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- W2049427149 abstract "We have investigated the role of pairing centers (PCs), cis-acting sites required for accurate segregation of homologous chromosomes during meiosis in C. elegans. We find that these sites play two distinct roles that contribute to proper segregation. Chromosomes lacking PCs usually fail to synapse and also lack a synapsis-independent stabilization activity. The presence of a PC on just one copy of a chromosome pair promotes synapsis but does not support synapsis-independent pairing stabilization, indicating that these functions are separable. Once initiated, synapsis is highly processive, even between nonhomologous chromosomes of disparate lengths, elucidating how translocations suppress meiotic recombination in C. elegans. These findings suggest a multistep pathway for chromosome synapsis in which PCs impart selectivity and efficiency through a kinetic proofreading mechanism. We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability." @default.
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- W2049427149 date "2005-12-01" @default.
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- W2049427149 title "Chromosome Sites Play Dual Roles to Establish Homologous Synapsis during Meiosis in C. elegans" @default.
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- W2049427149 doi "https://doi.org/10.1016/j.cell.2005.09.034" @default.
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