FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049395204> ?p ?o ?g. }

• W2049395204 endingPage "1473" @default.
• W2049395204 startingPage "1462" @default.
• W2049395204 abstract "Pancreatic secretory trypsin inhibitor (PSTI) is a serine protease inhibitor, expressed in gut mucosa, whose function is unclear. We, therefore, examined the effects of PSTI on gut stability and repair. Transgenic mice overexpressing human PSTI within the jejunum (FABPi(-1178 to +28) hPSTI construct) showed no change in baseline morphology or morphometry but reduced indomethacin-induced injury in overexpressing hPSTI region by 42% (P < 0.01). Systemic recombinant hPSTI did not affect baseline morphology or morphometry but truncated injurious effects in prevention and recovery rat models of dextran-sodium-sulfate-induced colitis. In vitro studies showed PSTI stimulated cell migration but not proliferation of human colonic carcinoma HT29 or immortalized mouse colonic YAMC cells. PSTI also induced changes in vectorial ion transport (short-circuit current) when added to basolateral but not apical surfaces of polarized monolayers of Colony-29 cells. Restitution and vectorial ion transport effects of PSTI were dependent on the presence of a functioning epidermal growth factor (EGF) receptor because cells with a disrupted (EGFR(-/-) immortalized cells) or neutralized (EGFR blocking antibodies or tyrosine kinase inhibitor) receptor prevented these effects. PSTI also reduced the cytokine release of lipopolysaccharide-stimulated dendritic cells. We conclude that administration of PSTI may provide a novel method of stabilizing intestinal mucosa against noxious agents and stimulating repair after injury." @default.
• W2049395204 created "2016-06-24" @default.
• W2049395204 creator A5010402845 @default.
• W2049395204 creator A5017043721 @default.
• W2049395204 creator A5018365102 @default.
• W2049395204 creator A5019785845 @default.
• W2049395204 creator A5022399236 @default.
• W2049395204 creator A5032585100 @default.
• W2049395204 creator A5036042450 @default.
• W2049395204 creator A5060523759 @default.
• W2049395204 creator A5068927209 @default.
• W2049395204 creator A5080061135 @default.
• W2049395204 creator A5088012269 @default.
• W2049395204 date "2007-11-01" @default.
• W2049395204 modified "2023-09-27" @default.
• W2049395204 title "Human Pancreatic Secretory Trypsin Inhibitor Stabilizes Intestinal Mucosa against Noxious Agents" @default.
• W2049395204 cites W1597959509 @default.
• W2049395204 cites W1671459711 @default.
• W2049395204 cites W1965999013 @default.
• W2049395204 cites W1973765441 @default.
• W2049395204 cites W1981190747 @default.
• W2049395204 cites W1985329099 @default.
• W2049395204 cites W1987778106 @default.
• W2049395204 cites W1999223850 @default.
• W2049395204 cites W1999824352 @default.
• W2049395204 cites W2002865239 @default.
• W2049395204 cites W2004542452 @default.
• W2049395204 cites W2017086844 @default.
• W2049395204 cites W2017219336 @default.
• W2049395204 cites W2020259164 @default.
• W2049395204 cites W2032568622 @default.
• W2049395204 cites W2044319171 @default.
• W2049395204 cites W2049834028 @default.
• W2049395204 cites W2067376187 @default.
• W2049395204 cites W2074187916 @default.
• W2049395204 cites W2076519131 @default.
• W2049395204 cites W2083151325 @default.
• W2049395204 cites W2099599782 @default.
• W2049395204 cites W2139916512 @default.
• W2049395204 cites W2151656425 @default.
• W2049395204 cites W2167388218 @default.
• W2049395204 cites W2265378063 @default.
• W2049395204 cites W2404295092 @default.
• W2049395204 cites W243997087 @default.
• W2049395204 cites W2473814699 @default.
• W2049395204 doi "https://doi.org/10.2353/ajpath.2007.070192" @default.
• W2049395204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2043508" @default.
• W2049395204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17982125" @default.
• W2049395204 hasPublicationYear "2007" @default.
• W2049395204 type Work @default.
• W2049395204 sameAs 2049395204 @default.
• W2049395204 citedByCount "12" @default.
• W2049395204 countsByYear W20493952042013 @default.
• W2049395204 countsByYear W20493952042014 @default.
• W2049395204 countsByYear W20493952042015 @default.
• W2049395204 countsByYear W20493952042017 @default.
• W2049395204 countsByYear W20493952042020 @default.
• W2049395204 crossrefType "journal-article" @default.
• W2049395204 hasAuthorship W2049395204A5010402845 @default.
• W2049395204 hasAuthorship W2049395204A5017043721 @default.
• W2049395204 hasAuthorship W2049395204A5018365102 @default.
• W2049395204 hasAuthorship W2049395204A5019785845 @default.
• W2049395204 hasAuthorship W2049395204A5022399236 @default.
• W2049395204 hasAuthorship W2049395204A5032585100 @default.
• W2049395204 hasAuthorship W2049395204A5036042450 @default.
• W2049395204 hasAuthorship W2049395204A5060523759 @default.
• W2049395204 hasAuthorship W2049395204A5068927209 @default.
• W2049395204 hasAuthorship W2049395204A5080061135 @default.
• W2049395204 hasAuthorship W2049395204A5088012269 @default.
• W2049395204 hasBestOaLocation W20493952041 @default.
• W2049395204 hasConcept C126322002 @default.
• W2049395204 hasConcept C128319531 @default.
• W2049395204 hasConcept C134018914 @default.
• W2049395204 hasConcept C153911025 @default.
• W2049395204 hasConcept C185592680 @default.
• W2049395204 hasConcept C203014093 @default.
• W2049395204 hasConcept C2778690821 @default.
• W2049395204 hasConcept C2780397633 @default.
• W2049395204 hasConcept C3019368612 @default.
• W2049395204 hasConcept C502942594 @default.
• W2049395204 hasConcept C552990157 @default.
• W2049395204 hasConcept C55493867 @default.
• W2049395204 hasConcept C71924100 @default.
• W2049395204 hasConcept C86803240 @default.
• W2049395204 hasConceptScore W2049395204C126322002 @default.
• W2049395204 hasConceptScore W2049395204C128319531 @default.
• W2049395204 hasConceptScore W2049395204C134018914 @default.
• W2049395204 hasConceptScore W2049395204C153911025 @default.
• W2049395204 hasConceptScore W2049395204C185592680 @default.
• W2049395204 hasConceptScore W2049395204C203014093 @default.
• W2049395204 hasConceptScore W2049395204C2778690821 @default.
• W2049395204 hasConceptScore W2049395204C2780397633 @default.
• W2049395204 hasConceptScore W2049395204C3019368612 @default.
• W2049395204 hasConceptScore W2049395204C502942594 @default.
• W2049395204 hasConceptScore W2049395204C552990157 @default.
• W2049395204 hasConceptScore W2049395204C55493867 @default.
• W2049395204 hasConceptScore W2049395204C71924100 @default.
• W2049395204 hasConceptScore W2049395204C86803240 @default.

• next