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- W2049433444 abstract "Abstract A selected area of the superior sagittal cortex of 28 rats was examined for changes in synaptic density after chronic exposure to halothane. Rats were exposed to either 50, 100, or 200 ppm halothane from conception to 28 days of age. Synapses were stained with ethanolic phosphotungstic acid and morphometric measurement was carried out with a graphic digitizer. The density of cerebral synapses in rats exposed to halothane was significantly lower than those in control rats. Halothane appeared to reduce synaptic density in a linear dose-dependent effect between 0 and 100 ppm of halothane. This effect appeared to plateau between 100 and 200 ppm halothane. These results have implications in relation to the effects of halothane on the development of synaptic organization and the maturation of synaptic contacts." @default.
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- W2049433444 title "Effects of halothane on cerebral synaptic density" @default.
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- W2049433444 doi "https://doi.org/10.1016/0014-4886(80)90149-1" @default.
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