Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049477809> ?p ?o ?g. }
- W2049477809 endingPage "234" @default.
- W2049477809 startingPage "227" @default.
- W2049477809 abstract "Immunotherapy with high-dose interleukin-2 (IL-2) fails to induce clinical responses in patients with advanced gastrointestinal cancer, but may be effective in patients with malignant melanoma or renal adenocarcinoma. The hypothesis that this failure may be related to immunosuppressive moieties present in patients with advanced gastrointestinal cancer was investigated. Serum samples from 93 patients (32 advanced gastrointestinal cancer, 22 localized gastrointestinal cancer, 13 melanoma/renal adenocarcinoma and 26 age-matched controls) were incubated with peripheral blood lymphocytes from healthy volunteers. The generation of cytolytic lymphokine-activated killer (LAK) cells and the allogeneic mixed lymphocyte response (MLR) were measured in-vitro. LAK effector cytotoxicity (mean % +/- SEM) was significantly (P < 0.05) decreased by serum from advanced gastrointestinal cancer patients (30 +/- 3) compared with that from controls (47 +/- 3), serum from patients with localized gastrointestinal cancer (49 +/- 2) or that from patients with melanoma or renal adenocarcinoma (51 +/- 2). MLR responses were also significantly (P < 0.05) decreased using advanced gastrointestinal cancer patients serum compared to controls. A dose-response phenomenon for suppression of MLR was observed. Serum from patients with melanoma or renal adenocarcinoma was not significantly different to control samples. The immunosuppressive properties of serum from patients with advanced gastrointestinal carcinoma may abrogate therapeutic attempts using IL-2." @default.
- W2049477809 created "2016-06-24" @default.
- W2049477809 creator A5000782452 @default.
- W2049477809 creator A5033082307 @default.
- W2049477809 creator A5055778417 @default.
- W2049477809 date "1993-08-01" @default.
- W2049477809 modified "2023-10-02" @default.
- W2049477809 title "Inhibition of interleukin-2 dependent immune responses by serum from patients with advanced gastrointestinal cancer" @default.
- W2049477809 cites W1500397901 @default.
- W2049477809 cites W1501692141 @default.
- W2049477809 cites W1504877630 @default.
- W2049477809 cites W1865083834 @default.
- W2049477809 cites W1915251617 @default.
- W2049477809 cites W1965150386 @default.
- W2049477809 cites W1965304265 @default.
- W2049477809 cites W1970223922 @default.
- W2049477809 cites W1975568557 @default.
- W2049477809 cites W1976561981 @default.
- W2049477809 cites W1976757484 @default.
- W2049477809 cites W1976907391 @default.
- W2049477809 cites W1979343444 @default.
- W2049477809 cites W1979687401 @default.
- W2049477809 cites W1985981664 @default.
- W2049477809 cites W1996701413 @default.
- W2049477809 cites W2010220709 @default.
- W2049477809 cites W2015643038 @default.
- W2049477809 cites W2028917916 @default.
- W2049477809 cites W2032280843 @default.
- W2049477809 cites W2032512033 @default.
- W2049477809 cites W2036275492 @default.
- W2049477809 cites W2039105268 @default.
- W2049477809 cites W2044068003 @default.
- W2049477809 cites W2047510029 @default.
- W2049477809 cites W2082200724 @default.
- W2049477809 cites W2089828715 @default.
- W2049477809 cites W2104417744 @default.
- W2049477809 cites W2107471563 @default.
- W2049477809 cites W2130537353 @default.
- W2049477809 cites W2133818380 @default.
- W2049477809 cites W2148858488 @default.
- W2049477809 cites W2224120831 @default.
- W2049477809 cites W2322553446 @default.
- W2049477809 cites W2326245275 @default.
- W2049477809 cites W2406505455 @default.
- W2049477809 cites W2409492245 @default.
- W2049477809 cites W2424257540 @default.
- W2049477809 cites W3014857770 @default.
- W2049477809 cites W67410657 @default.
- W2049477809 doi "https://doi.org/10.1016/0960-7404(93)90011-m" @default.
- W2049477809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8252213" @default.
- W2049477809 hasPublicationYear "1993" @default.
- W2049477809 type Work @default.
- W2049477809 sameAs 2049477809 @default.
- W2049477809 citedByCount "1" @default.
- W2049477809 crossrefType "journal-article" @default.
- W2049477809 hasAuthorship W2049477809A5000782452 @default.
- W2049477809 hasAuthorship W2049477809A5033082307 @default.
- W2049477809 hasAuthorship W2049477809A5055778417 @default.
- W2049477809 hasConcept C121608353 @default.
- W2049477809 hasConcept C126322002 @default.
- W2049477809 hasConcept C143998085 @default.
- W2049477809 hasConcept C203014093 @default.
- W2049477809 hasConcept C2777472916 @default.
- W2049477809 hasConcept C2777658100 @default.
- W2049477809 hasConcept C2777701055 @default.
- W2049477809 hasConcept C2777761686 @default.
- W2049477809 hasConcept C2781182431 @default.
- W2049477809 hasConcept C502942594 @default.
- W2049477809 hasConcept C526805850 @default.
- W2049477809 hasConcept C542804219 @default.
- W2049477809 hasConcept C71924100 @default.
- W2049477809 hasConcept C8891405 @default.
- W2049477809 hasConcept C90924648 @default.
- W2049477809 hasConceptScore W2049477809C121608353 @default.
- W2049477809 hasConceptScore W2049477809C126322002 @default.
- W2049477809 hasConceptScore W2049477809C143998085 @default.
- W2049477809 hasConceptScore W2049477809C203014093 @default.
- W2049477809 hasConceptScore W2049477809C2777472916 @default.
- W2049477809 hasConceptScore W2049477809C2777658100 @default.
- W2049477809 hasConceptScore W2049477809C2777701055 @default.
- W2049477809 hasConceptScore W2049477809C2777761686 @default.
- W2049477809 hasConceptScore W2049477809C2781182431 @default.
- W2049477809 hasConceptScore W2049477809C502942594 @default.
- W2049477809 hasConceptScore W2049477809C526805850 @default.
- W2049477809 hasConceptScore W2049477809C542804219 @default.
- W2049477809 hasConceptScore W2049477809C71924100 @default.
- W2049477809 hasConceptScore W2049477809C8891405 @default.
- W2049477809 hasConceptScore W2049477809C90924648 @default.
- W2049477809 hasIssue "4" @default.
- W2049477809 hasLocation W20494778091 @default.
- W2049477809 hasLocation W20494778092 @default.
- W2049477809 hasOpenAccess W2049477809 @default.
- W2049477809 hasPrimaryLocation W20494778091 @default.
- W2049477809 hasRelatedWork W1506984959 @default.
- W2049477809 hasRelatedWork W1996150995 @default.
- W2049477809 hasRelatedWork W2056385328 @default.
- W2049477809 hasRelatedWork W2149871822 @default.
- W2049477809 hasRelatedWork W2155078208 @default.