FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049283003> ?p ?o ?g. }

• W2049283003 endingPage "489" @default.
• W2049283003 startingPage "483" @default.
• W2049283003 abstract "Background Concern about the potential risks associated with hormone replacement therapy (HRT) has left post-menopausal women and healthcare providers searching for safe and effective means for cardiovascular disease (CVD) risk factor reduction. Methods The Woman On the Move through Activity and Nutrition study is a 5-year clinical trial (2002–2006) designed to test whether a lifestyle intervention will reduce measures of subclinical CVD. Participants were randomized at baseline to a health education or lifestyle change group. The impact of lifestyle intervention on CVD risk factors was examined in 240 women who were initially on HRT at baseline and either continued (n = 110) or discontinued (n = 130) by 18 months. Results The lifestyle-change group significantly decreased weight, body mass index, waist circumference (all p<0.0001), total cholesterol (p=0.02), and LDL cholesterol (LDL-C) (p= 0.01), improved fat intake (p<0.0001), and increased leisure physical activity (p=0.005) when compared with the health education group. HRT discontinuation resulted in increased total cholesterol (p=0.04) and LDL-C (p=0.009). CVD risk factor changes were further explored by the HRT group, stratified by randomized group assignment. Within the health education arm, HRT discontinuers averaged over a 22-mg/dL increase in total cholesterol and LDL-C, while HRT continuers averaged less than 4 mg/dL (p=0.004 and 0.002, respectively). No such differences were noted in the lifestyle-change group (p=0.78 and 0.90, respectively). Conclusions Lifestyle modification was effective for CVD risk factor reduction in post-menopausal women. HRT discontinuation resulted in increased total cholesterol and LDL-C, which were successfully attenuated by a lifestyle intervention incorporating weight loss, physical activity, and dietary modification. Concern about the potential risks associated with hormone replacement therapy (HRT) has left post-menopausal women and healthcare providers searching for safe and effective means for cardiovascular disease (CVD) risk factor reduction. The Woman On the Move through Activity and Nutrition study is a 5-year clinical trial (2002–2006) designed to test whether a lifestyle intervention will reduce measures of subclinical CVD. Participants were randomized at baseline to a health education or lifestyle change group. The impact of lifestyle intervention on CVD risk factors was examined in 240 women who were initially on HRT at baseline and either continued (n = 110) or discontinued (n = 130) by 18 months. The lifestyle-change group significantly decreased weight, body mass index, waist circumference (all p<0.0001), total cholesterol (p=0.02), and LDL cholesterol (LDL-C) (p= 0.01), improved fat intake (p<0.0001), and increased leisure physical activity (p=0.005) when compared with the health education group. HRT discontinuation resulted in increased total cholesterol (p=0.04) and LDL-C (p=0.009). CVD risk factor changes were further explored by the HRT group, stratified by randomized group assignment. Within the health education arm, HRT discontinuers averaged over a 22-mg/dL increase in total cholesterol and LDL-C, while HRT continuers averaged less than 4 mg/dL (p=0.004 and 0.002, respectively). No such differences were noted in the lifestyle-change group (p=0.78 and 0.90, respectively). Lifestyle modification was effective for CVD risk factor reduction in post-menopausal women. HRT discontinuation resulted in increased total cholesterol and LDL-C, which were successfully attenuated by a lifestyle intervention incorporating weight loss, physical activity, and dietary modification." @default.
• W2049283003 created "2016-06-24" @default.
• W2049283003 creator A5005102981 @default.
• W2049283003 creator A5013622454 @default.
• W2049283003 creator A5015838513 @default.
• W2049283003 creator A5049136438 @default.
• W2049283003 creator A5050540306 @default.
• W2049283003 creator A5058975643 @default.
• W2049283003 creator A5069121445 @default.
• W2049283003 creator A5087916636 @default.
• W2049283003 date "2007-06-01" @default.
• W2049283003 modified "2023-10-17" @default.
• W2049283003 title "Discontinuing Hormone Replacement TherapyAttenuating the Effect on CVD Risk With Lifestyle Changes" @default.
• W2049283003 cites W1424254474 @default.
• W2049283003 cites W1586699954 @default.
• W2049283003 cites W1593442063 @default.
• W2049283003 cites W1923174901 @default.
• W2049283003 cites W1974580748 @default.
• W2049283003 cites W1983521550 @default.
• W2049283003 cites W1998971678 @default.
• W2049283003 cites W2004395090 @default.
