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- W2049382020 abstract "The c-fes protooncogene encodes a nonreceptor tyrosine kinase (Fes) implicated in cytokine receptor signal transduction, neutrophil survival, and myeloid differentiation. To determine the role of Fes in embryonic development and hematopoiesis, we engineered a null mutation of the murine c-fes locus. c-fes-/- mice are viable but not born in the expected Mendelian ratios. Live born c-fes-/- mice exhibit lymphoid/myeloid homeostasis defects, compromised innate immunity, and increased Stat activation in response to GM-CSF and IL-6 signaling. Therefore, increased cytokine responsiveness in the absence of Fes leads to abnormal myeloid proliferation and functional defects in the macrophage lineage." @default.
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- W2049382020 date "2000-09-01" @default.
- W2049382020 modified "2023-10-06" @default.
- W2049382020 title "Abnormal Stat Activation, Hematopoietic Homeostasis, and Innate Immunity in c-fes−/− Mice" @default.
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- W2049382020 doi "https://doi.org/10.1016/s1074-7613(00)00039-x" @default.
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