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• W2049443656 abstract "Abstract Local antibiotic diffusion in rabbit femurs from two new PMMA‐based and nail‐shaped composites, enriched with β‐tricalcium phosphate (P‐TCP) and BaSO 4 or only with BaSO 4 (P‐BaSO 4 ), and soaked in a solution of gentamicin (G) and vancomycin (V) was studied. Nails were implanted into the intramedullary cavity of healthy and osteomyelitic femurs to study the resolution of infection and to quantify the antibiotic penetration into bone by microbiological, pharmacological, and histological tests. A significant progression of osteomyelitis was recorded 7 weeks after MRSA inoculation, whereas no bacteria were found in animals treated with antibiotic‐loaded nails as confirmed by microbiology and histology (Smeltzer score). The release of both antibiotics from composites was high and prompt both in healthy and infected bone; the amount of V was higher than that of G in all bone samples. Antibiotics of both composites were still present in bone 3 weeks after nail implantation. The P‐BaSO4 composite released a lower amount of antibiotics than did P‐TCP. The G–V combination in vivo exerted a synergistic bactericidal effect, which was confirmed by microbiological, histological, and clinical results (no infection). These new porous PMMA composites, soaked in G–V solution in the operating room, might be an effective and useful drug delivery system for osteomyelitis treatment. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:348–355, 2012" @default.
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• W2049443656 date "2011-08-22" @default.
• W2049443656 modified "2023-10-16" @default.
• W2049443656 title "Microbiological and pharmacological tests on new antibiotic‐loaded PMMA‐based composites for the treatment of osteomyelitis" @default.
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• W2049443656 doi "https://doi.org/10.1002/jor.21531" @default.
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