• W2049283003 cites W2008699478 @default.
• W2049283003 cites W2010518325 @default.
• W2049283003 cites W2019208380 @default.
• W2049283003 cites W2026891551 @default.
• W2049283003 cites W2045074426 @default.
• W2049283003 cites W2059618711 @default.
• W2049283003 cites W2061987197 @default.
• W2049283003 cites W2073763404 @default.
• W2049283003 cites W2076581061 @default.
• W2049283003 cites W2083177180 @default.
• W2049283003 cites W2099605448 @default.
• W2049283003 cites W2113264115 @default.
• W2049283003 cites W2113991276 @default.
• W2049283003 cites W2121190446 @default.
• W2049283003 cites W2123609879 @default.
• W2049283003 cites W2132749448 @default.
• W2049283003 cites W2138597449 @default.
• W2049283003 cites W2143015087 @default.
• W2049283003 cites W2146536851 @default.
• W2049283003 cites W2158822657 @default.
• W2049283003 cites W2247997571 @default.
• W2049283003 cites W2332951586 @default.
• W2049283003 cites W4254959959 @default.
• W2049283003 doi "https://doi.org/10.1016/j.amepre.2007.02.019" @default.
• W2049283003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2040271" @default.
• W2049283003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17533063" @default.
• W2049283003 hasPublicationYear "2007" @default.
• W2049283003 type Work @default.
• W2049283003 sameAs 2049283003 @default.
• W2049283003 citedByCount "16" @default.
• W2049283003 countsByYear W20492830032012 @default.
• W2049283003 countsByYear W20492830032013 @default.
• W2049283003 countsByYear W20492830032014 @default.
• W2049283003 countsByYear W20492830032021 @default.
• W2049283003 countsByYear W20492830032023 @default.
• W2049283003 crossrefType "journal-article" @default.
• W2049283003 hasAuthorship W2049283003A5005102981 @default.
• W2049283003 hasAuthorship W2049283003A5013622454 @default.
• W2049283003 hasAuthorship W2049283003A5015838513 @default.
• W2049283003 hasAuthorship W2049283003A5049136438 @default.
• W2049283003 hasAuthorship W2049283003A5050540306 @default.
• W2049283003 hasAuthorship W2049283003A5058975643 @default.
• W2049283003 hasAuthorship W2049283003A5069121445 @default.
• W2049283003 hasAuthorship W2049283003A5087916636 @default.
• W2049283003 hasBestOaLocation W20492830032 @default.
• W2049283003 hasConcept C126322002 @default.
• W2049283003 hasConcept C168563851 @default.
• W2049283003 hasConcept C1862650 @default.
• W2049283003 hasConcept C2776193436 @default.
• W2049283003 hasConcept C2778163477 @default.
• W2049283003 hasConcept C2778715236 @default.
• W2049283003 hasConcept C2779279991 @default.
• W2049283003 hasConcept C2780159708 @default.
• W2049283003 hasConcept C2780221984 @default.
• W2049283003 hasConcept C50440223 @default.
• W2049283003 hasConcept C511355011 @default.
• W2049283003 hasConcept C544821477 @default.
• W2049283003 hasConcept C71924100 @default.
• W2049283003 hasConceptScore W2049283003C126322002 @default.
• W2049283003 hasConceptScore W2049283003C168563851 @default.
• W2049283003 hasConceptScore W2049283003C1862650 @default.
• W2049283003 hasConceptScore W2049283003C2776193436 @default.
• W2049283003 hasConceptScore W2049283003C2778163477 @default.
• W2049283003 hasConceptScore W2049283003C2778715236 @default.
• W2049283003 hasConceptScore W2049283003C2779279991 @default.
• W2049283003 hasConceptScore W2049283003C2780159708 @default.
• W2049283003 hasConceptScore W2049283003C2780221984 @default.
• W2049283003 hasConceptScore W2049283003C50440223 @default.
• W2049283003 hasConceptScore W2049283003C511355011 @default.
• W2049283003 hasConceptScore W2049283003C544821477 @default.
• W2049283003 hasConceptScore W2049283003C71924100 @default.
• W2049283003 hasIssue "6" @default.
• W2049283003 hasLocation W20492830031 @default.
• W2049283003 hasLocation W20492830032 @default.
• W2049283003 hasLocation W20492830033 @default.
• W2049283003 hasLocation W20492830034 @default.
• W2049283003 hasOpenAccess W2049283003 @default.

• next