278083 hasLocation W20492780831 @default.
• W2049278083 hasLocation W20492780832 @default.
• W2049278083 hasLocation W20492780833 @default.
• W2049278083 hasOpenAccess W2049278083 @default.
• W2049278083 hasPrimaryLocation W20492780831 @default.
• W2049278083 hasRelatedWork W2015347723 @default.

• next