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- W2049447360 abstract "Abstract 1. 1. The effects exerted by various drugs on pyramidal discharges evoked by cortical stimulation were studied in cats and monkeys. 2. 2. Intracarotid injection of acetylcholine caused a brief period of augmentation followed by a prolonged period of depression in pyramidal discharges. Discharges (I waves) depending on cortical interneuronal bombardment of pyramidal cells were the most prominently affected. 3. 3. The effects of acetylcholine were augmented by eserine and blocked by atropine. 4. 4. Injections of eserine, mecholyl, d-tubocurarine, histamine and nicotinic acid, and inhalation of amyl nitrite affected pyramidal discharges in the same way as acetylcholine. 5. 5. It is concluded that the effects of these drugs are attributable to cortical vasodilatation. 6. 6. Because the pyramidal neurons and the cortical interneurons which reactivate them are not directly affected, it is concluded that motor effects induced by cholinergic drugs originate elsewhere." @default.
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- W2049447360 title "Effect of drugs on pyramidal discharges evoked by cortical stimulation" @default.
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- W2049447360 doi "https://doi.org/10.1016/0013-4694(56)90007-4" @default.
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