FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049326712> ?p ?o ?g. }

• W2049326712 endingPage "375" @default.
• W2049326712 startingPage "367" @default.
• W2049326712 abstract "Glycyrrhizin, a major active constituent of liquorice root (Glycyrrhiza glabra), has a free radical scavenging property, and its effects were evaluated on an animal model of spinal cord injury (SCI) induced by the application of vascular clips (force of 24 g) to the dura via a four-level T5-T8 laminectomy. Spinal cord injury in mice resulted in severe trauma characterized by edema, tissue damage, and apoptosis (measured by terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling staining, Bax, and Bcl-2 expression). Immunohistochemical examination demonstrated a marked increase in immunoreactivity for nitrotyrosine, iNOS, and poly(adenosine diphosphate-ribose) in the spinal cord tissue. Additionally, we demonstrate that these inflammatory events were associated with the activation of nuclear factor-kappaB. In contrast, the degree of (1) spinal cord inflammation and tissue injury (histological score), (2) nitrotyrosine and poly(adenosine diphosphate [ADP] ribose) formation, (3) iNOS expression, (4) nuclear factor-kappaB activation, and (5) apoptosis (terminal deoxynucleotidyltransferase-mediated dUTP-biotin end labeling, Bax, and Bcl-2) was markedly reduced in spinal cord tissue obtained from mice treated with glycyrrhizin extract (10 mg/kg, i.p., 30 min before and 1 and 6 h after SCI). In a separate set of experiments, we have clearly demonstrated that glycyrrhizin extract treatment significantly ameliorated the recovery of limb function (evaluated by motor recovery score). Taken together, our results clearly demonstrate that treatment with glycyrrhizin extract reduces the development of inflammation and tissue injury events associated with spinal cord trauma." @default.
• W2049326712 created "2016-06-24" @default.
• W2049326712 creator A5007893733 @default.
• W2049326712 creator A5024384127 @default.
• W2049326712 creator A5029433441 @default.
• W2049326712 creator A5039540619 @default.
• W2049326712 creator A5040381615 @default.
• W2049326712 creator A5053839749 @default.
• W2049326712 creator A5074289588 @default.
• W2049326712 creator A5084349553 @default.
• W2049326712 creator A5088072206 @default.
• W2049326712 date "2009-04-01" @default.
• W2049326712 modified "2023-10-18" @default.
• W2049326712 title "GLYCYRRHIZIN REDUCES SECONDARY INFLAMMATORY PROCESS AFTER SPINAL CORD COMPRESSION INJURY IN MICE" @default.
• W2049326712 cites W1527455107 @default.
• W2049326712 cites W1965912922 @default.
• W2049326712 cites W1975162804 @default.
• W2049326712 cites W1982525676 @default.
• W2049326712 cites W1988396798 @default.
• W2049326712 cites W1999533776 @default.
• W2049326712 cites W2001681439 @default.
• W2049326712 cites W2012985982 @default.
• W2049326712 cites W2031799324 @default.
• W2049326712 cites W2040724811 @default.
• W2049326712 cites W2057616724 @default.
• W2049326712 cites W2058977770 @default.
• W2049326712 cites W2065183809 @default.
• W2049326712 cites W2071195821 @default.
• W2049326712 cites W2075246896 @default.
• W2049326712 cites W2076731990 @default.
• W2049326712 cites W2078139208 @default.
• W2049326712 cites W2085680930 @default.
• W2049326712 cites W2086707191 @default.
• W2049326712 cites W2088266736 @default.
• W2049326712 cites W2091012424 @default.
• W2049326712 cites W2092772666 @default.
• W2049326712 cites W2094785458 @default.
• W2049326712 cites W2097884013 @default.
• W2049326712 cites W2105965621 @default.
• W2049326712 cites W2127576952 @default.
• W2049326712 cites W2131856974 @default.
• W2049326712 cites W2170645579 @default.
• W2049326712 doi "https://doi.org/10.1097/shk.0b013e3181833b08" @default.
• W2049326712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18665052" @default.
• W2049326712 hasPublicationYear "2009" @default.
• W2049326712 type Work @default.
• W2049326712 sameAs 2049326712 @default.
• W2049326712 citedByCount "39" @default.
• W2049326712 countsByYear W20493267122012 @default.
• W2049326712 countsByYear W20493267122013 @default.
• W2049326712 countsByYear W20493267122014 @default.
• W2049326712 countsByYear W20493267122015 @default.
• W2049326712 countsByYear W20493267122016 @default.
• W2049326712 countsByYear W20493267122017 @default.
• W2049326712 countsByYear W20493267122018 @default.
• W2049326712 countsByYear W20493267122019 @default.
• W2049326712 countsByYear W20493267122020 @default.
• W2049326712 countsByYear W20493267122021 @default.
• W2049326712 countsByYear W20493267122022 @default.
• W2049326712 countsByYear W20493267122023 @default.
• W2049326712 crossrefType "journal-article" @default.
• W2049326712 hasAuthorship W2049326712A5007893733 @default.
• W2049326712 hasAuthorship W2049326712A5024384127 @default.
• W2049326712 hasAuthorship W2049326712A5029433441 @default.
• W2049326712 hasAuthorship W2049326712A5039540619 @default.
• W2049326712 hasAuthorship W2049326712A5040381615 @default.
• W2049326712 hasAuthorship W2049326712A5053839749 @default.
• W2049326712 hasAuthorship W2049326712A5074289588 @default.
• W2049326712 hasAuthorship W2049326712A5084349553 @default.
• W2049326712 hasAuthorship W2049326712A5088072206 @default.
• W2049326712 hasBestOaLocation W20493267121 @default.
• W2049326712 hasConcept C118552586 @default.
• W2049326712 hasConcept C134018914 @default.
• W2049326712 hasConcept C185592680 @default.
• W2049326712 hasConcept C190283241 @default.
• W2049326712 hasConcept C203014093 @default.
• W2049326712 hasConcept C2776332754 @default.
• W2049326712 hasConcept C2776914184 @default.
• W2049326712 hasConcept C2777622882 @default.
• W2049326712 hasConcept C2778334475 @default.
• W2049326712 hasConcept C2779385521 @default.
• W2049326712 hasConcept C2780775167 @default.
• W2049326712 hasConcept C519581460 @default.
• W2049326712 hasConcept C55493867 @default.
• W2049326712 hasConcept C71924100 @default.
• W2049326712 hasConcept C98274493 @default.
• W2049326712 hasConceptScore W2049326712C118552586 @default.
• W2049326712 hasConceptScore W2049326712C134018914 @default.
• W2049326712 hasConceptScore W2049326712C185592680 @default.
• W2049326712 hasConceptScore W2049326712C190283241 @default.
• W2049326712 hasConceptScore W2049326712C203014093 @default.
• W2049326712 hasConceptScore W2049326712C2776332754 @default.
• W2049326712 hasConceptScore W2049326712C2776914184 @default.
• W2049326712 hasConceptScore W2049326712C2777622882 @default.
• W2049326712 hasConceptScore W2049326712C2778334475 @default.
• W2049326712 hasConceptScore W2049326712C2779385521 @default.
• W2049326712 hasConceptScore W2049326712C2780775167 @default.
• W2049326712 hasConceptScore W2049326712C519581460 @default.

• next