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- W2049309823 abstract "The active transport of serotonin (5-HT) was studied in two cultured cell lines; FET (a finite fibroblast-like cell line derived from the osteomuscular structures of C3H embryo mice) and EUE (a continuous cell line derived from a human embryonal epithelium). These transport mechanisms are characterized by a high affinity carrier mediated system (km approx 1.3 uM and 1.0 uM respectively; Vmax approx 8 pmol/20 min × 106 cells and 2 pmol/20 min × 106 cells respectively) and temperature dependence. Fluoxetine (Lilly 110140) and Chlorimipramine preferentially block FET but not EUE serotonin uptake. Our results suggest that a serotonin-like transport system is present in unspecialized cultured cells, but it differs kinetically from the neuronal serotonin transport mechanism." @default.
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- W2049309823 date "1982-10-01" @default.
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- W2049309823 title "Studies on a neuronal-like transport system for serotonin in two cell lines" @default.
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- W2049309823 doi "https://doi.org/10.1016/s0031-6989(82)80009-x" @default.
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