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- W2049369825 abstract "SUMMARY The key defect in Type 2 diabetes is islet dysfunction, which includes impaired insulin secretion, augmented glucagon secretion and reduced β-cell mass. The incretin hormone GLP-1 targets this islet dysfunction. GLP-1 is inactivated by DPP-4 and, consequently, DPP-4 inhibition has evolved as an efficient treatment of hyperglycemia in Type 2 diabetes since it increases the concentrations of intact GLP-1. Several DPP-4 inhibitors have been developed and all of them have been shown to be efficient in improving glycemia with a low risk for adverse events. This article reviews basic and clinical studies on one of the DPP-4 inhibitors, vildagliptin. It is a specific inhibitor of DPP-4 and improves glycemia both when used in monotherapy and when used as an add-on to metformin, sulfonylurea, thioazolidinedione or insulin in subjects with Type 2 diabetes. Clinical studies have shown that vildagliptin reduces HbA1c in association with a low risk of adverse events, including hypoglycemia, and no weight gain...." @default.
- W2049369825 created "2016-06-24" @default.
- W2049369825 creator A5027109387 @default.
- W2049369825 date "2012-09-01" @default.
- W2049369825 modified "2023-09-27" @default.
- W2049369825 title "Vildagliptin: a DPP-4 inhibitor for the treatment of Type 2 diabetes" @default.
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- W2049369825 doi "https://doi.org/10.2217/dmt.12.40" @default.
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