Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049386412> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2049386412 endingPage "376" @default.
- W2049386412 startingPage "369" @default.
- W2049386412 abstract "STAT proteins act as signal transducers and activators of transcription in cells treated with cytokines or growth factors. Here we analyzed the possible cooperation between STAT3 and phosphatidylinositol-3 kinase (PI-3 kinase) and its involvement in antiproliferative signals induced by glucocorticoid hormones. Treatment of melanoma cells with dexamethasone (DEX) resulted in coexpression of STAT3 activation and increase in the PI-3 kinase protein level. Using plasmids-containing JAK2 and STAT3 constructs, we demonstrated that activation of JAK/STAT signaling led to up regulation of PI-3 kinase and enhancement of DEX's ability to increase PI-3 kinase levels in target cells. Prolonged DEX treatment of melanoma cells resulted in constitutive increases in both STAT3 and PI-3 kinase protein levels that were correlated with increased melanoma resistance to antiproliferative hormone action. Similarly, forced expression of both STAT3 and PI-3 kinase in melanoma cells led to enhanced resistance to hormone treatment. Forced expression of PI-3 kinase led to increase in STAT3 activity in a JAK-dependent manner, indicating the existence of a feedback regulatory cascade between the JAK/STAT3 and PI-3 kinase pathways. We suggest that protection of melanoma cells from antiproliferative effects of glucocorticoid hormones may be mediated, at least in part, by the constitutive activation of the STAT3/PI-3 kinase signaling pathway." @default.
- W2049386412 created "2016-06-24" @default.
- W2049386412 creator A5019252843 @default.
- W2049386412 creator A5057577271 @default.
- W2049386412 date "2002-11-01" @default.
- W2049386412 modified "2023-09-26" @default.
- W2049386412 title "Signal transducer and activator of transcription-3 and phosphatidylinositol-3 kinase as coordinate regulators of melanoma cell response to glucocorticoid hormones" @default.
- W2049386412 cites W1639582946 @default.
- W2049386412 cites W2000794723 @default.
- W2049386412 cites W2004123711 @default.
- W2049386412 cites W2011707286 @default.
- W2049386412 cites W2024282024 @default.
- W2049386412 cites W2034383694 @default.
- W2049386412 cites W2042204791 @default.
- W2049386412 cites W2054529141 @default.
- W2049386412 cites W2058554631 @default.
- W2049386412 cites W2060037483 @default.
- W2049386412 cites W2063783803 @default.
- W2049386412 cites W2068133168 @default.
- W2049386412 cites W2083802827 @default.
- W2049386412 cites W2101617873 @default.
- W2049386412 cites W2119057870 @default.
- W2049386412 cites W2136305084 @default.
- W2049386412 cites W2152000177 @default.
- W2049386412 cites W2152931086 @default.
- W2049386412 cites W2163046152 @default.
- W2049386412 cites W2175994433 @default.
- W2049386412 cites W2312555199 @default.
- W2049386412 cites W2316897006 @default.
- W2049386412 cites W4234842415 @default.
- W2049386412 cites W4250902260 @default.
- W2049386412 doi "https://doi.org/10.1016/s0960-0760(02)00223-6" @default.
- W2049386412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12589944" @default.
- W2049386412 hasPublicationYear "2002" @default.
- W2049386412 type Work @default.
- W2049386412 sameAs 2049386412 @default.
- W2049386412 citedByCount "12" @default.
- W2049386412 countsByYear W20493864122012 @default.
- W2049386412 countsByYear W20493864122013 @default.
- W2049386412 countsByYear W20493864122015 @default.
- W2049386412 countsByYear W20493864122020 @default.
- W2049386412 countsByYear W20493864122022 @default.
- W2049386412 crossrefType "journal-article" @default.
- W2049386412 hasAuthorship W2049386412A5019252843 @default.
- W2049386412 hasAuthorship W2049386412A5057577271 @default.
- W2049386412 hasConcept C112392421 @default.
- W2049386412 hasConcept C126322002 @default.
- W2049386412 hasConcept C134018914 @default.
- W2049386412 hasConcept C157333092 @default.
- W2049386412 hasConcept C171958077 @default.
- W2049386412 hasConcept C184235292 @default.
- W2049386412 hasConcept C185592680 @default.
- W2049386412 hasConcept C2778923194 @default.
- W2049386412 hasConcept C2780841215 @default.
- W2049386412 hasConcept C32465701 @default.
- W2049386412 hasConcept C42362537 @default.
- W2049386412 hasConcept C502942594 @default.
- W2049386412 hasConcept C62478195 @default.
- W2049386412 hasConcept C71924100 @default.
- W2049386412 hasConcept C86803240 @default.
- W2049386412 hasConcept C95444343 @default.
- W2049386412 hasConceptScore W2049386412C112392421 @default.
- W2049386412 hasConceptScore W2049386412C126322002 @default.
- W2049386412 hasConceptScore W2049386412C134018914 @default.
- W2049386412 hasConceptScore W2049386412C157333092 @default.
- W2049386412 hasConceptScore W2049386412C171958077 @default.
- W2049386412 hasConceptScore W2049386412C184235292 @default.
- W2049386412 hasConceptScore W2049386412C185592680 @default.
- W2049386412 hasConceptScore W2049386412C2778923194 @default.
- W2049386412 hasConceptScore W2049386412C2780841215 @default.
- W2049386412 hasConceptScore W2049386412C32465701 @default.
- W2049386412 hasConceptScore W2049386412C42362537 @default.
- W2049386412 hasConceptScore W2049386412C502942594 @default.
- W2049386412 hasConceptScore W2049386412C62478195 @default.
- W2049386412 hasConceptScore W2049386412C71924100 @default.
- W2049386412 hasConceptScore W2049386412C86803240 @default.
- W2049386412 hasConceptScore W2049386412C95444343 @default.
- W2049386412 hasIssue "4-5" @default.
- W2049386412 hasLocation W20493864121 @default.
- W2049386412 hasLocation W20493864122 @default.
- W2049386412 hasOpenAccess W2049386412 @default.
- W2049386412 hasPrimaryLocation W20493864121 @default.
- W2049386412 hasRelatedWork W2115533799 @default.
- W2049386412 hasRelatedWork W2154799225 @default.
- W2049386412 hasRelatedWork W2356610366 @default.
- W2049386412 hasRelatedWork W2387113850 @default.
- W2049386412 hasRelatedWork W2387527143 @default.
- W2049386412 hasRelatedWork W2523086436 @default.
- W2049386412 hasRelatedWork W2926512122 @default.
- W2049386412 hasRelatedWork W2972231100 @default.
- W2049386412 hasRelatedWork W3010667516 @default.
- W2049386412 hasRelatedWork W3029641958 @default.
- W2049386412 hasVolume "82" @default.
- W2049386412 isParatext "false" @default.
- W2049386412 isRetracted "false" @default.
- W2049386412 magId "2049386412" @default.
- W2049386412 workType "article" @default.