FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049293484> ?p ?o ?g. }

• W2049293484 endingPage "e21387" @default.
• W2049293484 startingPage "e21387" @default.
• W2049293484 abstract "Pseudomonas aeruginosa (PA) and Burkholderia cepacia complex (Bcc), commonly found in the lungs of cystic fibrosis (CF) patients, often produce cyanide (CN), which inhibits cellular respiration. CN in sputa is a potential biomarker for lung infection by CF pathogens. However, its actual concentration in the infected lungs is unknown.This work reports observation of CN in the lungs of mice infected with cyanogenic PA or Bcc strains using a CN fluorescent chemosensor (4',5'-fluorescein dicarboxaldehyde) with a whole animal imaging system. When the CN chemosensor was injected into the lungs of mice intratracheally infected with either PA or B. cepacia strains embedded in agar beads, CN was detected in the millimolar range (1.8 to 4 mM) in the infected lungs. CN concentration in PA-infected lungs rapidly increased within 24 hours but gradually decreased over the following days, while CN concentration in B. cepacia-infected lungs slowly increased, reaching a maximum at 5 days. CN concentrations correlated with the bacterial loads in the lungs. In vivo efficacy of antimicrobial treatments was tested in live mice by monitoring bacteriogenic CN in the lungs.The in vivo imaging method was also found suitable for minimally invasive testing the efficacy of antibiotic compounds as well as for aiding the understanding of bacterial cyanogenesis in CF lungs." @default.
• W2049293484 created "2016-06-24" @default.
• W2049293484 creator A5008456036 @default.
• W2049293484 creator A5021051777 @default.
• W2049293484 creator A5041693633 @default.
• W2049293484 creator A5043920801 @default.
• W2049293484 creator A5046207199 @default.
• W2049293484 creator A5058382490 @default.
• W2049293484 creator A5070894169 @default.
• W2049293484 creator A5087157024 @default.
• W2049293484 date "2011-07-07" @default.
• W2049293484 modified "2023-09-30" @default.
• W2049293484 title "In Vivo Fluorescence Imaging of Bacteriogenic Cyanide in the Lungs of Live Mice Infected with Cystic Fibrosis Pathogens" @default.
• W2049293484 cites W1948277616 @default.
• W2049293484 cites W1966722398 @default.
• W2049293484 cites W1967658858 @default.
• W2049293484 cites W1974522161 @default.
• W2049293484 cites W1978046264 @default.
• W2049293484 cites W1978059664 @default.
• W2049293484 cites W1985975689 @default.
• W2049293484 cites W1988887549 @default.
• W2049293484 cites W1992838973 @default.
• W2049293484 cites W2003908111 @default.
• W2049293484 cites W2006108996 @default.
• W2049293484 cites W2007891562 @default.
• W2049293484 cites W2014112912 @default.
• W2049293484 cites W2018626703 @default.
• W2049293484 cites W2023456873 @default.
• W2049293484 cites W2030832898 @default.
• W2049293484 cites W2033385287 @default.
• W2049293484 cites W2042105116 @default.
• W2049293484 cites W2061909665 @default.
• W2049293484 cites W2062740949 @default.
• W2049293484 cites W2065729941 @default.
• W2049293484 cites W2067757858 @default.
• W2049293484 cites W2068083251 @default.
• W2049293484 cites W2086758294 @default.
• W2049293484 cites W2091815612 @default.
• W2049293484 cites W2092719748 @default.
• W2049293484 cites W2107347870 @default.
• W2049293484 cites W2108649186 @default.
• W2049293484 cites W2109664848 @default.
• W2049293484 cites W2112639066 @default.
• W2049293484 cites W2126507486 @default.
• W2049293484 cites W2130951311 @default.
• W2049293484 cites W2133425351 @default.
• W2049293484 cites W2136746568 @default.
• W2049293484 cites W2137149853 @default.
• W2049293484 cites W2141327299 @default.
• W2049293484 cites W2149734247 @default.
• W2049293484 cites W2155069031 @default.
• W2049293484 cites W2162427999 @default.
• W2049293484 cites W2175019451 @default.
• W2049293484 cites W38120593 @default.
• W2049293484 cites W4211074500 @default.
• W2049293484 cites W4240940294 @default.
• W2049293484 doi "https://doi.org/10.1371/journal.pone.0021387" @default.
• W2049293484 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3131278" @default.
• W2049293484 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21750709" @default.
• W2049293484 hasPublicationYear "2011" @default.
• W2049293484 type Work @default.
• W2049293484 sameAs 2049293484 @default.
• W2049293484 citedByCount "33" @default.
• W2049293484 countsByYear W20492934842012 @default.
• W2049293484 countsByYear W20492934842013 @default.
• W2049293484 countsByYear W20492934842014 @default.
• W2049293484 countsByYear W20492934842015 @default.
• W2049293484 countsByYear W20492934842016 @default.
• W2049293484 countsByYear W20492934842017 @default.
• W2049293484 countsByYear W20492934842018 @default.
• W2049293484 countsByYear W20492934842019 @default.
• W2049293484 countsByYear W20492934842020 @default.
• W2049293484 countsByYear W20492934842021 @default.
• W2049293484 countsByYear W20492934842022 @default.
• W2049293484 crossrefType "journal-article" @default.
• W2049293484 hasAuthorship W2049293484A5008456036 @default.
• W2049293484 hasAuthorship W2049293484A5021051777 @default.
• W2049293484 hasAuthorship W2049293484A5041693633 @default.
• W2049293484 hasAuthorship W2049293484A5043920801 @default.
• W2049293484 hasAuthorship W2049293484A5046207199 @default.
• W2049293484 hasAuthorship W2049293484A5058382490 @default.
• W2049293484 hasAuthorship W2049293484A5070894169 @default.
• W2049293484 hasAuthorship W2049293484A5087157024 @default.
• W2049293484 hasBestOaLocation W20492934841 @default.
• W2049293484 hasConcept C121332964 @default.
• W2049293484 hasConcept C126322002 @default.
• W2049293484 hasConcept C142724271 @default.
• W2049293484 hasConcept C150903083 @default.
• W2049293484 hasConcept C179104552 @default.
• W2049293484 hasConcept C185592680 @default.
• W2049293484 hasConcept C207001950 @default.
• W2049293484 hasConcept C2776938444 @default.
• W2049293484 hasConcept C2777181619 @default.
• W2049293484 hasConcept C2777637488 @default.
• W2049293484 hasConcept C2777714996 @default.
• W2049293484 hasConcept C2777756538 @default.
• W2049293484 hasConcept C2778015030 @default.
• W2049293484 hasConcept C2778455166 @default.

• next