Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049389913> ?p ?o ?g. }
- W2049389913 endingPage "1203" @default.
- W2049389913 startingPage "1188" @default.
- W2049389913 abstract "Despite the modest improvements in patient survival from colorectal cancer in the last few decades, the overall five-year survival rate remains at 40 to 45 percent. Surgical resection is the mainstay of treatment for colorectal cancer; however, nearly one-half of all patients who undergo a potentially curative resection will relapse because of undetected micrometastasis. The fact that the overall survival rate remains poor strongly suggests that the dissemination of these cells occurs early in the disease process and emphasizes the need for finding feasible diagnostic methods with sufficient sensitivity and specificity. The most commonly used technique for the detection of nucleic acid material of disseminated tumor cells is the polymerase chain reaction. We critically review the literature on DNA and messenger ribonucleic acid molecular markers that have been used for the detection of circulating tumor cells in the peripheral blood of patients with colorectal cancer and other solid tumors as appropriate for comparison. The cytokeratins, particularly cytokeratin 19 and cytokeratin 20, are the most investigated prognostic markers, but even for these questions remain about their clinical value, and hence most recent studies are utilizing a combination of factors. There is an urgent need for standardized isolation and analysis techniques to be adopted thus allowing large-scale, appropriately controlled, multicenter trials to be undertaken on the most promising candidate markers." @default.
- W2049389913 created "2016-06-24" @default.
- W2049389913 creator A5000089064 @default.
- W2049389913 creator A5001534061 @default.
- W2049389913 creator A5017413865 @default.
- W2049389913 date "2007-08-01" @default.
- W2049389913 modified "2023-10-17" @default.
- W2049389913 title "Epithelial Molecular Markers in the Peripheral Blood of Patients with Colorectal Cancer" @default.
- W2049389913 cites W1253046850 @default.
- W2049389913 cites W1574332929 @default.
- W2049389913 cites W1596261235 @default.
- W2049389913 cites W1748734394 @default.
- W2049389913 cites W1757535722 @default.
- W2049389913 cites W1765255767 @default.
- W2049389913 cites W1841872817 @default.
- W2049389913 cites W1864823043 @default.
- W2049389913 cites W1886063157 @default.
- W2049389913 cites W1900325538 @default.
- W2049389913 cites W1908195810 @default.
- W2049389913 cites W1926637130 @default.
- W2049389913 cites W1944919483 @default.
- W2049389913 cites W1965330255 @default.
- W2049389913 cites W1965860018 @default.
- W2049389913 cites W1966791779 @default.
- W2049389913 cites W1968208423 @default.
- W2049389913 cites W1968592882 @default.
- W2049389913 cites W1969974964 @default.
- W2049389913 cites W1976010077 @default.
- W2049389913 cites W1977268119 @default.
- W2049389913 cites W1980656099 @default.
- W2049389913 cites W1983230977 @default.
- W2049389913 cites W1984901528 @default.
- W2049389913 cites W1985491008 @default.
- W2049389913 cites W1985858709 @default.
- W2049389913 cites W1987509621 @default.
- W2049389913 cites W1988174955 @default.
- W2049389913 cites W1989000254 @default.
- W2049389913 cites W1989743176 @default.
- W2049389913 cites W1992008029 @default.
- W2049389913 cites W1995200306 @default.
- W2049389913 cites W1997644827 @default.
- W2049389913 cites W2001453669 @default.
- W2049389913 cites W2002043330 @default.
- W2049389913 cites W2013049128 @default.
- W2049389913 cites W2013064069 @default.
- W2049389913 cites W2013276530 @default.
- W2049389913 cites W2014864746 @default.
- W2049389913 cites W2016448471 @default.
- W2049389913 cites W2016787771 @default.
- W2049389913 cites W2017988818 @default.
- W2049389913 cites W2018602849 @default.
- W2049389913 cites W2019295221 @default.
- W2049389913 cites W2020072428 @default.
- W2049389913 cites W2022421041 @default.
- W2049389913 cites W2026586025 @default.
- W2049389913 cites W2026856852 @default.
- W2049389913 cites W2031183472 @default.
- W2049389913 cites W2031705065 @default.
- W2049389913 cites W2034953413 @default.
- W2049389913 cites W2036491039 @default.
- W2049389913 cites W2043587700 @default.
- W2049389913 cites W2043696829 @default.
- W2049389913 cites W2053108509 @default.
- W2049389913 cites W2055130967 @default.
- W2049389913 cites W2055618222 @default.
- W2049389913 cites W2061704447 @default.
- W2049389913 cites W2062583598 @default.
- W2049389913 cites W2063605278 @default.
- W2049389913 cites W2063607526 @default.
- W2049389913 cites W2064047613 @default.
- W2049389913 cites W2070596898 @default.
- W2049389913 cites W2072632288 @default.
- W2049389913 cites W2073469717 @default.
- W2049389913 cites W2078607283 @default.
- W2049389913 cites W2079378073 @default.
- W2049389913 cites W2080816411 @default.
- W2049389913 cites W2083688498 @default.
- W2049389913 cites W2090280322 @default.
- W2049389913 cites W2090424555 @default.
- W2049389913 cites W2095608019 @default.
- W2049389913 cites W2098079931 @default.
- W2049389913 cites W2098771739 @default.
- W2049389913 cites W2101818435 @default.
- W2049389913 cites W2103335542 @default.
- W2049389913 cites W2110727184 @default.
- W2049389913 cites W2112056918 @default.
- W2049389913 cites W2113300169 @default.
- W2049389913 cites W2114724178 @default.
- W2049389913 cites W2115346781 @default.
- W2049389913 cites W2119681138 @default.
- W2049389913 cites W2120426806 @default.
- W2049389913 cites W2124250381 @default.
- W2049389913 cites W2127176937 @default.
- W2049389913 cites W2128857810 @default.
- W2049389913 cites W2131682499 @default.
- W2049389913 cites W2135674966 @default.
- W2049389913 cites W2143384363 @default.
- W2049389913 cites W2146134704 @default.