Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049404486> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2049404486 endingPage "122" @default.
- W2049404486 startingPage "111" @default.
- W2049404486 abstract "We performed a flow cytometric (FCM) analysis of the maturity of reticulocytes using peripheral blood obtained from rats administered 5-fluorouracil (5-FU) at 10, 50 and 100 mg/kg or acethylphenyl hydrazine (APHZ) at 1 and 3 mg/kg to clarify whether the FCM method is useful for assessing toxicity. In the 5-FU-administered rats, a decrease and recovery of the immature reticulocyte fraction (Cell Maturity Index, CMI; Retic Distribution Index, RDI) was observed more rapidly (several days prior to changes in the reticulocyte ratio), and sensitively regarding dose-dependency (clear changes were observed at 10 mg/kg, whereas the reticulocyte ratio was only slightly affected). In addition, there was good agreement between the microscopic results obtained by counting Heilmyer's reticulocyte maturation groups, especially for type I and II, and CMI/RDI assessed by the FCM method after the administration of 50 and 100 mg/kg of 5-FU, the dose at which clear changes were obtained with the microscopic method. In the APHZ-administered rats, a dose-dependent increase in CMI/RDI coinciding with the enhancement of reticulocyte production was observed. The results suggested that the automated FCM method could be a useful and valuable tool to assess and predict impairments of erythropoiesis, especially for CMI and RDI, and could help in the diagnosis of hematological disorders in experimental animals." @default.
- W2049404486 created "2016-06-24" @default.
- W2049404486 creator A5002428778 @default.
- W2049404486 creator A5008396548 @default.
- W2049404486 creator A5013888998 @default.
- W2049404486 creator A5025657816 @default.
- W2049404486 creator A5025906871 @default.
- W2049404486 creator A5035826825 @default.
- W2049404486 date "2006-01-01" @default.
- W2049404486 modified "2023-10-18" @default.
- W2049404486 title "FLOW CYTOMETRIC ANALYSIS OF ERYTHROPOIETIC ABNORMALITY: CHANGES IN THE CELL MATURITY INDEX OF RETICULOCYTES AND RETIC DISTRIBUTION INDEX ARE USEFUL AS INDICATORS OF ERYTHROPOIETIC TOXICITY IN NON-CLINICAL STUDIES" @default.
- W2049404486 cites W1538338564 @default.
- W2049404486 cites W1968887427 @default.
- W2049404486 cites W1969866274 @default.
- W2049404486 cites W1978293455 @default.
- W2049404486 cites W2007956308 @default.
- W2049404486 cites W2016427959 @default.
- W2049404486 cites W2024956397 @default.
- W2049404486 cites W2035657790 @default.
- W2049404486 cites W2067502392 @default.
- W2049404486 cites W2093958228 @default.
- W2049404486 cites W2094499179 @default.
- W2049404486 cites W2324920661 @default.
- W2049404486 cites W2415282149 @default.
- W2049404486 cites W2443247029 @default.
- W2049404486 cites W3023211482 @default.
- W2049404486 cites W3035956048 @default.
- W2049404486 cites W601685533 @default.
- W2049404486 cites W2407845224 @default.
- W2049404486 cites W7888134 @default.
- W2049404486 doi "https://doi.org/10.2131/jts.31.111" @default.
- W2049404486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16772701" @default.
- W2049404486 hasPublicationYear "2006" @default.
- W2049404486 type Work @default.
- W2049404486 sameAs 2049404486 @default.
- W2049404486 citedByCount "6" @default.
- W2049404486 countsByYear W20494044862014 @default.
- W2049404486 crossrefType "journal-article" @default.
- W2049404486 hasAuthorship W2049404486A5002428778 @default.
- W2049404486 hasAuthorship W2049404486A5008396548 @default.
- W2049404486 hasAuthorship W2049404486A5013888998 @default.
- W2049404486 hasAuthorship W2049404486A5025657816 @default.
- W2049404486 hasAuthorship W2049404486A5025906871 @default.
- W2049404486 hasAuthorship W2049404486A5035826825 @default.
- W2049404486 hasBestOaLocation W20494044861 @default.
- W2049404486 hasConcept C104317684 @default.
- W2049404486 hasConcept C105580179 @default.
- W2049404486 hasConcept C110121322 @default.
- W2049404486 hasConcept C126322002 @default.
- W2049404486 hasConcept C134306372 @default.
- W2049404486 hasConcept C16685009 @default.
- W2049404486 hasConcept C203014093 @default.
- W2049404486 hasConcept C2778403015 @default.
- W2049404486 hasConcept C29730261 @default.
- W2049404486 hasConcept C33923547 @default.
- W2049404486 hasConcept C553184892 @default.
- W2049404486 hasConcept C55493867 @default.
- W2049404486 hasConcept C71924100 @default.
- W2049404486 hasConcept C86803240 @default.
- W2049404486 hasConcept C98274493 @default.
- W2049404486 hasConceptScore W2049404486C104317684 @default.
- W2049404486 hasConceptScore W2049404486C105580179 @default.
- W2049404486 hasConceptScore W2049404486C110121322 @default.
- W2049404486 hasConceptScore W2049404486C126322002 @default.
- W2049404486 hasConceptScore W2049404486C134306372 @default.
- W2049404486 hasConceptScore W2049404486C16685009 @default.
- W2049404486 hasConceptScore W2049404486C203014093 @default.
- W2049404486 hasConceptScore W2049404486C2778403015 @default.
- W2049404486 hasConceptScore W2049404486C29730261 @default.
- W2049404486 hasConceptScore W2049404486C33923547 @default.
- W2049404486 hasConceptScore W2049404486C553184892 @default.
- W2049404486 hasConceptScore W2049404486C55493867 @default.
- W2049404486 hasConceptScore W2049404486C71924100 @default.
- W2049404486 hasConceptScore W2049404486C86803240 @default.
- W2049404486 hasConceptScore W2049404486C98274493 @default.
- W2049404486 hasIssue "2" @default.
- W2049404486 hasLocation W20494044861 @default.
- W2049404486 hasLocation W20494044862 @default.
- W2049404486 hasOpenAccess W2049404486 @default.
- W2049404486 hasPrimaryLocation W20494044861 @default.
- W2049404486 hasRelatedWork W2027120561 @default.
- W2049404486 hasRelatedWork W2059210712 @default.
- W2049404486 hasRelatedWork W2137024809 @default.
- W2049404486 hasRelatedWork W2298018290 @default.
- W2049404486 hasRelatedWork W2351155687 @default.
- W2049404486 hasRelatedWork W2360249632 @default.
- W2049404486 hasRelatedWork W2361167606 @default.
- W2049404486 hasRelatedWork W2366071651 @default.
- W2049404486 hasRelatedWork W2392110785 @default.
- W2049404486 hasRelatedWork W4302556551 @default.
- W2049404486 hasVolume "31" @default.
- W2049404486 isParatext "false" @default.
- W2049404486 isRetracted "false" @default.
- W2049404486 magId "2049404486" @default.
- W2049404486 workType "article" @default.