FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049460546> ?p ?o ?g. }

• W2049460546 endingPage "25S" @default.
• W2049460546 startingPage "19S" @default.
• W2049460546 abstract "The metabolic fate of doxazosin was investigated in man, mouse, rat and dog using 14C-labelled compound. Bioavailability and pharmacokinetic studies were also conducted with nonlabelled drug, using a specific h.p.l.c. method. Following both oral and intravenous administration, the major route of elimination of drug-related compounds was via the faeces for all species studied. Comparison of the oral and intravenous data show that doxazosin is completely absorbed in man, mouse and rat and is moderately well absorbed in dog. The drug is extensively metabolized, e.g. only about 5% of the dose was excreted unchanged in man. Metabolism in man mainly involves 6- and 7- O-demethylation and 6' and 7'-hydroxylation. These and some minor products were common to the mouse, rat or dog and man. Plasma protein binding was high in all species studied, ranging from 95.3% in the rat to 98.3% in human patients. Oral bioavailability is 60% in dog and approximately 50% in the rat, which is similar to the value of 63% reported for man at therapeutic doses. Mean plasma clearance values were 13 ml min-1 kg-1 (dogs), 30 ml min-1 kg-1 (rats) and 1.2 ml min-1 kg-1 (human subjects). Mean plasma half-life values were 5 h in dogs and 1.2 h in rats: a value of 9 h was reported for human volunteers (cf. 2.5 h for prazosin). The long plasma half-life of doxazosin provides the basis for once-daily dosing." @default.
• W2049460546 created "2016-06-24" @default.
• W2049460546 creator A5002224090 @default.
• W2049460546 creator A5030317179 @default.
• W2049460546 creator A5052343808 @default.
• W2049460546 creator A5063191759 @default.
• W2049460546 creator A5084546086 @default.
• W2049460546 date "1986-02-01" @default.
• W2049460546 modified "2023-09-27" @default.
• W2049460546 title "The metabolism and kinetics of doxazosin in man, mouse, rat and dog." @default.
• W2049460546 cites W1954463628 @default.
• W2049460546 cites W1993658009 @default.
• W2049460546 cites W2019886688 @default.
• W2049460546 cites W2058883847 @default.
• W2049460546 cites W2088479341 @default.
• W2049460546 cites W2093255760 @default.
• W2049460546 cites W2155318267 @default.
• W2049460546 cites W2439282338 @default.
• W2049460546 doi "https://doi.org/10.1111/j.1365-2125.1986.tb02849.x" @default.
• W2049460546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1400758" @default.
• W2049460546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2939865" @default.
• W2049460546 hasPublicationYear "1986" @default.
• W2049460546 type Work @default.
• W2049460546 sameAs 2049460546 @default.
• W2049460546 citedByCount "76" @default.
• W2049460546 countsByYear W20494605462012 @default.
• W2049460546 countsByYear W20494605462013 @default.
• W2049460546 countsByYear W20494605462014 @default.
• W2049460546 countsByYear W20494605462016 @default.
• W2049460546 countsByYear W20494605462018 @default.
• W2049460546 countsByYear W20494605462020 @default.
• W2049460546 countsByYear W20494605462021 @default.
• W2049460546 countsByYear W20494605462022 @default.
• W2049460546 crossrefType "journal-article" @default.
• W2049460546 hasAuthorship W2049460546A5002224090 @default.
• W2049460546 hasAuthorship W2049460546A5030317179 @default.
• W2049460546 hasAuthorship W2049460546A5052343808 @default.
• W2049460546 hasAuthorship W2049460546A5063191759 @default.
• W2049460546 hasAuthorship W2049460546A5084546086 @default.
• W2049460546 hasBestOaLocation W20494605461 @default.
• W2049460546 hasConcept C112705442 @default.
• W2049460546 hasConcept C126322002 @default.
• W2049460546 hasConcept C134018914 @default.
• W2049460546 hasConcept C170493617 @default.
• W2049460546 hasConcept C181199279 @default.
• W2049460546 hasConcept C181389837 @default.
• W2049460546 hasConcept C185592680 @default.
• W2049460546 hasConcept C2776885963 @default.
• W2049460546 hasConcept C2777056448 @default.
• W2049460546 hasConcept C2777590997 @default.
• W2049460546 hasConcept C2780035454 @default.
• W2049460546 hasConcept C2780648677 @default.
• W2049460546 hasConcept C2781109383 @default.
• W2049460546 hasConcept C3941253 @default.
• W2049460546 hasConcept C55493867 @default.
• W2049460546 hasConcept C62231903 @default.
• W2049460546 hasConcept C71924100 @default.
• W2049460546 hasConcept C84393581 @default.
• W2049460546 hasConcept C86803240 @default.
• W2049460546 hasConcept C89311334 @default.
• W2049460546 hasConcept C98274493 @default.
• W2049460546 hasConceptScore W2049460546C112705442 @default.
• W2049460546 hasConceptScore W2049460546C126322002 @default.
• W2049460546 hasConceptScore W2049460546C134018914 @default.
• W2049460546 hasConceptScore W2049460546C170493617 @default.
• W2049460546 hasConceptScore W2049460546C181199279 @default.
• W2049460546 hasConceptScore W2049460546C181389837 @default.
• W2049460546 hasConceptScore W2049460546C185592680 @default.
• W2049460546 hasConceptScore W2049460546C2776885963 @default.
• W2049460546 hasConceptScore W2049460546C2777056448 @default.
• W2049460546 hasConceptScore W2049460546C2777590997 @default.
• W2049460546 hasConceptScore W2049460546C2780035454 @default.
• W2049460546 hasConceptScore W2049460546C2780648677 @default.
• W2049460546 hasConceptScore W2049460546C2781109383 @default.
• W2049460546 hasConceptScore W2049460546C3941253 @default.
• W2049460546 hasConceptScore W2049460546C55493867 @default.
• W2049460546 hasConceptScore W2049460546C62231903 @default.
• W2049460546 hasConceptScore W2049460546C71924100 @default.
• W2049460546 hasConceptScore W2049460546C84393581 @default.
• W2049460546 hasConceptScore W2049460546C86803240 @default.
• W2049460546 hasConceptScore W2049460546C89311334 @default.
• W2049460546 hasConceptScore W2049460546C98274493 @default.
• W2049460546 hasIssue "S1" @default.
• W2049460546 hasLocation W20494605461 @default.
• W2049460546 hasLocation W20494605462 @default.
• W2049460546 hasLocation W20494605463 @default.
• W2049460546 hasLocation W20494605464 @default.
• W2049460546 hasOpenAccess W2049460546 @default.
• W2049460546 hasPrimaryLocation W20494605461 @default.
• W2049460546 hasRelatedWork W1969876219 @default.
• W2049460546 hasRelatedWork W1984498366 @default.
• W2049460546 hasRelatedWork W2025672211 @default.
• W2049460546 hasRelatedWork W2034956313 @default.
• W2049460546 hasRelatedWork W2037803563 @default.
• W2049460546 hasRelatedWork W2070270392 @default.
• W2049460546 hasRelatedWork W2094738707 @default.
• W2049460546 hasRelatedWork W2131557988 @default.
• W2049460546 hasRelatedWork W2160414036 @default.

• next