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• W2049468465 abstract "Prenylcysteine derivatives are of interest for a variety of different biological reasons, including probing the CaaX protein processing pathway. A solid-phase synthesis protocol for the preparation of prenylcysteines using 2-chlorotrityl chloride resin as a solid support has been developed. A series of novel amide-modified farnesylcysteine analogs were synthesized in both high purity and yield under mild conditions. The farnesylcysteine analogs were evaluated using human isoprenylcysteine carboxyl methyltransferase as a biological target, and several new inhibitors, one with significantly enhanced potency, were identified." @default.
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• W2049468465 date "2009-03-25" @default.
• W2049468465 modified "2023-09-27" @default.
• W2049468465 title "Solid-Phase Synthesis of Prenylcysteine Analogs" @default.
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• W2049468465 doi "https://doi.org/10.1021/jo8021692" @default.
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