FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049386064> ?p ?o ?g. }

• W2049386064 endingPage "1419" @default.
• W2049386064 startingPage "1410" @default.
• W2049386064 abstract "Our specific aim was to assess within-family relationships of basal fibrinolytic activity and its determinants in hyperlipidemic probands (n = 34) with high lipoprotein (a) [Lp(a)] levels (> 35 mg/dL) and their first-degree relatives (n = 74) and in hyperlipidemic probands (n = 19) with Lp(a) < 35 and their first-degree relatives (n = 23). Probands' plasminogen activator inhibitor activity (PAI-Fx), the major fibrinolysis inhibitor, correlated with first-degree relatives' PAI-Fx in high-Lp(a) kindreds (r = .30, P = .06) and in Lp(a) < 35 kindreds (r = .43, P < or = .05). Probands' tissue plasminogen activator activity (tPA-Fx), the major fibrinolysis activator, was inversely associated with first-degree relatives' PAI-Fx in high-Lp(a) kindreds (r = -.30, P = .06) and in Lp(a) < 35 kindreds (r = -.49, P < or = .025). These correlations [irrespective of probands' Lp(a)] pointed to within-family heritability of the major fibrinolysis inhibitor, PAI-Fx, and the fibrinolysis stimulator, tPA-Fx. There were many other within-family correlations. High-Lp(a) probands' tPA-Fx, the stimulator of fibrinolysis, correlated with first-degree relatives' tPA-Fx (r = .32, P < or = .05). High-Lp(a) probands' plasminogen was inversely correlated with first-degree relatives' alpha 2-antiplasmin, a major fibrinolytic inhibitor (r = -.41, P < or = .01), and with their Lp(a) [r = -.24, P < or = .05]. High-Lp(a) probands' tPA-Fx correlated inversely with first-degree relatives' apolipoprotein (apo) B (r = -.28) and triglyceride ([TG] r = -.41), and positively with their high-density lipoprotein cholesterol ([HDLC] r = .40) and apo A-1 (r = .33; all P < or = .025). High-Lp(a) probands' PAI-Fx correlated positively with first-degree relatives' apo B (r = .34) and TG (r = .47), and inversely with HDLC (r = -.34) and apo A-1 (r = -.30; all P < or = .01). By stepwise regression, the Quetelet index (a measure of relative ponderosity) was independently inversely associated with tPA-Fx (P < or = .05) and positively associated with tPA-Ag and PAI-Fx (P < or = .05). TG was a positive independent determinant of PAI-Fx (P < or = .05), alpha 2-antiplasmin (P < or = .05), and plasminogen (P < or = .05). Lp(a) was a positive, independent determinant of fibrinogen (P < or = .05).(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2049386064 created "2016-06-24" @default.
• W2049386064 creator A5003237055 @default.
• W2049386064 creator A5008162992 @default.
• W2049386064 creator A5019616044 @default.
• W2049386064 creator A5038144819 @default.
• W2049386064 creator A5079058910 @default.
• W2049386064 date "1993-11-01" @default.
• W2049386064 modified "2023-09-28" @default.
• W2049386064 title "Inheritance conjointly contributing to fibrinolysis and hyperlipidemia" @default.
• W2049386064 cites W1639997195 @default.
• W2049386064 cites W1863192077 @default.
• W2049386064 cites W1921375678 @default.
• W2049386064 cites W1946263363 @default.
• W2049386064 cites W1967125883 @default.
• W2049386064 cites W1971532438 @default.
• W2049386064 cites W1975002037 @default.
• W2049386064 cites W1978970831 @default.
• W2049386064 cites W1979331523 @default.
• W2049386064 cites W1981004652 @default.
• W2049386064 cites W1996886562 @default.
• W2049386064 cites W1998239323 @default.
• W2049386064 cites W2006697985 @default.
• W2049386064 cites W2008561310 @default.
• W2049386064 cites W2012098057 @default.
• W2049386064 cites W2015843413 @default.
• W2049386064 cites W2019295985 @default.
• W2049386064 cites W2019849071 @default.
