FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049460839> ?p ?o ?g. }

• W2049460839 endingPage "2906" @default.
• W2049460839 startingPage "2895" @default.
• W2049460839 abstract "The purpose of this investigation was to establish and characterize a cell line derived from a rat choriocarcinoma and to evaluate the usefulness of the cell line as an in vitro model for studying trophoblast cell differentiation. A cell line was generated from choriocarcinoma explants and named Rcho-1. The cell line consisted of a mixture of cell types, including small cells growing in clusters and giant cells possessing very large nuclei. This characteristic morphology was maintained through at least 23 passages and in a series of clonal cell lines isolated from the parent Rcho-1 cell line. The Rcho-1 cell line was capable of expressing placental lactogen-I (PL-I), PL-II, PRL-like protein-A (PLP-A), and PLP-C mRNAs when cultivated in vitro; however, the Rcho-1 cells expressed only PL-I when grown beneath the kidney capsule of host rats. The Rcho- 1 cell line did not express PLP-B under any experimental condition. This pattern of placental PRL expression was maintained for 23 passages. Rcho-1 cells synthesized and secreted PL-I, PL-II, and PLP-A proteins with biochemical characteristics similar to those of their placental counterparts. PL-I and PL-II mRNAs were specifically localized to giant cells. Morphological appearance and placental PRL expression were used as indices for monitoring the differentiation state of Rcho-1 cells grown under various conditions. Both morphological and functional trophoblast cell differentiation were induced by maintaining the Rcho-1 cells in postconfluent culture conditions. Postconfluent Rcho-1 cultures were characterized by an increased percentage of giant cells and an induction of placental PRL expression. Some clonal cell lines derived from the parent Rcho-1 cell line exhibited distinct patterns of differentiation and placental PRL expression. In summary, we have established a rat trophoblast cell line capable of expressing a differentiated phenotype. The differentiated phenotype includes both morphological and functional parameters and can be modulated in vitro. This cell line is a unique model for studying the control of placental PRL gene expression and the regulation of trophoblast cell differentiation. (Endocrinology129: 2895β2906,1991)" @default.
• W2049460839 created "2016-06-24" @default.
• W2049460839 creator A5037806035 @default.
• W2049460839 creator A5075519418 @default.
• W2049460839 date "1991-12-01" @default.
• W2049460839 modified "2023-09-27" @default.
• W2049460839 title "Trophoblast Cell Differentiation: Establishment, Characterization, and Modulation of a Rat Trophoblast Cell Line Expressing Members of the Placental Prolactin Family*" @default.
• W2049460839 cites W1489280661 @default.
• W2049460839 cites W1520211983 @default.
• W2049460839 cites W1530710522 @default.
• W2049460839 cites W1605908081 @default.
• W2049460839 cites W1925949923 @default.
• W2049460839 cites W1970423635 @default.
• W2049460839 cites W1973904974 @default.
• W2049460839 cites W1984352588 @default.
• W2049460839 cites W1999245008 @default.
• W2049460839 cites W2000292621 @default.
• W2049460839 cites W2008273054 @default.
• W2049460839 cites W2011686602 @default.
• W2049460839 cites W2022003306 @default.
• W2049460839 cites W2028408632 @default.
• W2049460839 cites W2043128037 @default.
• W2049460839 cites W2049743615 @default.
• W2049460839 cites W2053814093 @default.
• W2049460839 cites W2063097227 @default.
• W2049460839 cites W2075208587 @default.
• W2049460839 cites W2078119356 @default.
• W2049460839 cites W2080227974 @default.
• W2049460839 cites W2083978151 @default.
• W2049460839 cites W2086689906 @default.
• W2049460839 cites W2089003832 @default.
• W2049460839 cites W2090861225 @default.
• W2049460839 cites W2091967992 @default.
• W2049460839 cites W2092856471 @default.
• W2049460839 cites W2105767263 @default.
• W2049460839 cites W2118134790 @default.
• W2049460839 cites W2128118061 @default.
• W2049460839 cites W2144634347 @default.
• W2049460839 cites W2145986667 @default.
• W2049460839 cites W220967167 @default.
• W2049460839 cites W2273089598 @default.
• W2049460839 cites W2424608326 @default.
• W2049460839 cites W2502567901 @default.
• W2049460839 cites W48964459 @default.
• W2049460839 doi "https://doi.org/10.1210/endo-129-6-2895" @default.
• W2049460839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1954876" @default.
• W2049460839 hasPublicationYear "1991" @default.
• W2049460839 type Work @default.
• W2049460839 sameAs 2049460839 @default.
• W2049460839 citedByCount "196" @default.
• W2049460839 countsByYear W20494608392012 @default.
• W2049460839 countsByYear W20494608392013 @default.
• W2049460839 countsByYear W20494608392014 @default.
• W2049460839 countsByYear W20494608392015 @default.
• W2049460839 countsByYear W20494608392016 @default.
• W2049460839 countsByYear W20494608392017 @default.
• W2049460839 countsByYear W20494608392018 @default.
• W2049460839 countsByYear W20494608392019 @default.
• W2049460839 countsByYear W20494608392021 @default.
• W2049460839 countsByYear W20494608392022 @default.
• W2049460839 crossrefType "journal-article" @default.
• W2049460839 hasAuthorship W2049460839A5037806035 @default.
• W2049460839 hasAuthorship W2049460839A5075519418 @default.
• W2049460839 hasConcept C104317684 @default.
• W2049460839 hasConcept C134018914 @default.
• W2049460839 hasConcept C148738053 @default.
• W2049460839 hasConcept C1491633281 @default.
• W2049460839 hasConcept C153911025 @default.
• W2049460839 hasConcept C172680121 @default.
• W2049460839 hasConcept C189014844 @default.
• W2049460839 hasConcept C202023056 @default.
• W2049460839 hasConcept C202751555 @default.
• W2049460839 hasConcept C2776953305 @default.
• W2049460839 hasConcept C2777064457 @default.
• W2049460839 hasConcept C2777495146 @default.
• W2049460839 hasConcept C2778182776 @default.
• W2049460839 hasConcept C2778489058 @default.
• W2049460839 hasConcept C2779064019 @default.
• W2049460839 hasConcept C2779234561 @default.
• W2049460839 hasConcept C2780059843 @default.
• W2049460839 hasConcept C2780832733 @default.
• W2049460839 hasConcept C54355233 @default.
• W2049460839 hasConcept C55493867 @default.
• W2049460839 hasConcept C62112901 @default.
• W2049460839 hasConcept C71315377 @default.
• W2049460839 hasConcept C81885089 @default.
• W2049460839 hasConcept C86803240 @default.
• W2049460839 hasConcept C95444343 @default.
• W2049460839 hasConceptScore W2049460839C104317684 @default.
• W2049460839 hasConceptScore W2049460839C134018914 @default.
• W2049460839 hasConceptScore W2049460839C148738053 @default.
• W2049460839 hasConceptScore W2049460839C1491633281 @default.
• W2049460839 hasConceptScore W2049460839C153911025 @default.
• W2049460839 hasConceptScore W2049460839C172680121 @default.
• W2049460839 hasConceptScore W2049460839C189014844 @default.
• W2049460839 hasConceptScore W2049460839C202023056 @default.
• W2049460839 hasConceptScore W2049460839C202751555 @default.
• W2049460839 hasConceptScore W2049460839C2776953305 @default.

• next