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- W2049403730 abstract "The Escherichia coli lac repressor (R) locates its DNA target site, the operator (O), by a two-step mechanism. In the first step a repressor-DNA (RD) complex is formed at a non-operator site in an ordinary diffusion-controlled reaction. This non-specifically bound repressor then ‘slides’ along the DNA in a one-dimensional diffusion process. A series of intramolecular (within the ‘domain’ of the DNA molecule) dissociation-association steps, interspersed by sliding, eventually results in target location. Similar mechanisms may be used by other genome regulatory proteins in locating specific DNA binding sites." @default.
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- W2049403730 date "1982-02-01" @default.
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- W2049403730 title "How do genome-regulatory proteins locate their DNA target sites?" @default.
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