• W2049386064 cites W2021056108 @default.
• W2049386064 cites W2035125534 @default.
• W2049386064 cites W2039831544 @default.
• W2049386064 cites W2084124265 @default.
• W2049386064 cites W2094182610 @default.
• W2049386064 cites W2116284648 @default.
• W2049386064 cites W2116404316 @default.
• W2049386064 cites W2143308743 @default.
• W2049386064 cites W2161201457 @default.
• W2049386064 cites W2168745915 @default.
• W2049386064 cites W2203146091 @default.
• W2049386064 cites W2328128781 @default.
• W2049386064 cites W2407413379 @default.
• W2049386064 cites W2410844905 @default.
• W2049386064 cites W2419095027 @default.
• W2049386064 cites W2440651582 @default.
• W2049386064 cites W265405240 @default.
• W2049386064 cites W3111148255 @default.
• W2049386064 cites W4240249109 @default.
• W2049386064 cites W4254330207 @default.
• W2049386064 cites W81463456 @default.
• W2049386064 doi "https://doi.org/10.1016/0026-0495(93)90191-p" @default.
• W2049386064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8231835" @default.
• W2049386064 hasPublicationYear "1993" @default.
• W2049386064 type Work @default.
• W2049386064 sameAs 2049386064 @default.
• W2049386064 citedByCount "11" @default.
• W2049386064 crossrefType "journal-article" @default.
• W2049386064 hasAuthorship W2049386064A5003237055 @default.
• W2049386064 hasAuthorship W2049386064A5008162992 @default.
• W2049386064 hasAuthorship W2049386064A5019616044 @default.
• W2049386064 hasAuthorship W2049386064A5038144819 @default.
• W2049386064 hasAuthorship W2049386064A5079058910 @default.
• W2049386064 hasConcept C104317684 @default.
• W2049386064 hasConcept C126322002 @default.
• W2049386064 hasConcept C134018914 @default.
• W2049386064 hasConcept C188997412 @default.
• W2049386064 hasConcept C2776104379 @default.
• W2049386064 hasConcept C2776825266 @default.
• W2049386064 hasConcept C2778163477 @default.
• W2049386064 hasConcept C2779679481 @default.
• W2049386064 hasConcept C2779862289 @default.
• W2049386064 hasConcept C2780675426 @default.
• W2049386064 hasConcept C2781179581 @default.
• W2049386064 hasConcept C501734568 @default.
• W2049386064 hasConcept C54355233 @default.
• W2049386064 hasConcept C62746215 @default.
• W2049386064 hasConcept C71924100 @default.
• W2049386064 hasConcept C86803240 @default.
• W2049386064 hasConceptScore W2049386064C104317684 @default.
• W2049386064 hasConceptScore W2049386064C126322002 @default.
• W2049386064 hasConceptScore W2049386064C134018914 @default.
• W2049386064 hasConceptScore W2049386064C188997412 @default.
• W2049386064 hasConceptScore W2049386064C2776104379 @default.
• W2049386064 hasConceptScore W2049386064C2776825266 @default.
• W2049386064 hasConceptScore W2049386064C2778163477 @default.
• W2049386064 hasConceptScore W2049386064C2779679481 @default.
• W2049386064 hasConceptScore W2049386064C2779862289 @default.
• W2049386064 hasConceptScore W2049386064C2780675426 @default.
• W2049386064 hasConceptScore W2049386064C2781179581 @default.
• W2049386064 hasConceptScore W2049386064C501734568 @default.
• W2049386064 hasConceptScore W2049386064C54355233 @default.
• W2049386064 hasConceptScore W2049386064C62746215 @default.
• W2049386064 hasConceptScore W2049386064C71924100 @default.
• W2049386064 hasConceptScore W2049386064C86803240 @default.
• W2049386064 hasIssue "11" @default.
• W2049386064 hasLocation W20493860641 @default.
• W2049386064 hasLocation W20493860642 @default.
• W2049386064 hasOpenAccess W2049386064 @default.
• W2049386064 hasPrimaryLocation W20493860641 @default.

• next