Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049365296> ?p ?o ?g. }
- W2049365296 endingPage "854" @default.
- W2049365296 startingPage "844" @default.
- W2049365296 abstract "Eosinophils possess characteristic specific granules. Their content may be important during host defense but it can also cause damage after release at sites of inflammation. We investigated possible lysosomal characteristics of these granules. Lysosome-associated membrane protein (LAMP)-1 and 2, were detected by Western blot, subcellular fractionation, and immunoelectron microscopy (IEM) and were localized to the membrane of specific granules and in vesicles of the cytoplasm, separate from secretory vesicles. No binding of mannose 6-phosphate receptor to proteins of specific granules could be detected, indicating that they are dephosphorylated and mature. Cellular activation by interleukin-5 caused acidification of specific granules, as detected by pH-dependent probes. The acidification was inhibited by concanamycin A (inhibitor of vacuolar H(+)-ATPase). Activation of eosinophils by serum-treated zymosan (STZ) caused degranulation into STZ-containing phagosomes and incorporation of LAMPs to their membranes. In conclusion, specific granules of eosinophils can be regarded as specialized primary lysosomes, a feature that may be important for their function and integrity." @default.
- W2049365296 created "2016-06-24" @default.
- W2049365296 creator A5001265649 @default.
- W2049365296 creator A5014120235 @default.
- W2049365296 creator A5027634416 @default.
- W2049365296 creator A5053689980 @default.
- W2049365296 creator A5063187405 @default.
- W2049365296 creator A5078188665 @default.
- W2049365296 date "2002-03-01" @default.
- W2049365296 modified "2023-10-18" @default.
- W2049365296 title "Specific Granules of Human Eosinophils Have Lysosomal Characteristics: Presence of Lysosome-Associated Membrane Proteins and Acidification upon Cellular Activation" @default.
- W2049365296 cites W1503257987 @default.
- W2049365296 cites W1525792717 @default.
- W2049365296 cites W1552345492 @default.
- W2049365296 cites W1563799601 @default.
- W2049365296 cites W1577453618 @default.
- W2049365296 cites W1589957195 @default.
- W2049365296 cites W1597610606 @default.
- W2049365296 cites W1645373081 @default.
- W2049365296 cites W1662030037 @default.
- W2049365296 cites W1965247392 @default.
- W2049365296 cites W1968322176 @default.
- W2049365296 cites W1984144097 @default.
- W2049365296 cites W2000607281 @default.
- W2049365296 cites W2019368298 @default.
- W2049365296 cites W2027824013 @default.
- W2049365296 cites W2038762894 @default.
- W2049365296 cites W2041794561 @default.
- W2049365296 cites W2042943663 @default.
- W2049365296 cites W2059210606 @default.
- W2049365296 cites W2060256710 @default.
- W2049365296 cites W2073246440 @default.
- W2049365296 cites W2076201212 @default.
- W2049365296 cites W2089451753 @default.
- W2049365296 cites W2093657553 @default.
- W2049365296 cites W2100837269 @default.
- W2049365296 cites W2101108802 @default.
- W2049365296 cites W2103135201 @default.
- W2049365296 cites W2104557299 @default.
- W2049365296 cites W2115569175 @default.
- W2049365296 cites W2125006413 @default.
- W2049365296 cites W2125111589 @default.
- W2049365296 cites W2128048485 @default.
- W2049365296 cites W2129074717 @default.
- W2049365296 cites W2136815729 @default.
- W2049365296 cites W2140596567 @default.
- W2049365296 cites W2161520715 @default.
- W2049365296 cites W2406459958 @default.
- W2049365296 cites W2411229321 @default.
- W2049365296 cites W2414983659 @default.
- W2049365296 cites W4232695801 @default.
- W2049365296 cites W4249954471 @default.
- W2049365296 cites W4254129135 @default.
- W2049365296 doi "https://doi.org/10.1006/bbrc.2002.6512" @default.
- W2049365296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11866442" @default.
- W2049365296 hasPublicationYear "2002" @default.
- W2049365296 type Work @default.
- W2049365296 sameAs 2049365296 @default.
- W2049365296 citedByCount "22" @default.
- W2049365296 countsByYear W20493652962014 @default.
- W2049365296 countsByYear W20493652962015 @default.
- W2049365296 countsByYear W20493652962016 @default.
- W2049365296 countsByYear W20493652962020 @default.
- W2049365296 countsByYear W20493652962022 @default.
- W2049365296 countsByYear W20493652962023 @default.
- W2049365296 crossrefType "journal-article" @default.
- W2049365296 hasAuthorship W2049365296A5001265649 @default.
- W2049365296 hasAuthorship W2049365296A5014120235 @default.
- W2049365296 hasAuthorship W2049365296A5027634416 @default.
- W2049365296 hasAuthorship W2049365296A5053689980 @default.
- W2049365296 hasAuthorship W2049365296A5063187405 @default.
- W2049365296 hasAuthorship W2049365296A5078188665 @default.
- W2049365296 hasConcept C102747710 @default.
- W2049365296 hasConcept C120694314 @default.
- W2049365296 hasConcept C130316041 @default.
- W2049365296 hasConcept C160448771 @default.
- W2049365296 hasConcept C161478664 @default.
- W2049365296 hasConcept C170493617 @default.
- W2049365296 hasConcept C174106267 @default.
- W2049365296 hasConcept C175969161 @default.
- W2049365296 hasConcept C181199279 @default.
- W2049365296 hasConcept C185592680 @default.
- W2049365296 hasConcept C190283241 @default.
- W2049365296 hasConcept C203014093 @default.
- W2049365296 hasConcept C203522944 @default.
- W2049365296 hasConcept C203565725 @default.
- W2049365296 hasConcept C204232928 @default.
- W2049365296 hasConcept C27239569 @default.
- W2049365296 hasConcept C2776914184 @default.
- W2049365296 hasConcept C2777135640 @default.
- W2049365296 hasConcept C2777722557 @default.
- W2049365296 hasConcept C2780216420 @default.
- W2049365296 hasConcept C2993140218 @default.
- W2049365296 hasConcept C41625074 @default.
- W2049365296 hasConcept C49802076 @default.
- W2049365296 hasConcept C55493867 @default.
- W2049365296 hasConcept C86803240 @default.
- W2049365296 hasConcept C95444343 @default.