Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049410166> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2049410166 abstract "Process improvements in the synthesis of therapeutic agents and their intermediates are often facilitated by identification of reaction by-products. Analysis by liquid chromatography/mass spectrometry (LC/MS) with electrospray ionization is a powerful approach for obtaining molecular weight information for these compounds. Such analyses are well suited for 'open-access' mass spectrometry using generic chromatographic conditions, provided spectral interpretation for unknown compounds is facile. We have developed a software application (MassAssign) that facilitates automated data processing and molecular weight assignment for chromatographic peaks detected by any standard ultraviolet-visible wavelength detector. The program assigns [M + H](+) ions (and thus molecular weight) in the mass spectra using predetermined criteria. This evaluation process differentiates [M + H](+) ions from other signals in a complex mass spectrum such as those resulting from chromatographic coelution or the presence of multiple species (i.e., fragment ions, singly charged ions, doubly charged ions, adduct ions, proton-bound dimers, etc.). Once the program has evaluated all ions in a mass spectrum that exceed a preset abundance threshold, MassAssign reports either a numeric value-indicating the chromatographic peak consists of a single component having the displayed molecular weight, 'MC'-indicating the peak consisted of multiple components, or 'ND'-that a molecular weight could not be determined unequivocally. The performance of the program was evaluated by comparing mass assignments made by MassAssign against manual interpretation for 55 samples analyzed by positive electrospray ionization using a generic HPLC method. Correct molecular weight assignments were obtained in 90% of the cases." @default.
- W2049410166 created "2016-06-24" @default.
- W2049410166 creator A5017079686 @default.
- W2049410166 creator A5022085311 @default.
- W2049410166 creator A5029951146 @default.
- W2049410166 creator A5040533768 @default.
- W2049410166 creator A5053866938 @default.
- W2049410166 creator A5081005932 @default.
- W2049410166 date "2001-01-01" @default.
- W2049410166 modified "2023-09-27" @default.
- W2049410166 title "Automated molecular weight assignment of electrospray ionization mass spectra" @default.
- W2049410166 cites W1967114014 @default.
- W2049410166 cites W1979641752 @default.
- W2049410166 cites W1984066143 @default.
- W2049410166 cites W2019881759 @default.
- W2049410166 cites W2020574670 @default.
- W2049410166 cites W2021693546 @default.
- W2049410166 cites W2026465178 @default.
- W2049410166 cites W2066122713 @default.
- W2049410166 cites W2074236312 @default.
- W2049410166 cites W2078434837 @default.
- W2049410166 cites W2103718154 @default.
- W2049410166 cites W2142426796 @default.
- W2049410166 cites W2152103647 @default.
- W2049410166 cites W2319969208 @default.
- W2049410166 doi "https://doi.org/10.1002/rcm.519" @default.
- W2049410166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11746916" @default.
- W2049410166 hasPublicationYear "2001" @default.
- W2049410166 type Work @default.
- W2049410166 sameAs 2049410166 @default.
- W2049410166 citedByCount "15" @default.
- W2049410166 countsByYear W20494101662015 @default.
- W2049410166 countsByYear W20494101662018 @default.
- W2049410166 crossrefType "journal-article" @default.
- W2049410166 hasAuthorship W2049410166A5017079686 @default.
- W2049410166 hasAuthorship W2049410166A5022085311 @default.
- W2049410166 hasAuthorship W2049410166A5029951146 @default.
- W2049410166 hasAuthorship W2049410166A5040533768 @default.
- W2049410166 hasAuthorship W2049410166A5053866938 @default.
- W2049410166 hasAuthorship W2049410166A5081005932 @default.
- W2049410166 hasConcept C108204754 @default.
- W2049410166 hasConcept C113196181 @default.
- W2049410166 hasConcept C115139119 @default.
- W2049410166 hasConcept C121332964 @default.
- W2049410166 hasConcept C145148216 @default.
- W2049410166 hasConcept C162356407 @default.
- W2049410166 hasConcept C178790620 @default.
- W2049410166 hasConcept C179998833 @default.
- W2049410166 hasConcept C185592680 @default.
- W2049410166 hasConcept C194451485 @default.
- W2049410166 hasConcept C198291218 @default.
- W2049410166 hasConcept C2776798109 @default.
- W2049410166 hasConcept C40325409 @default.
- W2049410166 hasConcept C40684141 @default.
- W2049410166 hasConcept C43617362 @default.
- W2049410166 hasConcept C62520636 @default.
- W2049410166 hasConceptScore W2049410166C108204754 @default.
- W2049410166 hasConceptScore W2049410166C113196181 @default.
- W2049410166 hasConceptScore W2049410166C115139119 @default.
- W2049410166 hasConceptScore W2049410166C121332964 @default.
- W2049410166 hasConceptScore W2049410166C145148216 @default.
- W2049410166 hasConceptScore W2049410166C162356407 @default.
- W2049410166 hasConceptScore W2049410166C178790620 @default.
- W2049410166 hasConceptScore W2049410166C179998833 @default.
- W2049410166 hasConceptScore W2049410166C185592680 @default.
- W2049410166 hasConceptScore W2049410166C194451485 @default.
- W2049410166 hasConceptScore W2049410166C198291218 @default.
- W2049410166 hasConceptScore W2049410166C2776798109 @default.
- W2049410166 hasConceptScore W2049410166C40325409 @default.
- W2049410166 hasConceptScore W2049410166C40684141 @default.
- W2049410166 hasConceptScore W2049410166C43617362 @default.
- W2049410166 hasConceptScore W2049410166C62520636 @default.
- W2049410166 hasLocation W20494101661 @default.
- W2049410166 hasLocation W20494101662 @default.
- W2049410166 hasOpenAccess W2049410166 @default.
- W2049410166 hasPrimaryLocation W20494101661 @default.
- W2049410166 hasRelatedWork W1514366717 @default.
- W2049410166 hasRelatedWork W1927087288 @default.
- W2049410166 hasRelatedWork W1985718790 @default.
- W2049410166 hasRelatedWork W1994814184 @default.
- W2049410166 hasRelatedWork W2099971061 @default.
- W2049410166 hasRelatedWork W2109378815 @default.
- W2049410166 hasRelatedWork W2136798269 @default.
- W2049410166 hasRelatedWork W2143732158 @default.
- W2049410166 hasRelatedWork W2161087089 @default.
- W2049410166 hasRelatedWork W2164315135 @default.
- W2049410166 hasRelatedWork W2311879968 @default.
- W2049410166 hasRelatedWork W2330835577 @default.
- W2049410166 hasRelatedWork W2997649391 @default.
- W2049410166 hasRelatedWork W3033065047 @default.
- W2049410166 hasRelatedWork W3114622290 @default.
- W2049410166 hasRelatedWork W3145193509 @default.
- W2049410166 hasRelatedWork W3186201441 @default.
- W2049410166 hasRelatedWork W2248134041 @default.
- W2049410166 hasRelatedWork W2598877797 @default.
- W2049410166 hasRelatedWork W2841078448 @default.
- W2049410166 isParatext "false" @default.
- W2049410166 isRetracted "false" @default.
- W2049410166 magId "2049410166" @default.
- W2049410166 workType "article" @default.