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- W2049475004 abstract "Ecdysteroid biosynthesis was analyzed in vitro using dissociated Y-organ cells from the shore crab Carcinus maenas. 3-Dehydroecdysone (3DE) was detected as a minor secretory product, in addition to the formerly identified end-products 25-deoxyecdysone and ecdysone (E). In conversion studies, 3DE was formed from tritiated 5β-ketodiol (2,22,25-trideoxyecdysone), 2,22deoxyecdysone and 2-deoxyecdysone but not from E. Further experiments were performed in order to understand the interconversions between 3-oxo and 3β-OH compounds in the crab Y-organ. The enzyme involved in 3β-dehydrogenation was not ecdysone oxidase, a soluble enzyme found in peripheral tissues of many arthropods but it presented strong similarities with 3β-hydroxysteroiddehydrogenase enzymes from vertebrates: it was membrane-bound and NAD+-dependent. Moreover, a NADH-dependent 3β-reduction of several 3-oxo-ecdysteroids was obtained using the same microsomal fraction (100 000×g pellet) of Y-organs, indicating that the reaction might be reversible. As this activity was specific of molting glands, we hypothesize that there is at least one 3β-hydroxysteroid dehydrogenase enzyme involved in the biosynthetic pathway of ecdysteroids." @default.
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- W2049475004 date "1997-04-01" @default.
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- W2049475004 title "Involvement of a 3β-hydroxysteroid dehydrogenase activity in ecdysteroid biosynthesis" @default.
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- W2049475004 doi "https://doi.org/10.1016/s0303-7207(97)04031-8" @default.
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