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• W2049455403 abstract "The present study shows an in vivo role for interleukin-2 in the formation of hepatic granulomatous inflammation in murine Schistosoma japonicum infection. Mice which had been administered an inhibitor to interleukin-2 function during acute infection were noted to have reduced cell-mediated immune responses to ConA and S. japonicum soluble egg antigen (SEA). Lymphoid tissue from these treated mice also have reduced numbers of cells which could be activated by ConA to produce interleukin-2 mRNA as shown by in situ hybridization studies. Mice with less activated lymphocytes had, on the average, a 70% reduction in the granulomatous inflammation surrounding eggs deposited in hepatic tissues of acutely infected mice. The data demonstrate that IL-2 is a key factor in the generation of granulomatous inflammation in S. japonicum infection and suggest that a potential anti-pathology vaccine could be generated based on limiting the presence of IL-2 generated during acute infection." @default.
• W2049455403 created "2016-06-24" @default.
• W2049455403 creator A5014777808 @default.
• W2049455403 date "1991-04-01" @default.
• W2049455403 modified "2023-10-16" @default.
• W2049455403 title "<i>In vivo</i>regulation of<i>S. japonica</i>granuloma formation by an IL-2 antagonist" @default.
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• W2049455403 doi "https://doi.org/10.1017/s0031182000062557" @default.
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