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• W2049310411 abstract "Transforming growth factor β (TGF-β) may be a crucial regulator of cardiac remodeling. We investigated the association between the TGF-β gene polymorphisms and left ventricular structure. A total of 658 hypertensive subjects were genotyped for the TGF-β1 T869C and TGF-β3 (rs3917187 and rs4252338) polymorphisms. TGF-β3 rs3917187 AA homozygotes had, while accounting for covariates, greater left ventricular end-systolic (LVESD, P = 0.004) and end-diastolic dimension (LVEDD, P = 0.007) than G allele carriers. Moreover, left ventricular mass index (LVMI) in AA genotype was 123.0 ± 3.1 g/m2 significantly higher than that in AG (114.6 ± 1.6 g/m2) and GG (115.4 ± 2.1 g/m2, P = 0.03) genotypes. In multivariate regression analysis, TGF-β3 rs3917187 genotype as an independent predictor had statistically significant effects on LVESD (β = 0.164, P = 0.002), LVEDD (β = 0.172, P = 0.003) and LVMI (β = 0.136, P = 0.016), respectively. In further analyses, we observed a significant interaction between the rs3917187 and alcohol intake in relation to LVESD (Pint = 0.04) and left ventricular fractional shortening (LVFSH, Pint = 0.012). However, no relationship could be found between left ventricular parameters and the T869C or the rs4252338. The present results demonstrated that the TGF-β3 rs3917187 polymorphism was associated with left ventricular structure, and had an interactive influence with alcohol on LVESD and LVFSH in hypertensive subjects." @default.
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• W2049310411 date "2010-04-01" @default.
• W2049310411 modified "2023-09-26" @default.
• W2049310411 title "The association between transforming growth factor β3 polymorphisms and left ventricular structure in hypertensive subjects" @default.
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• W2049310411 doi "https://doi.org/10.1016/j.cca.2010.01.014" @default.
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