Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049278524> ?p ?o ?g. }
- W2049278524 endingPage "4488" @default.
- W2049278524 startingPage "4488" @default.
- W2049278524 abstract "Eleven new complexes of Cu(II) chloride and nitrate with bis(pyrazol-1-yl)propane and bis[2-(pyrazol-1-yl)ethyl]ether ligands were prepared and characterized by spectral and electrochemical methods. X-Ray crystal structure determination of bis[2-(3,5-dimethylpyrazol-1-yl)ethyl]etherdinitratocopper revealed a hepta-coordinated structure with the bis(pyrazole) ligand coordinated in a tridentate NNO-fashion and both of the nitrate ions in a bidentate fashion. Reaction of Cu(II) nitrate complexes with 2,2'-bipyridyl led to the displacement of one of the nitrate ions into the outer sphere and the formation of mixed-ligand complexes. Mixed-ligand bipyridyl Cu(II) complexes demonstrated the highest superoxide dismutase (SOD)-like activity in a chemical superoxide anion-generating system, with IC(50) values in the low micromolar range. Density functional theory calculations showed that introduction of a bipypidyl ligand into the complexes dramatically lowered the lowest unoccupied molecular orbital (LUMO) energy level, which explains the increased SOD-like activity of these complexes compared to non-bipy species. These bipy complexes were also effective scavengers of reactive oxygen species generated by phagocytes (human neutrophils and murine bone marrow leukocytes) ex vivo. Thus, these bipy mixed-ligand complexes represent a promising class of SOD mimetics for future development." @default.
- W2049278524 created "2016-06-24" @default.
- W2049278524 creator A5000509814 @default.
- W2049278524 creator A5006542271 @default.
- W2049278524 creator A5013186412 @default.
- W2049278524 creator A5053846104 @default.
- W2049278524 creator A5076540388 @default.
- W2049278524 creator A5077189123 @default.
- W2049278524 creator A5077633732 @default.
- W2049278524 date "2009-01-01" @default.
- W2049278524 modified "2023-10-06" @default.
- W2049278524 title "Synthesis, characterization and potent superoxide dismutase-like activity of novel bis(pyrazole)–2,2′-bipyridyl mixed ligand copper(ii) complexes" @default.
- W2049278524 cites W1965711642 @default.
- W2049278524 cites W1975345576 @default.
- W2049278524 cites W1975686051 @default.
- W2049278524 cites W1975839119 @default.
- W2049278524 cites W1978090920 @default.
- W2049278524 cites W1982085892 @default.
- W2049278524 cites W1984614201 @default.
- W2049278524 cites W1988218799 @default.
- W2049278524 cites W1993391955 @default.
- W2049278524 cites W1993519424 @default.
- W2049278524 cites W1994714770 @default.
- W2049278524 cites W1997185763 @default.
- W2049278524 cites W1998613997 @default.
- W2049278524 cites W1998722626 @default.
- W2049278524 cites W1999880393 @default.
- W2049278524 cites W2000203074 @default.
- W2049278524 cites W2000924219 @default.
- W2049278524 cites W2009531762 @default.
- W2049278524 cites W2009984821 @default.
- W2049278524 cites W2015878624 @default.
- W2049278524 cites W2016800344 @default.
- W2049278524 cites W2019631957 @default.
- W2049278524 cites W2022946586 @default.
- W2049278524 cites W2023271753 @default.
- W2049278524 cites W2030687437 @default.
- W2049278524 cites W2033729427 @default.
- W2049278524 cites W2042332509 @default.
- W2049278524 cites W2043181466 @default.
- W2049278524 cites W2051209941 @default.
- W2049278524 cites W2052999189 @default.
- W2049278524 cites W2058363175 @default.
- W2049278524 cites W2059669347 @default.
- W2049278524 cites W2064827067 @default.
- W2049278524 cites W2065965579 @default.
- W2049278524 cites W2072840683 @default.
- W2049278524 cites W2072854658 @default.
- W2049278524 cites W2073558713 @default.
- W2049278524 cites W2073914401 @default.
- W2049278524 cites W2078146328 @default.
- W2049278524 cites W2082235753 @default.
- W2049278524 cites W2091475168 @default.
- W2049278524 cites W2092685664 @default.
- W2049278524 cites W2095565789 @default.
- W2049278524 cites W2102538853 @default.
- W2049278524 cites W2103372863 @default.
- W2049278524 cites W2112129353 @default.
- W2049278524 cites W2116671371 @default.
- W2049278524 cites W2131350133 @default.
- W2049278524 cites W2142665146 @default.
- W2049278524 cites W2143981217 @default.
- W2049278524 cites W2147138564 @default.
- W2049278524 cites W2148616203 @default.
- W2049278524 cites W2152059550 @default.
- W2049278524 cites W2241449258 @default.
- W2049278524 cites W2287312989 @default.
- W2049278524 cites W287861225 @default.
- W2049278524 cites W2951807164 @default.
- W2049278524 cites W3136166850 @default.
- W2049278524 cites W36412138 @default.
- W2049278524 doi "https://doi.org/10.1039/b900869a" @default.
- W2049278524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2806191" @default.
- W2049278524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19488447" @default.
- W2049278524 hasPublicationYear "2009" @default.
- W2049278524 type Work @default.
- W2049278524 sameAs 2049278524 @default.
- W2049278524 citedByCount "45" @default.
- W2049278524 countsByYear W20492785242012 @default.
- W2049278524 countsByYear W20492785242013 @default.
- W2049278524 countsByYear W20492785242014 @default.
- W2049278524 countsByYear W20492785242015 @default.
- W2049278524 countsByYear W20492785242016 @default.
- W2049278524 countsByYear W20492785242017 @default.
- W2049278524 countsByYear W20492785242018 @default.
- W2049278524 countsByYear W20492785242019 @default.
- W2049278524 countsByYear W20492785242020 @default.
- W2049278524 countsByYear W20492785242021 @default.
- W2049278524 countsByYear W20492785242022 @default.
- W2049278524 countsByYear W20492785242023 @default.
- W2049278524 crossrefType "journal-article" @default.
- W2049278524 hasAuthorship W2049278524A5000509814 @default.
- W2049278524 hasAuthorship W2049278524A5006542271 @default.
- W2049278524 hasAuthorship W2049278524A5013186412 @default.
- W2049278524 hasAuthorship W2049278524A5053846104 @default.
- W2049278524 hasAuthorship W2049278524A5076540388 @default.
- W2049278524 hasAuthorship W2049278524A5077189123 @default.
- W2049278524 hasAuthorship W2049278524A5077633732 @default.