FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049456363> ?p ?o ?g. }

• W2049456363 endingPage "415" @default.
• W2049456363 startingPage "401" @default.
• W2049456363 abstract "DNA repair is essential for cell survival by preventing the formation of mutations which can be lethal and in some cases at the origin of tumours. The DNA repair may occur directly by enzymatic removal of damage from the nucleobase or indirectly, step by step (recognition of the damage, excision, DNA resynthesis). During chemotherapeutic treatment of cancer, the action of DNA repair proteins may lead to tumour cell resistance. This resistance might be overcome by the use of DNA repair inhibitors. The better characterised repair proteins are O6-alkylguanine alkyltransferases (AGT) and poly(ADP-ribose) polymerase (PARP). AGT removes alkylgroups from guanine O6 position via a one step suicide mechanism. The inhibition of AGT activity results from alkylation of the enzyme with a reactive O6modified guanine analogue. Encouraging results were obtained in combination with mono-alkylating agents on cell cultures. O6-benzylguanine (O6-BG) has been used in clinical trials. PARP is implicated in single strand break repair (SSB). This enzyme catalyses the formation of branched (ADP-ribose) polymers using NAD as a unique source of nucleotides. Various compounds including nicotinamide and benzamide analogues appeared to inhibit PARP activity in vitro and in cultured cells. Promising results have been obtained with excision repair pathways: base excision repair (BER) and nucleotide excision repair (NER). Recently, gene therapy has been envisaged to introduce DNA repair protein antagonists or p53 protein to trigger apoptosis." @default.
• W2049456363 created "2016-06-24" @default.
• W2049456363 creator A5026694860 @default.
• W2049456363 creator A5056596331 @default.
• W2049456363 creator A5059471038 @default.
• W2049456363 date "1999-04-01" @default.
• W2049456363 modified "2023-10-11" @default.
• W2049456363 title "DNA repair inhibitors" @default.
• W2049456363 cites W111616551 @default.
• W2049456363 cites W1489512833 @default.
• W2049456363 cites W1845321470 @default.
• W2049456363 cites W1956254450 @default.
• W2049456363 cites W1965892507 @default.
• W2049456363 cites W1968685442 @default.
• W2049456363 cites W1970184435 @default.
• W2049456363 cites W1975853867 @default.
• W2049456363 cites W1979319210 @default.
• W2049456363 cites W2000428852 @default.
• W2049456363 cites W2003448477 @default.
• W2049456363 cites W2004443674 @default.
• W2049456363 cites W2009775180 @default.
• W2049456363 cites W2016767869 @default.
• W2049456363 cites W2025101604 @default.
• W2049456363 cites W2032152522 @default.
• W2049456363 cites W2040840466 @default.
• W2049456363 cites W2042144027 @default.
• W2049456363 cites W2042660284 @default.
• W2049456363 cites W2046343573 @default.
• W2049456363 cites W2056125563 @default.
• W2049456363 cites W2061527580 @default.
• W2049456363 cites W2067756383 @default.
• W2049456363 cites W2074823657 @default.
• W2049456363 cites W2078143818 @default.
• W2049456363 cites W2078307118 @default.
• W2049456363 cites W2078586725 @default.
• W2049456363 cites W2079472423 @default.
• W2049456363 cites W2084793329 @default.
• W2049456363 cites W2085917133 @default.
• W2049456363 cites W2086395211 @default.
• W2049456363 cites W2088920929 @default.
• W2049456363 cites W2096535852 @default.
• W2049456363 cites W2117743516 @default.
• W2049456363 cites W2130983726 @default.
• W2049456363 cites W2131774991 @default.
• W2049456363 cites W2132179503 @default.
• W2049456363 cites W2134175752 @default.
• W2049456363 cites W2134312861 @default.
• W2049456363 cites W2134831636 @default.
• W2049456363 cites W2135956341 @default.
• W2049456363 cites W2140029877 @default.
• W2049456363 cites W2141798197 @default.
• W2049456363 cites W2142224158 @default.
• W2049456363 cites W2149921533 @default.
• W2049456363 cites W2159315273 @default.
• W2049456363 cites W2170564800 @default.
• W2049456363 cites W2172916891 @default.
• W2049456363 cites W2173751778 @default.
• W2049456363 cites W2321041752 @default.
• W2049456363 cites W2414186991 @default.
• W2049456363 doi "https://doi.org/10.1517/13543776.9.4.401" @default.
• W2049456363 hasPublicationYear "1999" @default.
• W2049456363 type Work @default.
• W2049456363 sameAs 2049456363 @default.
• W2049456363 citedByCount "8" @default.
• W2049456363 countsByYear W20494563632015 @default.
• W2049456363 countsByYear W20494563632020 @default.
• W2049456363 countsByYear W20494563632023 @default.
• W2049456363 crossrefType "journal-article" @default.
• W2049456363 hasAuthorship W2049456363A5026694860 @default.
• W2049456363 hasAuthorship W2049456363A5056596331 @default.
• W2049456363 hasAuthorship W2049456363A5059471038 @default.
• W2049456363 hasConcept C104317684 @default.
• W2049456363 hasConcept C104451858 @default.
• W2049456363 hasConcept C134935766 @default.
• W2049456363 hasConcept C143425029 @default.
• W2049456363 hasConcept C145803527 @default.
• W2049456363 hasConcept C153911025 @default.
• W2049456363 hasConcept C182979987 @default.
• W2049456363 hasConcept C185592680 @default.
• W2049456363 hasConcept C187206112 @default.
• W2049456363 hasConcept C192396546 @default.
• W2049456363 hasConcept C2778301229 @default.
• W2049456363 hasConcept C512185932 @default.
• W2049456363 hasConcept C552990157 @default.
• W2049456363 hasConcept C55493867 @default.
• W2049456363 hasConcept C82381507 @default.
• W2049456363 hasConcept C86803240 @default.
• W2049456363 hasConceptScore W2049456363C104317684 @default.
• W2049456363 hasConceptScore W2049456363C104451858 @default.
• W2049456363 hasConceptScore W2049456363C134935766 @default.
• W2049456363 hasConceptScore W2049456363C143425029 @default.
• W2049456363 hasConceptScore W2049456363C145803527 @default.
• W2049456363 hasConceptScore W2049456363C153911025 @default.
• W2049456363 hasConceptScore W2049456363C182979987 @default.
• W2049456363 hasConceptScore W2049456363C185592680 @default.
• W2049456363 hasConceptScore W2049456363C187206112 @default.
• W2049456363 hasConceptScore W2049456363C192396546 @default.
• W2049456363 hasConceptScore W2049456363C2778301229 @default.

• next